A combined treatment for self-traumatic chronic skin lesions associated with post-surgical neuropathic pain in a domestic cat: a pharmacological and cold atmospheric plasma approach

Cold atmospheric plasma (CAP) has been employed as a therapy against both acute and chronic skin lesions, contaminated or not, and has effects on angiogenesis and reepithelialization promoting healing. In this context, the present study aimed to evaluate the effects of a CAP jet associated with phar...

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Published in:	Veterinary research communications Vol. 48; no. 5; pp. 3263 - 3270
Main Authors:	de Moura, Carlos Eduardo Bezerra, Francelino, Luiz Emanuel Campos, da Silva, Guilherme Ramon Vieira, Júnior, Clodomiro Alves, Façanha, Débora Andréa Evangelista, Nunes, Talyta Lins, de Paula, Valéria Veras
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 01-10-2024 Springer Nature B.V
Subjects:	Amitriptyline Amitriptyline - administration & dosage Amitriptyline - therapeutic use Analgesics - administration & dosage Analgesics - therapeutic use Angiogenesis Animals Biomedical and Life Sciences Case Report Cat Diseases - drug therapy Cats Chronic infection Chronic pain Combined Modality Therapy - veterinary Drug therapy Female Gabapentin Gabapentin - administration & dosage Gabapentin - therapeutic use Glutamic acid receptors (ionotropic) Ketamine Ketamine - administration & dosage Ketamine - therapeutic use Life Sciences Male Medical treatment N-Methyl-D-aspartic acid receptors Neuralgia Neuralgia - drug therapy Neuralgia - etiology Neuralgia - veterinary Pain Pain perception Pain, Postoperative - drug therapy Pain, Postoperative - veterinary Plasma Gases - pharmacology Plasma Gases - therapeutic use Prednisone Prednisone - administration & dosage Prednisone - therapeutic use Quality of life Skin diseases Skin lesions Veterinary Medicine/Veterinary Science Zoology Feline medicine Non-thermal plasma Wound healing Dermatology Chronic pain
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Summary:	Cold atmospheric plasma (CAP) has been employed as a therapy against both acute and chronic skin lesions, contaminated or not, and has effects on angiogenesis and reepithelialization promoting healing. In this context, the present study aimed to evaluate the effects of a CAP jet associated with pharmacological treatment described by the 2015 AAHA/AAFP pain management guidelines and the 2022 WSAVA guidelines for the recognition, assessment, and treatment of pain, on the healing of chronic skin lesions caused by a pruritic reaction resulting from post-surgical neuropathic pain. To this end, a single CAP application was performed on a feline patient with a 6 months old recurrent contaminated cervical skin lesions along with administration of ketamine (10 µg/kg/min) following the prescription of prednisone (1 mg/kg, SID, 6 days), gabapentin (8 mg/kg, BID, 60 days) and amitriptyline (0.5 mg /kg, SID, 60 days). A single application of plasma associated with an NMDA antagonist, anti-inflammatory steroid, tricyclic antidepressant and gabapentinoid thus provided a significant improvement in the macroscopic appearance of the lesion within 10 days, and the owner reported the cessation of intense itching within the first four hours after treatment and a consequent improvement in the animal's quality of life. The medical treatment was finished almost a year since the writing of this paper, without clinical or reported recurrent signs of the condition. Therefore, we observed that single dose CAP application associated with ketamine, gabapentin, amitriptyline and prednisone leads to significant healing of chronically infected skin lesions resulting from post-surgical neuropathic pain.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Report-3 ObjectType-Case Study-4
ISSN:	0165-7380 1573-7446 1573-7446
DOI:	10.1007/s11259-024-10499-6