Search Results - "Francis, Michael M"

Metacognitive Reflection and Insight Therapy for Early Psychosis: A preliminary study of a novel integrative psychotherapy by Vohs, Jenifer L., Leonhardt, Bethany L., James, Alison V., Francis, Michael M., Breier, Alan, Mehdiyoun, Nikki, Visco, Andrew C., Lysaker, Paul H.

“…Poor insight impedes treatment in early phase psychosis (EPP). This manuscript outlines preliminary findings of an investigation of the novel metacognitively…”
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Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components by Oliver, Devyn, Ramachandran, Shankar, Philbrook, Alison, Lambert, Christopher M, Nguyen, Ken C Q, Hall, David H, Francis, Michael M

“…The functional properties of neural circuits are defined by the patterns of synaptic connections between their partnering neurons, but the mechanisms that…”
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Effects of 12-month, double-blind N-acetyl cysteine on symptoms, cognition and brain morphology in early phase schizophrenia spectrum disorders by Breier, Alan, Liffick, Emily, Hummer, Tom A., Vohs, Jenifer L., Yang, Ziyi, Mehdiyoun, Nicole F., Visco, Andrew C., Metzler, Emmalee, Zhang, Ying, Francis, Michael M.

“…Currently approved medications for schizophrenia are relatively ineffective for negative symptoms and cognitive impairment. N-Acetyl Cysteine (NAC) is a…”
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Functional network connectivity in early-stage schizophrenia by Hummer, Tom A., Yung, Matthew G., Goñi, Joaquín, Conroy, Susan K., Francis, Michael M., Mehdiyoun, Nicole F., Breier, Alan

“…Schizophrenia is a disorder of altered neural connections resulting in impaired information integration. Whole brain assessment of within- and between-network…”
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Wnt Signaling Regulates Acetylcholine Receptor Translocation and Synaptic Plasticity in the Adult Nervous System by Jensen, Michael, Hoerndli, Frédéric J., Brockie, Penelope J., Wang, Rui, Johnson, Erica, Maxfield, Dane, Francis, Michael M., Madsen, David M., Maricq, Andres V.

“…The adult nervous system is plastic, allowing us to learn, remember, and forget. Experience-dependent plasticity occurs at synapses—the specialized points of…”
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Reactive Oxygen Species: Angels and Demons in the Life of a Neuron by Biswas, Kasturi, Alexander, Kellianne, Francis, Michael M

“…Reactive oxygen species (ROS) have emerged as regulators of key processes supporting neuronal growth, function, and plasticity across lifespan. At normal…”
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Monoaminergic orchestration of motor programs in a complex C. elegans behavior by Donnelly, Jamie L, Clark, Christopher M, Leifer, Andrew M, Pirri, Jennifer K, Haburcak, Marian, Francis, Michael M, Samuel, Aravinthan D T, Alkema, Mark J

“…Monoamines provide chemical codes of behavioral states. However, the neural mechanisms of monoaminergic orchestration of behavior are poorly understood. Touch…”
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The homeodomain transcriptional regulator DVE-1 directs a program for synapse elimination during circuit remodeling by Alexander, Kellianne D., Ramachandran, Shankar, Biswas, Kasturi, Lambert, Christopher M., Russell, Julia, Oliver, Devyn B., Armstrong, William, Rettler, Monika, Liu, Samuel, Doitsidou, Maria, Bénard, Claire, Walker, Amy K., Francis, Michael M.

“…The elimination of synapses during circuit remodeling is critical for brain maturation; however, the molecular mechanisms directing synapse elimination and its…”
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Repetitive Transcranial Magnetic Stimulation as a Therapeutic and Probe in Schizophrenia: Examining the Role of Neuroimaging and Future Directions by Brandt, Stephen J., Oral, Halimah Y., Arellano-Bravo, Carla, Plawecki, Martin H., Hummer, Tom A., Francis, Michael M.

“…Summary Schizophrenia is a complex condition associated with perceptual disturbances, decreased motivation and affect, and disrupted cognition. Individuals…”
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Local neuropeptide signaling modulates serotonergic transmission to shape the temporal organization of C. elegans egg-laying behavior by Banerjee, Navonil, Bhattacharya, Raja, Gorczyca, Michael, Collins, Kevin M, Francis, Michael M

“…Animal behaviors are often composed of distinct alternating behavioral states. Neuromodulatory signals are thought to be critical for establishing stable…”
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Correction: Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components by Oliver, Devyn, Ramachandran, Shankar, Philbrook, Alison, Lambert, Christopher M, Nguyen, Ken C Q, Hall, David H, Francis, Michael M

“…[This corrects the article DOI: 10.1371/journal.pgen.1010016.]…”
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Neurexin directs partner-specific synaptic connectivity in C. elegans by Philbrook, Alison, Ramachandran, Shankar, Lambert, Christopher M, Oliver, Devyn, Florman, Jeremy, Alkema, Mark J, Lemons, Michele, Francis, Michael M

“…In neural circuits, individual neurons often make projections onto multiple postsynaptic partners. Here, we investigate molecular mechanisms by which these…”
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Transcriptional Control of Synaptic Remodeling through Regulated Expression of an Immunoglobulin Superfamily Protein by He, Siwei, Philbrook, Alison, McWhirter, Rebecca, Gabel, Christopher V., Taub, Daniel G., Carter, Maximilian H., Hanna, Isabella M., Francis, Michael M., Miller, David M.

“…Neural circuits are actively remodeled during brain development, but the molecular mechanisms that trigger circuit refinement are poorly understood. Here, we…”
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A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior by Ramachandran, Shankar, Banerjee, Navonil, Bhattacharya, Raja, Lemons, Michele L, Florman, Jeremy, Lambert, Christopher M, Touroutine, Denis, Alexander, Kellianne, Schoofs, Liliane, Alkema, Mark J, Beets, Isabel, Francis, Michael M

“…Neuromodulators promote adaptive behaviors that are often complex and involve concerted activity changes across circuits that are often not physically…”
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A Tyramine-Gated Chloride Channel Coordinates Distinct Motor Programs of a Caenorhabditis elegans Escape Response by Pirri, Jennifer K., McPherson, Adam D., Donnelly, Jamie L., Francis, Michael M., Alkema, Mark J.

“…A key feature of escape responses is the fast translation of sensory information into a coordinated motor output. In C. elegans, anterior touch initiates a…”
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Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in Caenorhabditis elegans by Huang, Yung-Chi, Pirri, Jennifer K, Rayes, Diego, Gao, Shangbang, Mulcahy, Ben, Grant, Jeff, Saheki, Yasunori, Francis, Michael M, Zhen, Mei, Alkema, Mark J

“…Mutations in pre-synaptic voltage-gated calcium channels can lead to familial hemiplegic migraine type 1 (FHM1). While mammalian studies indicate that the…”
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A conserved dopamine-cholecystokinin signaling pathway shapes context-dependent Caenorhabditis elegans behavior by Bhattacharya, Raja, Touroutine, Denis, Barbagallo, Belinda, Climer, Jason, Lambert, Christopher M, Clark, Christopher M, Alkema, Mark J, Francis, Michael M

“…An organism's ability to thrive in changing environmental conditions requires the capacity for making flexible behavioral responses. Here we show that, in the…”
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Metacognition in Early Phase Psychosis: Toward Understanding Neural Substrates by Vohs, Jenifer L, Hummer, Tom A, Yung, Matthew G, Francis, Michael M, Lysaker, Paul H, Breier, Alan

“…Individuals in the early phases of psychotic illness have disturbed metacognitive capacity, which has been linked to a number of poor outcomes. Little is…”
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Evolutionary Conserved Role for TARPs in the Gating of Glutamate Receptors and Tuning of Synaptic Function by Wang, Rui, Walker, Craig S., Brockie, Penelope J., Francis, Michael M., Mellem, Jerry E., Madsen, David M., Maricq, Andres V.

“…Neurotransmission in the brain is critically dependent on excitatory synaptic signaling mediated by AMPA-class ionotropic glutamate receptors (AMPARs). AMPARs…”
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The Ror Receptor Tyrosine Kinase CAM-1 Is Required for ACR-16-Mediated Synaptic Transmission at the C. elegans Neuromuscular Junction by Francis, Michael M., Evans, Susan P., Jensen, Michael, Madsen, David M., Mancuso, Joel, Norman, Kenneth R., Maricq, Andres Villu

“…Nicotinic (cholinergic) neurotransmission plays a critical role in the vertebrate nervous system, underlies nicotine addiction, and nicotinic receptor…”
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