Search Results - "Franck, Helen W.G."

Protein Replacement Therapy and Gene Transfer in Canine Models of Hemophilia A, Hemophilia B, von Willebrand Disease, and Factor VII Deficiency by Nichols, Timothy C, Dillow, Aaron M, Franck, Helen W.G, Merricks, Elizabeth P, Raymer, Robin A, Bellinger, Dwight A, Arruda, Valder R, High, Katherine A

“…Dogs with hemophilia A, hemophilia B, von Willebrand disease (VWD), and factor VII deficiency faithfully recapitulate the severe bleeding phenotype that occurs…”
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Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs by Dumont, Jennifer A., Liu, Tongyao, Low, Susan C., Zhang, Xin, Kamphaus, George, Sakorafas, Paul, Fraley, Cara, Drager, Douglas, Reidy, Thomas, McCue, Justin, Franck, Helen W.G., Merricks, Elizabeth P., Nichols, Timothy C., Bitonti, Alan J., Pierce, Glenn F., Jiang, Haiyan

“…Despite proven benefits, prophylactic treatment for hemophilia A is hampered by the short half-life of factor VIII. A recombinant factor VIII-Fc fusion protein…”
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Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy by Finn, Jonathan D., Ozelo, Margareth C., Sabatino, Denise E., Franck, Helen W.G., Merricks, Elizabeth P., Crudele, Julie M., Zhou, Shangzhen, Kazazian, Haig H., Lillicrap, David, Nichols, Timothy C., Arruda, Valder R.

“…Inhibitory antibodies to factor VIII (FVIII) are a major complication in the treatment of hemophilia A, affecting approximately 20% to 30% of patients. Current…”
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De Novo Synthesis & Storage of Human Factor VIII In Platelets Reduces Bleeding In Canine Hemophilia A by Du, Lily M., Franck, Helen W.G., Merricks, Elizabeth P., Nurden, Paquita, Jensen, Eric S., Haberichter, Sandra L., Hawkins, Troy B., Jacobi, Paula M., Fang, Juan, Nichols, Timothy C., Koukouritaki, Sevasti B., Shi, Qizhen, Montgomery, Robert R., Cornetta, Kenneth, Nurden, Alan T., Wilcox, David A.

“…Abstract 2198 The goal of our study was to develop a clinically relevant strategy for platelet-targeted gene therapy of the inherited bleeding disorder,…”
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