Search Results - "Francis, P. T."

The cholinergic hypothesis of Alzheimer’s disease: a review of progress by Francis, Paul T, Palmer, Alan M, Snape, Michael, Wilcock, Gordon K

“…Alzheimer’s disease is one of the most common causes of mental deterioration in elderly people, accounting for around 50%-60% of the overall cases of dementia…”
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Cholinergic–serotonergic imbalance contributes to cognitive and behavioral symptoms in Alzheimer’s disease by Garcia-Alloza, M., Gil-Bea, F.J., Diez-Ariza, M., Chen, C.P.L.-H., Francis, P.T., Lasheras, B., Ramirez, M.J.

“…Neuropsychiatric symptoms seen in Alzheimer’s disease (AD) are not simply a consequence of neurodegeneration, but probably result from differential…”
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Age-related neurochemical and behavioural changes in D409V/WT GBA1 mouse: Relevance to lewy body dementia by Clarke, E., Jantrachotechatchawan, C., Buhidma, Y., Broadstock, M., Yu, L., Howlett, D., Aarsland, D., Ballard, C., Francis, P.T.

“…Heterozygous mutations in GBA1, the gene which encodes the lysosomal enzyme glucocerebrosidase (GCase), are a strong genetic risk factor for the development of…”
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Differential involvement of 5-HT1B/1D and 5-HT6 receptors in cognitive and non-cognitive symptoms in Alzheimer's disease by GARCIA-ALLOZA, M, HIRST, W. D, CHEN, C. P. L-H, LASHERAS, B, FRANCIS, P. T, RAMIREZ, M. J

“…Growing evidence suggests that a compromised serotonergic system plays an important role in the pathophysiology of Alzheimer's disease (AD). We assessed the…”
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Vesicular glutamate transporter and cognition in stroke: A case-control autopsy study by KIRVELL, S. L, ELLIOTT, M. S, KALARIA, R. N, HORTOBAGYI, T, BALLARD, C. G, FRANCIS, P. T

“…Vascular dementia (VaD) accounts for approximately 15%-20% of all dementias, but the relationship of progressive cognitive impairment to neurochemical changes…”
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Loss of serotonin 5-HT2A receptors in the postmortem temporal cortex correlates with rate of cognitive decline in Alzheimer's disease by LAI, M. K, TSANG, S. W, ALDER, J. T, KEENE, J, HOPE, T, ESIRI, M. M, FRANCIS, P. T, CHEN, C. P

“…Previous studies have demonstrated reductions of serotonin 5-HT 2A receptors in the neocortex of Alzheimer's disease (AD) patients. However, it is unclear…”
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Imbalance of a serotonergic system in frontotemporal dementia: implication for pharmacotherapy by Bowen, D. M., Procter, A. W., Mann, D. M. A., Snowden, J. S., Esiri, M. M., Neary, D., Francis, P. T.

“…Rationale Information is sparse on neurotransmitter deficiencies in frontotemporal dementia (FTD), in particular with reference to distinct histological…”
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Psychosis of Alzheimer's disease is associated with elevated muscarinic M2 binding in the cortex by LAI, M. K. P, LAI, O.-F, KEENE, J, ESIRI, M. M, FRANCIS, P. T, HOPE, T, CHEN, C. P. L.-H

“…Results from recent drug trials suggest a role for the cholinergic system in the manifestation of neuropsychiatric symptoms in AD. To date, the status of…”
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Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11α protein up-regulation in Alzheimer’s disease by Jacobs, E.H., Williams, R.J., Francis, P.T.

“…Besides formation of neurofibrillary tangles and neuron loss, the Alzheimer’s disease brain is characterized by neuritic plaques consisting of β-amyloid…”
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Cholinergic deficits contribute to behavioral disturbance in patients with dementia by MINGER, S. L, ESIRI, M. M, MCDONALD, B, KEENE, J, CARTER, J, HOPE, T, FRANCIS, P. T

“…Noncognitive behavioral changes such as depression, aggressive behavior, psychosis, and overactivity occur frequently in patients with dementia, in addition to…”
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Neurochemical features of frontotemporal dementia by Procter, A W, Qurne, M, Francis, P T

“…This study examines neurochemical measures of cholinergic, serotonergic and glutamatergic innervation in frontal temporal and parietal cerebral cortex from 16…”
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Immunocytochemical study of the dorsal and median raphe nuclei in patients with Alzheimer's disease prospectively assessed for behavioural changes by Chen, C. P. L. -H., Eastwood, S. L., Hope, T., McDonald, B., Francis, P. T., Esiri, M. M.

“…The dorsal and median raphe nuclei were examined with immunocytochemistry to display the 5‐HT neurones in 16 cases of post‐mortem‐proven Alzheimer’s disease…”
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Loss of [3H]4-DAMP binding to muscarinic receptors in the orbitofrontal cortex of Alzheimer’s disease patients with psychosis by Tsang, S. W. Y., Francis, P. T., Esiri, M. M., Wong, P. T. H., Chen, C. P. L. H., Lai, M. K. P.

“…Rationale Neuropsychiatric behaviours in Alzheimer’s disease (AD) patients have been associated with neocortical alterations of presynaptic cholinergic and…”
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Whole‐exome sequencing of the BDR cohort: evidence to support the role of the PILRA gene in Alzheimer's disease by Patel, T., Brookes, K. J., Turton, J., Chaudhury, S., Guetta‐Baranes, T., Guerreiro, R., Bras, J., Hernandez, D., Singleton, A., Francis, P. T., Hardy, J., Morgan, K.

“…Aim Late‐onset Alzheimer's disease (LOAD) accounts for 95% of all Alzheimer's cases and is genetically complex in nature. Overlapping clinical and…”
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Minimally invasive enteroscopically guided small bowel resection by Man, Tommy C H, Ng, K C, Wong, K W, Mok, Francis P T

“…Localisation of small bowel pathology is often difficult, especially intramural small bowel lesions. Even with the use of laparoscopy, visualisation of small…”
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Genetic variation in the 5-HT2A receptor and altered neocortical [ 3H] ketanserin binding in Alzheimer's disease by Holmes, C., McCulley, M., Nicoll, J.A.R., Alder, J.T., Chen, C.P.L.-H., Francis, P.T.

“…A common intronic single nucleotide polymorphism (T102C) in the 5-HT2A receptor gene is associated with the development of different neuropsychiatric symptoms,…”
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[3H]GR113808 binding to serotonin 5-HT4 receptors in the postmortem neocortex of Alzheimer disease: a clinicopathological study by LAI, M. K, TSANG, S. W, FRANCIS, P. T, ESIRI, M. M, HOPE, T, LAI, O. F, SPENCE, I, CHEN, C. P

“…Abnormalities in neural transmission of serotonin (5-HT) may play a role in both cognitive and neuropsychiatric features of Alzheimer disease (AD). We measured…”
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The effects of perturbed energy metabolism on the processing of amyloid precursor protein in PC12 cells by Webster, M T, Pearce, B R, Bowen, D M, Francis, P T

“…The mismetabolism of amyloid precursor protein (APP), favouring the production of A beta, is considered to be central to the pathogenesis of Alzheimer's…”
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NMDA‐induced glutamate and aspartate release from rat cortical pyramidal neurones: evidence for modulation by a 5‐HT1A antagonist by Dijk, Sas N., Francis, Paul T., Stratmann, Gary C., Bowen, David M.

“…1 We have investigated an aspect of the regulation of cortical pyramidal neurone activity. Microdialysis was used to assess whether topical application of…”
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Circumscribed Changes of the Cerebral Cortex in Neuropsychiatric Disorders of Later Life by Bowen, David M., Najlerahim, Abdolrahman, Procter, Andrew W., Francis, Paul T., Murphy, Elaine

“…The extent and distribution of biochemical abnormalities thought to reflect disorders of subpopulations of neurons have been determined in the cerebral cortex…”
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