Search Results - "France, D S"

Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex by Lepourcelet, Maina, Chen, Ying-Nan P., France, Dennis S., Wang, Huisheng, Crews, Phillip, Petersen, Frank, Bruseo, Charles, Wood, Alexander W., Shivdasani, Ramesh A.

“…Key molecular lesions in colorectal and other cancers cause β-catenin-dependent transactivation of T cell factor (Tcf)-dependent genes. Disruption of this…”
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Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway by Kung, Andrew L, Zabludoff, Sonya D, France, Dennis S, Freedman, Steven J, Tanner, Elizabeth A, Vieira, Annelisa, Cornell-Kennon, Susan, Lee, Jennifer, Wang, Beqing, Wang, Jamin, Memmert, Klaus, Naegeli, Hans-Ulrich, Petersen, Frank, Eck, Michael J, Bair, Kenneth W, Wood, Alexander W, Livingston, David M

“…Homeostasis under hypoxic conditions is maintained through a coordinated transcriptional response mediated by the hypoxia-inducible factor (HIF) pathway and…”
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Structural basis for negative regulation of hypoxia-inducible factor-1α by CITED2 by Eck, Michael J, Freedman, Steven J, Sun, Zhen-Yu J, Kung, Andrew L, France, Dennis S, Wagner, Gerhard

“…Expression of hypoxia-responsive genes is mediated by the heterodimeric transcription factor hypoxia-inducible factor-1 (HIF-1) in complex with the…”
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Anatomical mapping of epidermal Langerhans cell densities in adults by Berman, B, Chen, V L, France, D S, Dotz, W I, Petroni, G

“…The densities of T6 antigen-bearing Langerhans cells in 112 biopsies of human skin from sixteen surgical out-patients and four cadavers were determined for…”
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Nonimmunochemical quantitation of mammalian apolipoprotein A-I in whole serum or plasma by nonreducing gel electrophoresis by France, D S, Hughes, T E, Miserendino, R, Spirito, J A, Babiak, J, Eskesen, J B, Tapparelli, C, Paterniti, Jr, J R

“…A rapid and convenient method for the quantitation of mammalian apoA-I has been developed. The method involves nonreducing sodium dodecyl sulfate gel…”
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Addition of short-contact anthralin therapy to an ultraviolet B phototherapy regimen: assessment of efficacy by Lebwohl, M, Berman, B, France, D S

“…The purpose of this study was to determine whether the addition of short-contact anthralin therapy to an ultraviolet B phototherapy regimen would result in…”
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Enhancement of limiting dilution in cloning mouse myeloma-spleen hybridomas by human low density lipoproteins by Mao, S J, France, D S

“…The limiting dilution technique is a critical step in the cloning of hybridomas for the preparation of monoclonal antibodies. We have found that culture medium…”
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Establishment of a Cell Line Retaining Langerhans Cell Characteristics by Berman, Brian, France, Dennis S.

“…A discontinuous gradient of polyethylene glycol (PEG) with dimethyl sulfoxide (DMSO) was used to induce fusion between guinea pig epidermal cells (GPEC)…”
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Quantitation of Cutaneous Langerhans Cells of Sarcoidosis Patients by Fox, Joshua L., Berman, Brian, Teirstein, Alvin S., France, Dennis S., Reed, Michael L.

“…Langerhans cells play a role in cell-mediated immune reactions which are often depressed in sarcoidosis. We examined the epidermis of 17 anergic patients with…”
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Production and use of an inhibitory monoclonal antibody to human lipoprotein lipase by Goldberg, I J, Paterniti, Jr, J R, France, D S, Martinelli, G, Cornicelli, J A

“…Studies were performed to produce a monoclonal antibody to human lipoprotein lipase, verify the specificity of the antibody for lipoprotein lipase, and use…”
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Halo giant congenital melanocytic nevus: in vitro immunologic studies by Berman, B, Shaieb, A M, France, D S, Altchek, D D

“…We have assessed in vitro humoral and cell-mediated immune reactions of a patient with a giant congenital melanocytic nevus that showed clinical and histologic…”
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De Novo Synthesis of Lysozyme by Human Epidermal Cells by Chen, Virginia L, France, Dennis S, Martinelli, Giorgio P

“…The presence of lysozyme in human epidermis was determined in extracts from the surface of human skin and in sonicates of human epidermal cell preparations…”
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Histochemical analysis of Langerhans' cells by Berman, B, France, D S

“…Single cell suspensions of epidermal cells from guinea pigs were analyzed histochemically for the presence of the following enzymes: 5'-adenosine…”
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Jumping into the 20th century before it is too late: is laboratory robotics still in its infancy? by Weinstein, D B, France, D S

“…Successful management of laboratory robotic automation programmes in the environment of research and drug discovery within the pharmaceutical industry may…”
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Total body irradiation and syngeneic marrow transplantation in a inbred rat model of acute myelogenous leukemia by Greenberger, J S, Lockwood, C J, France, D S, McGrath, T, Moloney, W C

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Biological evaluation of 1-alkyl-3-phenylthioureas as orally active HDL-elevating agents by Coppola, Gary M., Damon, Robert E., Eskesen, J. Bruce, France, Dennis S., Paterniti, James R.

“…A series of 1-alkyl-3-phenylthioureas were evaluated as HDL- and Apo A-I-elevating and triglyceride-lowering agents. Analogue 8d (HDL376) raises HDL…”
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1-Hydroxyalkyl-3-phenylthioureas as novel HDL-elevating agents by Coppola, Gary M., Damon, Robert E., Eskesen, J. Bruce, France, Dennis S., Paterniti, James R.

“…Thiourea 2 was identified as a potential HDL-elevating agent from a targeted database search. Structure–activity relationship of its analogs is described. A…”
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Thiourea-based gemfibrozil analogues as HDL-elevating agents by Coppola, Gary M, Damon, Robert E, Eskesen, J.Bruce, France, Dennis S, Paterniti, James R

“…A series of gemfibrozil analogues with a thiourea moiety embedded in the side chain was prepared and evaluated as HDL-elevating agents. Derivatives 8b, 9b, 9c,…”
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High level expression of human apolipoprotein A-I in transgenic rats raises total serum high density lipoprotein cholesterol and lowers rat apolipoprotein A-I by Swanson, M E, Hughes, T E, Denny, I S, France, D S, Paterniti, Jr, J R, Tapparelli, C, Gfeller, P, Bürki, K

“…To examine the consequences of increased apolipoprotein A-I production on cholesterol and lipoprotein metabolism, we have produced two lines of transgenic…”
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Oncology drug discovery applications using the FMAT 8100 HTS system by Lee, Jennifer Y, Miraglia, Sheri, Yan, Xiongwei, Swartzman, Elana, Cornell-Kennon, Susan, Mellentin-Michelotti, Julia, Bruseo, Charles, France, Dennis S

“…High-throughput screening (HTS) for potential anticancer agents requires a broad portfolio of assay platforms that may include kinase enzyme assays,…”
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