Search Results - "Francesca Faggioli"

Chromosome-specific accumulation of aneuploidy in the aging mouse brain by FAGGIOLI, Francesca, TAO WANG, VIJG, Jan, MONTAGNA, Cristina

“…Chromosomal aneuploidy, the gain or loss of whole chromosomes, is a hallmark of pathological conditions and a causal factor of birth defects and cancer. A…”
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B lymphocytes limit senescence‐driven fibrosis resolution and favor hepatocarcinogenesis in mouse liver injury by Faggioli, Francesca, Palagano, Eleonora, Di Tommaso, Luca, Donadon, Matteo, Marrella, Veronica, Recordati, Camilla, Mantero, Stefano, Villa, Anna, Vezzoni, Paolo, Cassani, Barbara

“…Hepatocellular carcinoma (HCC) is a frequent neoplasia and a leading cause of inflammation‐related cancer mortality. Despite that most HCCs arise from…”
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Whole Chromosome Instability induces senescence and promotes SASP by Andriani, Grasiella Angelina, Almeida, Vinnycius Pereira, Faggioli, Francesca, Mauro, Maurizio, Tsai, Wanxia Li, Santambrogio, Laura, Maslov, Alexander, Gadina, Massimo, Campisi, Judith, Vijg, Jan, Montagna, Cristina

“…Age-related accumulation of ploidy changes is associated with decreased expression of genes controlling chromosome segregation and cohesin functions. To…”
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Single-cell analysis of ploidy and centrosomes underscores the peculiarity of normal hepatocytes by Faggioli, Francesca, Vezzoni, Paolo, Montagna, Cristina

“…Polyploidization is the most well recognized feature of the liver. Yet, a quantitative and behavioral analysis of centrosomes and DNA content in normal…”
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Cellular Senescence, a Novel Area of Investigation for Metastatic Diseases by Faggioli, Francesca, Velarde, Michael C, Wiley, Christopher D

“…Metastasis is a systemic condition and the major challenge among cancer types, as it can lead to multiorgan vulnerability. Recently, attention has been drawn…”
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Chromosome transplantation as a novel approach for correcting complex genomic disorders by Paulis, Marianna, Castelli, Alessandra, Susani, Lucia, Lizier, Michela, Lagutina, Irina, Focarelli, Maria Luisa, Recordati, Camilla, Uva, Paolo, Faggioli, Francesca, Neri, Tui, Scanziani, Eugenio, Galli, Cesare, Lucchini, Franco, Villa, Anna, Vezzoni, Paolo

“…Genomic disorders resulting from large rearrangements of the genome remain an important unsolved issue in gene therapy. Chromosome transplantation, defined as…”
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Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts by Neri, Tui, Muggeo, Sharon, Paulis, Marianna, Caldana, Maria Elena, Crisafulli, Laura, Strina, Dario, Focarelli, Maria Luisa, Faggioli, Francesca, Recordati, Camilla, Scaramuzza, Samantha, Scanziani, Eugenio, Mantero, Stefano, Buracchi, Chiara, Sobacchi, Cristina, Lombardo, Angelo, Naldini, Luigi, Vezzoni, Paolo, Villa, Anna, Ficara, Francesca

“…Autosomal recessive osteopetrosis is a human bone disease mainly caused by TCIRG1 gene mutations that prevent osteoclasts resorbing activity, recapitulated by…”
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Role of the Spacer of Cationic Gemini Amphiphiles in the Condensation of DNA by Bombelli, Cecilia, Borocci, Stefano, Diociaiuti, Marco, Galantini, Luciano, Luciani, Paola, Mancini, Giovanna, Sacco, Maria Grazia

“…The condensation of calf thymus DNA into the cholesteric-like ψ-phase was observed by circular dichroism in liposome suspensions formulated with specific…”
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Rescue of ATPa3-Deficient Murine Malignant Osteopetrosis by Hematopoietic Stem Cell Transplantation in utero by Frattini, Annalisa, Blair, Harry C., Maria Grazia Sacco, Cerisoli, Francesco, Francesca Faggioli, Enrica Mira Catò, Alessandra Pangrazio, Antonio Musio, Francesca Rucci, Sobacchi, Cristina, Allison C. Sharrow, Kalla, Sara E., Bruzzone, Maria Grazia, Roberto Colombo, Magli, Maria Cristina, Vezzoni, Paolo, Villa, Anna

“…Autosomal recessive osteopetrosis (ARO) is a paradigm for genetic diseases that cause severe, often irreversible, defects before birth. In ARO, osteoclasts…”
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Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis by Garbarino, Ombretta, Lambroia, Luca, Basso, Gianluca, Marrella, Veronica, Franceschini, Barbara, Soldani, Cristiana, Pasqualini, Fabio, Giuliano, Desiree, Costa, Guido, Peano, Clelia, Barbarossa, Davide, Annarita, Destro, Salvati, Andreina, Terracciano, Luigi, Torzilli, Guido, Donadon, Matteo, Faggioli, Francesca

“…Hepatic metastasis is a clinical challenge for colorectal cancer (CRC). Senescent cancer cells accumulate in CRC favoring tumor dissemination. Whether this…”
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Four-color FISH for the detection of low-level aneuploidy in interphase cells by Faggioli, Francesca, Vijg, Jan, Montagna, Cristina

“…FISH (fluorescent in situ hybridization) is a molecular cytogenetic technique established in the early 1980s that allows for the detection of DNA copy number…”
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Chromosomal aneuploidy in the aging brain by Faggioli, Francesca, Vijg, Jan, Montagna, Cristina

“…► Whole chromosome aneuploidy is a common feature observed in the development of the mammalian nervous system. ► Aneuploidy is a mechanism that could generate…”
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Featured Cover by Garbarino, Ombretta, Lambroia, Luca, Basso, Gianluca, Marrella, Veronica, Franceschini, Barbara, Soldani, Cristiana, Pasqualini, Fabio, Giuliano, Desiree, Costa, Guido, Peano, Clelia, Barbarossa, Davide, Annarita, Destro, Salvati, Andreina, Terracciano, Luigi, Torzilli, Guido, Donadon, Matteo, Faggioli, Francesca

“…Cover legend: The cover image is based on the Research Article Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis by…”
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Cell fusion in the liver, revisited by Lizier, Michela, Castelli, Alessandra, Montagna, Cristina, Lucchini, Franco, Vezzoni, Paolo, Faggioli, Francesca

“…There is wide agreement that cell fusion is a physiological process in cells in mammalian bone, muscle and placenta. In other organs, such as the cerebellum,…”
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Whole chromosome aneuploidy in the brain of Bub1b super(H/H) and Ercc1 super(-/ Delta 7) mice by Andriani, Grasiella A, Faggioli, Francesca, Baker, Darren, Dolle, Martijn ET, Sellers, Rani S, Hebert, Jean M, Van Steeg, Harry, Hoeijmakers, Jan, Vijg, Jan, Montagna, Cristina

“…High levels of aneuploidy have been observed in disease-free tissues, including post-mitotic tissues such as the brain. Using a quantitative…”
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Whole chromosome aneuploidy in the brain of Bub1b H/H and Ercc1 −/Δ7 mice by Andriani, Grasiella A., Faggioli, Francesca, Baker, Darren, Dollé, Martijn E.T., Sellers, Rani S., Hébert, Jean M., Van Steeg, Harry, Hoeijmakers, Jan, Vijg, Jan, Montagna, Cristina

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Cell fusion is a physiological process in mouse liver by Faggioli, Francesca, Sacco, Maria Grazia, Susani, Lucia, Montagna, Cristina, Vezzoni, Paolo

“…A large portion of hepatocytes are polyploid cells, thought to arise through endoduplication followed by aborted cytokinesis. However, several recent reports…”
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Whole chromosome aneuploidy in the brain of Bub1bH/H and Ercc1-/Δ7 mice by Andriani, Grasiella A, Faggioli, Francesca, Baker, Darren, Dollé, Martijn E T, Sellers, Rani S, Hébert, Jean M, Van Steeg, Harry, Hoeijmakers, Jan, Vijg, Jan, Montagna, Cristina

“…High levels of aneuploidy have been observed in disease-free tissues, including post-mitotic tissues such as the brain. Using a quantitative…”
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Efficient Transfection of DNA by Liposomes Formulated with Cationic Gemini Amphiphiles by Bombelli, Cecilia, Faggioli, Francesca, Luciani, Paola, Mancini, Giovanna, Sacco, Maria Grazia

“…Cationic liposomes formulated with neutral 1,2-dimyristoyl-sn-glycero-3-phosphocholine and cationic gemini surfactants were used for transfecting different…”
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PEGylated Lipoplexes:  Preparation Protocols Affecting DNA Condensation and Cell Transfection Efficiency by Bombelli, Cecilia, Faggioli, Francesca, Luciani, Paola, Mancini, Giovanna, Sacco, Maria Grazia

“…The inclusion of poly(ethylene glycol) monolaurate in liposomes formulated with dimyristoyl-sn-glycero-3-phosphocholine and certain cationic gemini surfactants…”
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