Search Results - "Francisco, Tânia"

Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts by Nordgren, Marcus, Francisco, Tânia, Lismont, Celien, Hennebel, Lore, Brees, Chantal, Wang, Bo, Van Veldhoven, Paul P, Azevedo, Jorge E, Fransen, Marc

“…Peroxisomes are ubiquitous cell organelles essential for human health. To maintain a healthy cellular environment, dysfunctional and superfluous peroxisomes…”
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Methylation defects of imprinted genes in human testicular spermatozoa by Marques, C. Joana, Ph.D, Francisco, Tânia, M.S, Sousa, Sónia, M.S, Carvalho, Filipa, Ph.D, Barros, Alberto, M.D., Ph.D, Sousa, Mário, M.D., Ph.D

“…Objective To study the methylation imprinting marks of two oppositely imprinted genes, H19 and MEST/PEG1 , in human testicular spermatozoa from azoospermic…”
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Membrane topologies of PEX13 and PEX14 provide new insights on the mechanism of protein import into peroxisomes by Barros‐Barbosa, Aurora, Ferreira, Maria J., Rodrigues, Tony A., Pedrosa, Ana G., Grou, Cláudia P., Pinto, Manuel P., Fransen, Marc, Francisco, Tânia, Azevedo, Jorge E.

“…PEX13 and PEX14 are two core components of the so‐called peroxisomal docking/translocation module, the transmembrane hydrophilic channel through which newly…”
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Glutathione and peroxisome redox homeostasis by Ferreira, Maria J., Rodrigues, Tony A., Pedrosa, Ana G., Silva, Ana R., Vilarinho, Beatriz G., Francisco, Tânia, Azevedo, Jorge E.

“…Despite intensive research on peroxisome biochemistry, the role of glutathione in peroxisomal redox homeostasis has remained a matter of speculation for many…”
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Noncanonical and reversible cysteine ubiquitination prevents the overubiquitination of PEX5 at the peroxisomal membrane by Francisco, Tânia, Pedrosa, Ana G, Rodrigues, Tony A, Abalkhail, Tarad, Li, Hongli, Ferreira, Maria J, van der Heden van Noort, Gerbrand J, Fransen, Marc, Hettema, Ewald H, Azevedo, Jorge E

“…PEX5, the peroxisomal protein shuttling receptor, binds newly synthesized proteins in the cytosol and transports them to the organelle. During its stay at the…”
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The intrinsically disordered nature of the peroxisomal protein translocation machinery by Barros‐Barbosa, Aurora, Rodrigues, Tony A., Ferreira, Maria J., Pedrosa, Ana G., Teixeira, Nélson R., Francisco, Tânia, Azevedo, Jorge E.

“…Despite having a membrane that is impermeable to all but the smallest of metabolites, peroxisomes acquire their newly synthesized (cytosolic) matrix proteins…”
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The mammalian peroxisomal membrane is permeable to both GSH and GSSG – Implications for intraperoxisomal redox homeostasis by Ferreira, Maria J., Rodrigues, Tony A., Pedrosa, Ana G., Gales, Luís, Salvador, Armindo, Francisco, Tânia, Azevedo, Jorge E.

“…Despite the large amounts of H2O2 generated in mammalian peroxisomes, cysteine residues of intraperoxisomal proteins are maintained in a reduced state. The…”
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Editorial: Structural aspects of peroxisome biogenesis and functions by Skoneczny, Marek, Francisco, Tânia, Erdmann, Ralf, Gatsogiannis, Christos

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A Mechanistic Perspective on PEX1 and PEX6, Two AAA+ Proteins of the Peroxisomal Protein Import Machinery by Pedrosa, Ana G, Francisco, Tânia, Ferreira, Maria J, Rodrigues, Tony A, Barros-Barbosa, Aurora, Azevedo, Jorge E

“…In contrast to many protein translocases that use ATP or GTP hydrolysis as the driving force to transport proteins across biological membranes, the peroxisomal…”
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Identification of Ubiquitin-specific Protease 9X (USP9X) as a Deubiquitinase Acting on Ubiquitin-Peroxin 5 (PEX5) Thioester Conjugate by Grou, Cláudia P., Francisco, Tânia, Rodrigues, Tony A., Freitas, Marta O., Pinto, Manuel P., Carvalho, Andreia F., Domingues, Pedro, Wood, Stephen A., Rodríguez-Borges, José E., Sá-Miranda, Clara, Fransen, Marc, Azevedo, Jorge E.

“…Peroxin 5 (PEX5), the peroxisomal protein shuttling receptor, binds newly synthesized peroxisomal matrix proteins in the cytosol and promotes their…”
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A PEX7-Centered Perspective on the Peroxisomal Targeting Signal Type 2-Mediated Protein Import Pathway by Rodrigues, Tony A., Alencastre, Inês S., Francisco, Tânia, Brites, Pedro, Fransen, Marc, Grou, Cláudia P., Azevedo, Jorge E.

“…Peroxisomal matrix proteins are synthesized on cytosolic ribosomes and transported to the organelle by shuttling receptors. Matrix proteins containing a type 1…”
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A missense allele of PEX5 is responsible for the defective import of PTS2 cargo proteins into peroxisomes by Ali, Muhammad, Khan, Shahid Y., Rodrigues, Tony A., Francisco, Tânia, Jiao, Xiaodong, Qi, Hang, Kabir, Firoz, Irum, Bushra, Rauf, Bushra, Khan, Asma A., Mehmood, Azra, Naeem, Muhammad Asif, Assir, Muhammad Zaman, Ali, Muhammad Hassaan, Shahzad, Mohsin, Abu-Amero, Khaled K., Akram, Shehla Javed, Akram, Javed, Riazuddin, Sheikh, Riazuddin, Saima, Robinson, Michael L., Baes, Myriam, Azevedo, Jorge E., Hejtmancik, J. Fielding, Riazuddin, S. Amer

“…Peroxisomes, single-membrane intracellular organelles, play an important role in various metabolic pathways. The translocation of proteins from the cytosol to…”
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A Cargo-centered Perspective on the PEX5 Receptor-mediated Peroxisomal Protein Import Pathway by Francisco, Tânia, Rodrigues, Tony A., Freitas, Marta O., Grou, Cláudia P., Carvalho, Andreia F., Sá-Miranda, Clara, Pinto, Manuel P., Azevedo, Jorge E.

“…How the soluble receptor PEX5 delivers its cargoes to the peroxisome remains largely unknown. Results: Cargo translocation occurs after docking of the receptor…”
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Ubiquitin in the peroxisomal protein import pathway by Francisco, Tânia, Rodrigues, Tony A., Pinto, Manuel P., Carvalho, Andreia F., Azevedo, Jorge E., Grou, Cláudia P.

“…PEX5 is the shuttling receptor for newly synthesized peroxisomal matrix proteins. Alone, or with the help of an adaptor protein, this receptor binds…”
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The peroxisomal protein import machinery displays a preference for monomeric substrates by Freitas, Marta O., Francisco, Tânia, Rodrigues, Tony A., Lismont, Celien, Domingues, Pedro, Pinto, Manuel P., Grou, Cláudia P., Fransen, Marc, Azevedo, Jorge E.

“…Peroxisomal matrix proteins are synthesized on cytosolic ribosomes and transported by the shuttling receptor PEX5 to the peroxisomal membrane…”
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Protein transport into peroxisomes: Knowns and unknowns by Francisco, Tânia, Rodrigues, Tony A., Dias, Ana F., Barros‐Barbosa, Aurora, Bicho, Diana, Azevedo, Jorge E.

“…Peroxisomal matrix proteins are synthesized on cytosolic ribosomes and rapidly transported into the organelle by a complex machinery. The data gathered in…”
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Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6 and is unfolded during its dislocation into the cytosol by Pedrosa, Ana G., Francisco, Tânia, Bicho, Diana, Dias, Ana F., Barros-Barbosa, Aurora, Hagmann, Vera, Dodt, Gabriele, Rodrigues, Tony A., Azevedo, Jorge E.

“…PEX1 and PEX6 are two members of the ATPases associated with diverse cellular activities (AAA) family and the core components of the receptor export module of…”
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The Extraction Mechanism of Monoubiquitinated PEX5 from the Peroxisomal Membrane by Pedrosa, Ana G., Francisco, Tânia, Rodrigues, Tony A., Ferreira, Maria J., van der Heden van Noort, Gerbrand J., Azevedo, Jorge E.

“…[Display omitted] •Extraction of PEX5 from the peroxisome membrane requires its ubiquitination but the role of this modification is unclear.•We found that the…”
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PEX13 Enters the RING, Lives Fast, Dies Young by Rodrigues, Tony A., Francisco, Tânia, Azevedo, Jorge E.

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The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo by Dias, Ana F., Rodrigues, Tony A., Pedrosa, Ana G., Barros-Barbosa, Aurora, Francisco, Tânia, Azevedo, Jorge E.

“…A remarkable property of the machinery for import of peroxisomal matrix proteins is that it can accept already folded proteins as substrates. This import…”
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