Search Results - "Francesca Armentano, Maria"
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Novel wild type and mutate HIV-1 protease inhibitors containing heteroaryl carboxamides in P2: Synthesis, biological evaluations and in silico ADME prediction
Published in Results in Chemistry (01-12-2023)“…[Display omitted] The Virus HIV-1 infection still represents a serious disease even if actually it is transformed in chronic pathology. Considering the crucial…”
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Calorimetry and FTIR reveal the ability of URG7 protein to modify the aggregation state of both cell lysate and amylogenic α-synuclein
Published in AIMS biophysics (01-01-2020)“…Differential scanning calorimetry and FITR analyses allowed to investigate the role of URG7 (up-regulated gene clone 7) protein involved in the development of…”
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Targeting unfolded protein response reverts ER stress and ER Ca2+ homeostasis in cardiomyocytes expressing the pathogenic variant of Lamin A/C R321X
Published in Journal of translational medicine (22-05-2023)“…Abstract Background We previously demonstrated that an Italian family affected by a severe dilated cardiomyopathy (DCM) with history of sudden deaths at young…”
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Neuroprotective Effect of Antiapoptotic URG7 Protein on Human Neuroblastoma Cell Line SH-SY5Y
Published in International journal of molecular sciences (29-12-2023)“…Up-regulated Gene clone 7 (URG7) is a protein localized in the endoplasmic reticulum (ER) and overexpressed in liver cells upon hepatitis B virus (HBV)…”
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PEGylated Liposomes Loaded with Carbamate Inhibitor ANP0903 Trigger Apoptosis by Enhancing ER Stress in HepG2 Cancer Cells
Published in International journal of molecular sciences (25-02-2023)“…Liver cancer is one of the most common causes of cancer death worldwide. In recent years, substantial progress has been made in the development of systemic…”
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Phytochemical Profile of Capsicum annuum L. cv Senise, Incorporation into Liposomes, and Evaluation of Cellular Antioxidant Activity
Published in Antioxidants (15-05-2020)“…Overproduction of oxidants in the human body is responsible for oxidative stress, which is associated with several diseases. High intake of vegetables and…”
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A Comparative Study on Phytochemical Profiles and Biological Activities of Sclerocarya birrea (A.Rich.) Hochst Leaf and Bark Extracts
Published in International journal of molecular sciences (08-01-2018)“…(A.Rich.) Hochst (Anacardiaceae) is a savannah tree that has long been used in sub-Saharan Africa as a medicinal remedy for numerous ailments. The purpose of…”
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Advances in Azorella glabra Wedd. Extract Research: In Vitro Antioxidant Activity, Antiproliferative Effects on Acute Myeloid Leukemia Cells and Bioactive Compound Characterization
Published in Molecules (Basel, Switzerland) (22-10-2020)“…Azorella glabra Wedd. (AG) is traditionally used to treat gonorrhea or kidney’s problems. The antioxidant, antidiabetic, anticholinesterase and in vitro…”
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Future in the Past: Azorella glabra Wedd. as a Source of New Natural Compounds with Antiproliferative and Cytotoxic Activity on Multiple Myeloma Cells
Published in International journal of molecular sciences (26-10-2018)“…Multiple myeloma (MM) is the second most common hematologic malignancy and, although the development of novel agents has improved survival of patients, to…”
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10
Hura crepitans L. Extract: Phytochemical Characterization, Antioxidant Activity, and Nanoformulation
Published in Pharmaceutics (15-06-2020)“…The purpose of this study was to improve the knowledge on Hura crepitans L., a plant belonging to the Euphorbiaceae family that, on the one hand, is known to…”
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11
ABCC6 knockdown in HepG2 cells induces a senescent-like cell phenotype
Published in Cellular & molecular biology letters (04-04-2017)“…Pseudoxanthoma elasticum (PXE) is characterized by progressive ectopic mineralization of elastic fibers in dermal, ocular and vascular tissues. No effective…”
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Two Novel Precursors of the HIV-1 Protease Inhibitor Darunavir Target the UPR/Proteasome System in Human Hepatocellular Carcinoma Cell Line HepG2
Published in Cells (Basel, Switzerland) (06-11-2021)“…Several pre-clinical and clinical reports suggest that HIV-1 protease inhibitors, in addition to the antiretroviral properties, possess pleiotropic…”
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Routes to Covalent Catalysis by Reactive Selection for Nascent Protein Nucleophiles
Published in Journal of the American Chemical Society (26-12-2007)“…Reactivity-based selection strategies have been used to enrich combinatorial libraries for encoded biocatalysts having revised substrate specificity or altered…”
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Astaxanthin anticancer effects are mediated through multiple molecular mechanisms: A systematic review
Published in Pharmacological research (01-05-2020)“…[Display omitted] During the latest decades, the interest on the effectiveness of natural compounds and their impact on human health constantly increased,…”
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Effect of quercetin and resveratrol co-incorporated in liposomes against inflammatory/oxidative response associated with skin cancer
Published in International journal of pharmaceutics (20-11-2016)“…[Display omitted] The present investigation reports the development of liposomes for the co-delivery of naturally occurring polyphenols, namely quercetin and…”
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16
Identification of a New Splice Variant of the Human ABCC6 Transporter
Published in Research Letters in Biochemistry (01-01-2008)“…ABCC6 is a member of the adenosine triphosphate-binding cassette (ABC) gene subfamily C that encodes a protein (MRP6) involved in active transport of…”
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The P-glycoprotein inhibitor diltiazem-like 8-(4-chlorophenyl)-5-methyl-8-[(2Z)-pent-2-en-1-yloxy]-8H-[1,2,4]oxadiazolo[3,4-c][1,4]thiazin-3-one inhibits esterase activity and H3 histone acetylation
Published in European journal of medicinal chemistry (15-02-2019)“…With the aim to reduce multidrug resistance several molecules were synthesized and tested for their ability to inhibit ATP-binding cassette (ABC) proteins,…”
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Phytochemical analysis, antioxidant and hypoglycemic activities of a methanol extract from Stachys brachyclada de Noé ex Coss. leaves
Published in Natural product research (17-12-2023)“…Stachys brachyclada de Noé ex Coss. (Lamiaceae) is a quite rare medicinal plant endemic to the Mediterranean basin. In this study, seven secondary metabolites…”
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New heteroaryl carbamates: Synthesis and biological screening in vitro and in mammalian cells of wild-type and mutant HIV-protease inhibitors
Published in Bioorganic & medicinal chemistry (01-05-2019)“…[Display omitted] New heteroaryl HIV-protease inhibitors bearing a carbamoyl spacer were synthesized in few steps and high yield, from commercially available…”
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New insights into the roles of the N-terminal region of the ABCC6 transporter
Published in Journal of bioenergetics and biomembranes (01-06-2016)“…ABCC6 is a human ATP binding cassette (ABC) transporter of the plasma membrane associated with Pseudoxanthoma elasticum (PXE), an autosomal recessive disease…”
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