Search Results - "Francis, Jonathan W."

IGF-1:Tetanus toxin fragment C fusion protein improves delivery of IGF-1 to spinal cord but fails to prolong survival of ALS mice by Chian, Ru-Ju, Li, Jianhong, Ay, Ilknur, Celia, Samuel A, Kashi, Brenda B, Tamrazian, Eric, Matthews, Jonathan C, Bronson, Roderick T, Rossomando, Anthony, Pepinsky, R. Blake, Fishman, Paul S, Brown, Robert H, Francis, Jonathan W

“…Abstract To improve delivery of human insulin-like growth factor-1 (hIGF-1) to brain and spinal cord, we generated a soluble IGF-1:tetanus toxin fragment C…”
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VEGF increases blood–brain barrier permeability to Evans blue dye and tetanus toxin fragment C but not adeno-associated virus in ALS mice by Ay, Ilknur, Francis, Jonathan W, Brown, Robert H

“…Abstract Entry of most compounds into the CNS is impeded by the blood–brain barrier (BBB). Because vascular endothelial growth factor (VEGF) is important in…”
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Heterogeneity of Subcellular Localization and Electrophoretic Mobility of Survival Motor Neuron (SMN) Protein in Mammalian Neural Cells and Tissues by Francis, Jonathan W., Sandrock, Alfred W., Bhide, Pradeep G., Vonsattel, Jean-Paul, Brown, Robert H.

“…Spinal muscular atrophy is caused by defects in the survival motor neuron (SMN) gene. To better understand the patterns of expression of SMN in neuronal cells…”
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Insect GDNF:TTC fusion protein improves delivery of GDNF to mouse CNS by Li, Jianhong, Chian, Ru-Ju, Ay, Ilknur, Kashi, Brenda B., Celia, Samuel A., Tamrazian, Eric, Pepinsky, R. Blake, Fishman, Paul S., Brown, Robert H., Francis, Jonathan W.

“…With a view toward improving delivery of exogenous glial cell line-derived neurotrophic factor (GDNF) to CNS motor neurons in vivo, we evaluated the…”
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A glial cell line-derived neurotrophic factor (GDNF):tetanus toxin fragment C protein conjugate improves delivery of GDNF to spinal cord motor neurons in mice by Larsen, Kristin E., Benn, Susanna C., Ay, Ilknur, Chian, Ru-Ju, Celia, Samuel A., Remington, Mary P., Bejarano, Michelle, Liu, Meiqin, Ross, Joshua, Carmillo, Paul, Sah, Dinah, Phillips, Kester A., Sulzer, David, Pepinsky, R. Blake, Fishman, Paul S., Brown, Robert H., Francis, Jonathan W.

“…Glial cell line-derived neurotrophic factor (GDNF) has shown robust neuroprotective and neuroreparative activities in various animal models of Parkinson's…”
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Tetanus toxin fragment C fusion facilitates protein delivery to CNS neurons from cerebrospinal fluid in mice by Benn, Susanna C., Ay, Ilknur, Bastia, Elena, Chian, Ru‐Ju, Celia, Samuel A., Pepinsky, R. Blake, Fishman, Paul S., Brown, Robert H., Francis, Jonathan W.

“…To improve protein delivery to the CNS following intracerebroventricular administration, we compared the distribution of a human Cu/Zn superoxide…”
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Recombinant GDNF: Tetanus toxin fragment C fusion protein produced from insect cells by Li, Jianhong, Chian, Ru-Ju, Ay, Ilknur, Celia, Samuel A., Kashi, Brenda B., Tamrazian, Eric, Matthews, Jonathan C., Remington, Mary P., Pepinsky, R. Blake, Fishman, Paul S., Brown, Robert H., Francis, Jonathan W.

“…Glial cell line-derived neurotrophic factor (GDNF) has potent survival-promoting effects on CNS motor neurons in experimental animals. Its therapeutic efficacy…”
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A survival motor neuron:tetanus toxin fragment C fusion protein for the targeted delivery of SMN protein to neurons by Francis, Jonathan W., Figueiredo, Dayse, vanderSpek, Johanna C., Ayala, Laura M., Kim, Young Seon, Remington, Mary P., Young, Philip J., Lorson, Christian L., Ikebe, Shinichiro, Fishman, Paul S., Brown, Robert H.

“…Spinal muscular atrophy (SMA) is a degenerative disorder of spinal motor neurons caused by homozygous mutations in the survival motor neuron (SMN1) gene…”
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Survival motor neuron protein in the nucleolus of mammalian neurons by Wehner, Karen A, Ayala, Laura, Kim, Youngseon, Young, Philip J, Hosler, Betsy A, Lorson, Christian L, Baserga, Susan J, Francis, Jonathan W

“…Spinal muscular atrophy (SMA) is an inherited motor neuron disease caused by mutations in the survival motor neuron gene (SMN1). While it has been shown that…”
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Postischemic Infusion of Cu/Zn Superoxide Dismutase or SOD:Tet451 Reduces Cerebral Infarction Following Focal Ischemia/Reperfusion in Rats by Francis, Jonathan W., Ren, JingMei, Warren, Lisl, Brown, Robert H., Finklestein, Seth P.

“…Oxygen-free radicals play a major role in neuronal cell injury following cerebral ischemia/reperfusion. The free-radical scavenging enzyme, Cu/Zn superoxide…”
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CuZn Superoxide Dismutase (SOD-1):Tetanus Toxin Fragment C Hybrid Protein for Targeted Delivery of SOD-1 to Neuronal Cells (∗) by Francis, Jonathan W., Hosler, Betsy A., Brown, Robert H., Fishman, Paul S.

“…Increased levels of CuZn superoxide dismutase (SOD-1) are cytoprotective in experimental models of neurological disorders associated with free radical toxicity…”
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The Ewing's sarcoma protein interacts with the Tudor domain of the survival motor neuron protein by Young, Philip J, Francis, Jonathan W, Lince, Diane, Coon, Keith, Androphy, Elliot J, Lorson, Christian L

“…The survival motor neuron ( SMN) gene is the spinal muscular atrophy (SMA) determining gene. Here we report that the SMN protein product interacts in vitro and…”
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Neuroglial responses to the dopaminergic neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mouse striatum by Francis, Jonathan W., Von Visger, Jon, Markelonis, George J., Oh, Tae H.

“…We have studied the reactive responses of both astrocytes and microglia to dopaminergic denervation of the Striatum by MPTP. Following MPTP treatment,…”
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Cholinergic activity of acetylenic imidazoles and related compounds by Moon, Malcolm W, Chidester, Connie G, Heier, Richard F, Morris, Jeanette K, Collins, R. James, Russell, Roland R, Francis, Jonathan W, Sage, G. Patrick, Sethy, Vimala H

“…A series of acetylenic imidazoles related to oxotremorine (1a) were prepared and evaluated as cholinergic agents with in vitro binding assays and in vivo…”
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The effect of proadifen on the metabolism of adinazolam by Sethy, V H, Francis, J W, Day, J S

“…Binding affinities of adinazolam and its metabolite mono-N-demethyladinazolam, U-42352, to the brain tissue are not altered by the presence of proadifen…”
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Enhancement of diphtheria toxin potency by replacement of the receptor binding domain with tetanus toxin C-fragment : A potential vector for delivering heterologous proteins to neurons by FRANCIS, J. W, BROWN, R. H, FIGUEIREDO, D, REMINGTON, T. P, CASTILLO, O, SCHWARZSCHILD, M. A, FISHMAN, P. S, MURPHY, J. R, VANDERSPEK, J. C

“…This study describes the expression, purification, and characterization of a recombinant fusion toxin, DAB(389)TTC, composed of the catalytic and membrane…”
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Enhancement of Diphtheria Toxin Potency by Replacement of the Receptor Binding Domain with Tetanus Toxin C‐Fragment by Francis, Jonathan W., Brown, Robert H., Figueiredo, Dayse, Remington, Mary P., Castillo, Orlando, Schwarzschild, Michael A., Fishman, Paul S., Murphy, John R., VanderSpek, Johanna C.

“…: This study describes the expression, purification, and characterization of a recombinant fusion toxin, DAB389TTC, composed of the catalytic and membrane…”
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Interleukin-1-beta and tumor necrosis factor-alpha increase peripheral-type benzodiazepine binding sites in cultured polygonal astrocytes by Oh, Y J, Francis, J W, Markelonis, G J, Oh, T H

“…Peripheral-type benzodiazepine binding sites (PTBBS) are markedly increased in the injured CNS. Astrocytes appear to be the primary cell type which express…”
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Pharmacokinetics of buspirone as determined by ex vivo (3H)-DPAT binding by Sethy, V H, Francis, J W

“…Ex vivo (3H)-8-hydroxy-2-(di-n-propylamino)-tetraline ((3H)-DPAT) binding to the hippocampus has been utilized to determine the pharmacokinetic parameters of…”
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