Search Results - "Francis, J Nicholas"

Prevention and treatment of SHIVAD8 infection in rhesus macaques by a potent D-peptide HIV entry inhibitor by Nishimura, Yoshiaki, Francis, J. Nicholas, Donau, Olivia K., Jesteadt, Eric, Sadjadpour, Reza, Smith, Amanda R., Seaman, Michael S., Welch, Brett D., Martin, Malcolm A., Kay, Michael S.

“…Cholesterol-PIE12-trimer (CPT31) is a potent D-peptide HIV entry inhibitor that targets the highly conserved gp41 N-peptide pocket region. CPT31 exhibited…”
Get full text

Design of a Potent d-Peptide HIV-1 Entry Inhibitor with a Strong Barrier to Resistance by WELCH, Brett D, FRANCIS, J. Nicholas, ROOT, Michael J, KAY, Michael S, REDMAN, Joseph S, PAUL, Suparna, WEINSTOCK, Matthew T, REEVES, Jacqueline D, LIE, Yolanda S, WHITBY, Frank G, ECKERT, Debra M, HILL, Christopher P

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Chemical synthesis of Shiga toxin subunit B using a next-generation traceless "helping hand" solubilizing tag by Fulcher, James M, Petersen, Mark E, Giesler, Riley J, Cruz, Zachary S, Eckert, Debra M, Francis, J Nicholas, Kawamoto, Eric M, Jacobsen, Michael T, Kay, Michael S

“…The application of solid-phase peptide synthesis and native chemical ligation in chemical protein synthesis (CPS) has enabled access to synthetic proteins that…”
Get more information

Pharmacokinetic and Chemical Synthesis Optimization of a Potent d‑Peptide HIV Entry Inhibitor Suitable for Extended-Release Delivery by Redman, Joseph S, Francis, J. Nicholas, Marquardt, Robert, Papac, Damon, Mueller, Alan L, Eckert, Debra M, Welch, Brett D, Kay, Michael S

“…Peptides often suffer from short in vivo half-lives due to proteolysis and renal clearance that limit their therapeutic potential in many indications,…”
Get full text

Characterization of resistance to a potent D-peptide HIV entry inhibitor by Smith, Amanda R, Weinstock, Matthew T, Siglin, Amanda E, Whitby, Frank G, Francis, J Nicholas, Hill, Christopher P, Eckert, Debra M, Root, Michael J, Kay, Michael S

“…PIE12-trimer is a highly potent D-peptide HIV-1 entry inhibitor that broadly targets group M isolates. It specifically binds the three identical conserved…”
Get full text

Fabrication and Characterization of Nanoporous Gold Electrodes for Sensor Applications by Francis, Nicholas J., Knospe, Carl R.

“…Nanoporous gold electrodes are fabricated by etching white gold leaf in nitric acid. Samples of various thickness and alloy composition are used and etch time…”
Get full text

Protease-resistant peptide design-empowering nature's fragile warriors against HIV by Weinstock, Matthew T., Francis, J. Nicholas, Redman, Joseph S., Kay, Michael S.

“…Peptides have great potential as therapeutic agents, but their use is often limited by susceptibility to proteolysis and their resulting in vivo fragility. In…”
Get full text

Pigment Analysis of “Candidatus Chlorothrix halophila,” a Green Filamentous Anoxygenic Phototrophic Bacterium by LE OLSON, Tien, VAN DE MEENE, Allison M. L, FRANCIS, J. Nicholas, PIERSON, Beverly K, BLANKENSHIP, Robert E

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Design of a Modular Tetrameric Scaffold for the Synthesis of Membrane-Localized d-Peptide Inhibitors of HIV-1 Entry by Francis, J. Nicholas, Redman, Joseph S, Eckert, Debra M, Kay, Michael S

“…The highly conserved HIV-1 gp41 “pocket” region is a promising target for inhibiting viral entry. PIE12-trimer is a protease-resistant trimeric d-peptide…”
Get full text