Search Results - "Franceus, Jorick"

Sucrose Phosphorylase and Related Enzymes in Glycoside Hydrolase Family 13: Discovery, Application and Engineering by Franceus, Jorick, Desmet, Tom

“…Sucrose phosphorylases are carbohydrate-active enzymes with outstanding potential for the biocatalytic conversion of common table sugar into products with…”
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CANDy: Automated analysis of domain architectures in carbohydrate-active enzymes by Windels, Alex, Franceus, Jorick, Pleiss, Jürgen, Desmet, Tom

“…Carbohydrate-active enzymes (CAZymes) can be found in all domains of life and play a crucial role in metabolic and physiological processes. CAZymes often…”
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β-Glucan phosphorylases in carbohydrate synthesis by Ubiparip, Zorica, De Doncker, Marc, Beerens, Koen, Franceus, Jorick, Desmet, Tom

“…β-Glucan phosphorylases are carbohydrate-active enzymes that catalyze the reversible degradation of β-linked glucose polymers, with outstanding potential for…”
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Thermostable alpha-glucan phosphorylases: characteristics and industrial applications by Ubiparip, Zorica, Beerens, Koen, Franceus, Jorick, Vercauteren, Ronny, Desmet, Tom

“…α-Glucan phosphorylases (α-GPs) catalyze the reversible phosphorolysis of α-1,4-linked polysaccharides such as glycogen, starch, and maltodextrins, therefore…”
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Discovery of a Kojibiose Hydrolase by Analysis of Specificity-Determining Correlated Positions in Glycoside Hydrolase Family 65 by De Beul, Emma, Jongbloet, Alana, Franceus, Jorick, Desmet, Tom

“…The Glycoside Hydrolase Family 65 (GH65) is an enzyme family of inverting α-glucoside phosphorylases and hydrolases that currently contains 10 characterized…”
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Synthesis, trehalase hydrolytic resistance and inhibition properties of 4- and 6-substituted trehalose derivatives by Dhaene, Shari, Van der Eycken, Johan, Beerens, Koen, Franceus, Jorick, Desmet, Tom, Caroen, Jurgen

“…Although trehalose has recently gained interest because of its pharmaceutical potential, its clinical use is hampered due to its low bioavailability. Hence,…”
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Structural Comparison of a Promiscuous and a Highly Specific Sucrose 6F-Phosphate Phosphorylase by Franceus, Jorick, Capra, Nikolas, Desmet, Tom, Thunnissen, Andy-Mark W.H.

“…In family GH13 of the carbohydrate-active enzyme database, subfamily 18 contains glycoside phosphorylases that act on α-sugars and glucosides. Because their…”
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Chemoenzymatic Approach toward the Synthesis of 3‑O‑(α/β)-Glucosylated 3‑Hydroxy-β-lactams by Decuyper, Lena, Franceus, Jorick, Dhaene, Shari, Debruyne, Maarten, Vandoorne, Kevin, Piens, Nicola, Dewitte, Griet, Desmet, Tom, D’hooghe, Matthias

“…Glycosylation significantly alters the biological and physicochemical properties of small molecules. β-Lactam alcohols comprise eligible substrates for such a…”
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Insertions and deletions in protein evolution and engineering by Savino, Simone, Desmet, Tom, Franceus, Jorick

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The many functions of carbohydrate-active enzymes in family GH65: diversity and application by De Beul, Emma, Franceus, Jorick, Desmet, Tom

“…Glycoside Hydrolase family 65 (GH65) is a unique family of carbohydrate-active enzymes. It is the first protein family to bring together glycoside hydrolases,…”
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Building mutational bridges between carbohydrate-active enzymes by Franceus, Jorick, Lormans, Jolien, Desmet, Tom

“…The commercial value of specialty carbohydrates and glycosylated compounds has sparked considerable interest in the synthetic potential of carbohydrate-active…”
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Strategies for the synthesis of the osmolyte glucosylglycerate and its precursor glycerate by Allaert, Yentl, Leyder, Arthur, Franceus, Jorick, Desmet, Tom

“…Glycosidic osmolytes are widespread natural compounds that protect microorganisms and their macromolecules from the deleterious effects of various…”
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Glucosylglycerate Phosphorylase, an Enzyme with Novel Specificity Involved in Compatible Solute Metabolism by Franceus, Jorick, Pinel, Denise, Desmet, Tom

“…Family GH13_18 of the carbohydrate-active enzyme database consists of retaining glycoside phosphorylases that have attracted interest with their potential for…”
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Engineering of a Thermostable Biocatalyst for the Synthesis of 2‐O‐Glucosylglycerol by Franceus, Jorick, Ubiparip, Zorica, Beerens, Koen, Desmet, Tom

“…2‐O‐Glucosylglycerol is accumulated by various bacteria and plants in response to environmental stress. It is widely applied as a bioactive moisturising…”
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High-yield synthesis of 2-O-α-d-glucosyl-d-glycerate by a bifunctional glycoside phosphorylase by Franceus, Jorick, Steynen, Manon, Allaert, Yentl, Bredael, Kato, D’hooghe, Matthias, Desmet, Tom

“…Osmolytes are produced by various microorganisms as a defense mechanism to protect cells and macromolecules from damage caused by external stresses in harsh…”
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Converting Bulk Sugars into Functional Fibers: Discovery and Application of a Thermostable β‑1,3-Oligoglucan Phosphorylase by De Doncker, Marc, Vleminckx, Sofie, Franceus, Jorick, Vercauteren, Ronny, Desmet, Tom

“…Despite their broad application potential, the widespread use of β-1,3-glucans has been hampered by the high cost and heterogeneity associated with current…”
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Front Cover: Engineering of a Thermostable Biocatalyst for the Synthesis of 2‐O‐Glucosylglycerol (ChemBioChem 18/2021) by Franceus, Jorick, Ubiparip, Zorica, Beerens, Koen, Desmet, Tom

“…Enzyme engineering for the synthesis of a cosmetic ingredient: The osmolyte 2‐O‐glucosylglycerol is widely applied as a bioactive moisturizing ingredient in…”
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Correlated positions in protein evolution and engineering by Franceus, Jorick, Verhaeghe, Tom, Desmet, Tom

“…Statistical analysis of a protein multiple sequence alignment can reveal groups of positions that undergo interdependent mutations throughout evolution. At…”
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Identification of mercaptoacetamide-based HDAC6 inhibitors via a lean inhibitor strategy: screening, synthesis, and biological evaluation by Geurs, Silke, Clarisse, Dorien, Baele, Freya, Franceus, Jorick, Desmet, Tom, De Bosscher, Karolien, D'hooghe, Matthias

“…Non-selective inhibition of different histone deacetylase enzymes by hydroxamic acid-based drugs causes severe side effects when used as a (long-term) cancer…”
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Evolution of Phosphorylases from N -Acetylglucosaminide Hydrolases in Family GH3 by Franceus, Jorick, Lormans, Jolien, Cools, Lore, D’hooghe, Matthias, Desmet, Tom

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