Search Results - "Francescut, Lorenza"
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Protective role for properdin in progression of experimental murine atherosclerosis
Published in PloS one (25-03-2014)“…Genetic, dietary and immune factors contribute to the pathogenesis of atherosclerosis in humans and mice. Complement activation is an integral part of the…”
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2
Abstract 11593: Thrombus Formation Under Flow is Inhibited by the Mechanosensitive Cation Channel Blockers GsMTx-4 Peptide and Gadolinium Chloride
Published in Circulation (New York, N.Y.) (10-11-2015)“…IntroductionIon channels contribute significantly to platelet physiology, including control of Ca as a second messenger. Although there is a clear link between…”
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Journal Article -
3
Monocyte-derived macrophages matured under prolonged hypoxia transcriptionally up-regulate HIF-1α mRNA
Published in Immunobiology (1979) (01-07-2011)“…Abstract This study tested the hypothesis that prolonged severe hypoxia during monocyte to macrophage differentiation results in macrophages with a pattern of…”
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Journal Article -
4
The Role of Complement in the Development and Manifestation of Murine Atherogenic Inflammation: Novel Avenues
Published in Journal of innate immunity (01-01-2012)“…Atherosclerosis is a chronic progressive inflammatory disease which manifests in the arterial vascular tree. It is a major cause of cardiovascular morbidity…”
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Journal Article -
5
Septicaemia models using Streptococcus pneumoniae and Listeria monocytogenes: understanding the role of complement properdin
Published in Medical microbiology and immunology (01-08-2014)“…Streptococcus pneumoniae and Listeria monocytogenes , pathogens which can cause severe infectious disease in human, were used to infect properdin-deficient and…”
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Journal Article -
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Role of hypoxia and toll-like receptor ligands in matrix metalloproteinase-7 regulation in primary human macrophages
Published 01-01-2012“…Many solid tumours and other pathological sites such as infected wounds are characterised by hypoxic regions (defined by an O2 tension of <1%), which are often…”
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Dissertation