Search Results - "Francklyn, Christopher S"

Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase by Fang, Pengfei, Yu, Xue, Jeong, Seung Jae, Mirando, Adam, Chen, Kaige, Chen, Xin, Kim, Sunghoon, Francklyn, Christopher S., Guo, Min

“…The polyketide natural product borrelidin displays antibacterial, antifungal, antimalarial, anticancer, insecticidal and herbicidal activities through the…”
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Neuropathy‐associated histidyl‐tRNA synthetase variants attenuate protein synthesis in vitro and disrupt axon outgrowth in developing zebrafish by Mullen, Patrick, Abbott, Jamie A., Wellman, Theresa, Aktar, Mahafuza, Fjeld, Christian, Demeler, Borries, Ebert, Alicia M., Francklyn, Christopher S.

“…Charcot‐Marie‐Tooth disease (CMT) encompasses a set of genetically and clinically heterogeneous neuropathies characterized by length‐dependent dysfunction of…”
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Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis by Williams, Tamara F., Mirando, Adam C., Wilkinson, Barrie, Francklyn, Christopher S., Lounsbury, Karen M.

“…Aminoacyl-tRNA synthetases classically regulate protein synthesis but some also engage in alternative signaling functions related to immune responses and…”
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Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo by Novoa, Eva Maria, Camacho, Noelia, Tor, Anna, Wilkinson, Barrie, Moss, Steven, Marín-García, Patricia, Azcárate, Isabel G., Bautista, José M., Mirando, Adam C., Francklyn, Christopher S., Varon, Sònia, Royo, Miriam, Cortés, Alfred, Ribas de Pouplana, Lluís

“…Significance Malaria remains one of the main health threats in the developing world, with staggering social and economic costs. Resistance to artemisins, the…”
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Regulation of angiogenesis by aminoacyl-tRNA synthetases by Mirando, Adam C, Francklyn, Christopher S, Lounsbury, Karen M

“…In addition to their canonical roles in translation the aminoacyl-tRNA synthetases (ARSs) have developed secondary functions over the course of evolution. Many…”
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Correction: A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases by Waldron, Ashley L, Cahan, Sara Helms, Francklyn, Christopher S, Ebert, Alicia M

“…[This corrects the article DOI: 10.1371/journal.pone.0185317.]…”
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Kinetic Discrimination of tRNA Identity by the Conserved Motif 2 Loop of a Class II Aminoacyl-tRNA Synthetase by Guth, Ethan C., Francklyn, Christopher S.

“…The selection of tRNAs by their cognate aminoacyl-tRNA synthetases is critical for ensuring the fidelity of protein synthesis. While nucleotides that comprise…”
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Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor by Mirando, Adam C., Fang, Pengfei, Williams, Tamara F., Baldor, Linda C., Howe, Alan K., Ebert, Alicia M., Wilkinson, Barrie, Lounsbury, Karen M., Guo, Min, Francklyn, Christopher S.

“…Aminoacyl-tRNA synthetases (AARSs) catalyze an early step in protein synthesis, but also regulate diverse physiological processes in animal cells. These…”
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Asymmetric Amino Acid Activation by Class II Histidyl-tRNA Synthetase from Escherichia coli by Guth, Ethan, Farris, Mindy, Bovee, Michael, Francklyn, Christopher S.

“…Aminoacyl-tRNA synthetases (ARSs) join amino acids to their cognate tRNAs to initiate protein synthesis. Class II ARS possess a unique catalytic domain fold,…”
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Progress and challenges in aminoacyl-tRNA synthetase-based therapeutics by Francklyn, Christopher S., Mullen, Patrick

“…Aminoacyl-tRNA synthetases (ARSs) are universal enzymes that catalyze the attachment of amino acids to the 3′ ends of their cognate tRNAs. The resulting…”
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A Substrate-Assisted Concerted Mechanism for Aminoacylation by a Class II Aminoacyl-tRNA Synthetase by Guth, Ethan, Connolly, Susan H, Bovee, Michael, Francklyn, Christopher S

“…Aminoacyl-tRNA synthetases (aaRS) join amino acids to their cognate transfer RNAs, establishing an essential coding relationship in translation. To investigate…”
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RNA-assisted catalysis in a protein enzyme: The 2'-hydroxyl of tRNAThr A76 promotes aminoacylation by threonyl-tRNA synthetase by Minajigi, Anand, Francklyn, Christopher S

“…Aminoacyl-tRNA synthetases (aaRSs) join amino acids to 1 of 2 terminal hydroxyl groups of their cognate tRNAs, thereby contributing to the overall fidelity of…”
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Substrate Recognition by the Hetero-Octameric ATP Phosphoribosyltransferase from Lactococcus lactis by Champagne, Karen S, Piscitelli, Elise, Francklyn, Christopher S

“…Two families of ATP phosphoribosyl transferases (ATP-PRT) join ATP and 5-phosphoribosyl-1 pyrophosphate (PRPP) in the first reaction of histidine biosynthesis…”
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Aminoacyl Transfer Rate Dictates Choice of Editing Pathway in Threonyl-tRNA Synthetase by Minajigi, Anand, Francklyn, Christopher S.

“…Aminoacyl-tRNA synthetases hydrolyze aminoacyl adenylates and aminoacyl-tRNAs formed from near-cognate amino acids, thereby increasing translational fidelity…”
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Evolutionary conservation of a functionally important backbone phosphate group critical for aminoacylation of histidine tRNAs by Rosen, Abbey E, Brooks, Bonnie S, Guth, Ethan, Francklyn, Christopher S, Musier-Forsyth, Karin

“…All histidine tRNA molecules have an extra nucleotide, G-1, at the 5' end of the acceptor stem. In bacteria, archaea, and eukaryotic organelles, G-1 base pairs…”
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Transfer RNA and human disease by Abbott, Jamie A, Francklyn, Christopher S, Robey-Bond, Susan M

“…Pathological mutations in tRNA genes and tRNA processing enzymes are numerous and result in very complicated clinical phenotypes. Mitochondrial tRNA (mt-tRNA)…”
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A Unique Hydrophobic Cluster Near the Active Site Contributes to Differences in Borrelidin Inhibition among Threonyl-tRNA Synthetases by Ruan, Benfang, Bovee, Michael L., Sacher, Meik, Stathopoulos, Constantinos, Poralla, Karl, Francklyn, Christopher S., Söll, Dieter

“…Borrelidin, a compound with anti-microbial and anti-angiogenic properties, is a known inhibitor of bacterial and eukaryal threonyl-tRNA synthetase (ThrRS). The…”
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DNA Polymerases and Aminoacyl-tRNA Synthetases: Shared Mechanisms for Ensuring the Fidelity of Gene Expression by Francklyn, Christopher S

“…DNA polymerases and aminoacyl-tRNA synthetases (ARSs) represent large enzyme families with critical roles in the transformation of genetic information from DNA…”
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tRNA as an active chemical scaffold for diverse chemical transformations by Francklyn, Christopher S., Minajigi, Anand

“…During protein synthesis, tRNA serves as the intermediary between cognate amino acids and their corresponding RNA trinucleotide codons. Aminoacyl-tRNA is also…”
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Standardizing Analysis of Circulating MicroRNA: Clinical and Biological Relevance by Farina, Nicholas H., Wood, Marie E., Perrapato, Scott D., Francklyn, Christopher S., Stein, Gary S., Stein, Janet L., Lian, Jane B.

“…ABSTRACT Circulating microRNAs (c‐miRNAs) provide a new dimension as clinical biomarkers for disease diagnosis, progression, and response to treatment…”
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