Search Results - "François, Boris"
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Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding
Published in Nucleic acids research (01-01-2005)“…The crystal structures of six complexes between aminoglycoside antibiotics (neamine, gentamicin C1A, kanamycin A, ribostamycin, lividomycin A and neomycin B)…”
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2
Crystal Structure of the Homo sapiens Cytoplasmic Ribosomal Decoding Site Complexed with Apramycin
Published in Angewandte Chemie International Edition (12-05-2006)“…On target: The crystal structure of the complex formed between apramycin and the cytoplasmic ribosomal decoding sites of human cells (see picture; complex in…”
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Crystal Structure of the Bacterial Ribosomal Decoding Site Complexed with a Synthetic Doubly Functionalized Paromomycin Derivative: a New Specific Binding Mode to an A-Minor Motif Enhances in vitro Antibacterial Activity
Published in ChemMedChem (12-11-2007)“…The crystal structure of the complex between oligonucleotide containing the bacterial ribosomal decoding site (A site) and the synthetic paromomycin analogue…”
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4
Binding of Neomycin-Class Aminoglycoside Antibiotics to Mutant Ribosomes with Alterations in the A Site of 16S rRNA
Published in Antimicrobial Agents and Chemotherapy (01-04-2006)“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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5
Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: A synergistic hydrophobic effect against resistant bacteria
Published in Bioorganic & medicinal chemistry letters (01-12-2010)“…Incorporation of an hydrophobic (phenethylamino)ethyl ether at C2″ of N1-(HABA)-3′,4′-dideoxyparomomycin led to a novel analog with an excellent antibacterial…”
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6
Antibacterial Aminoglycosides with a Modified Mode of Binding to the Ribosomal-RNA Decoding Site
Published in Angewandte Chemie International Edition (10-12-2004)“…A new twist of RNA fate: Site‐selective chemical functionalization at the C2′′OH group of paromomycin (1) afforded a novel analogue with potent inhibitory…”
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Crystal structure of the bacterial ribosomal decoding site complexed with amikacin containing the γ-amino-α-hydroxybutyryl (haba) group
Published in Biochimie (01-08-2006)“…Amikacin is the 4,6-linked aminoglycoside modified at position N1 of the 2-deoxystreptamine ring (ring II) by the L-haba group. In the present study, the…”
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Structure-Based Design, Synthesis, and A-Site rRNA Cocrystal Complexes of Functionally Novel Aminoglycoside Antibiotics: C2‘ ‘ Ether Analogues of Paromomycin
Published in Journal of medicinal chemistry (17-05-2007)“…A series of 2‘ ‘-O-substituted ether analogues of paromomycin were prepared based on new site-selective functionalizations. X-ray cocrystal complexes of…”
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9
Antibacterial Aminoglycosides with a Modified Mode of Binding to the Ribosomal-RNA Decoding Site
Published in Angewandte Chemie International Edition (20-04-2007)“…résumé non disponible…”
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10
Crystal Structure of the Homo sapiens Cytoplasmic Ribosomal Decoding Site Complexed with Apramycin
Published in Angewandte Chemie (12-05-2006)“…Mehr Verständnis: Die Kristallstruktur des Komplexes aus Apramycin und den zytoplasmatischen ribosomalen Dekodierungszentren menschlicher Zellen (siehe Bild;…”
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Crystallographic studies of Homo sapiens ribosomal decoding A site complexed with aminoglycosides
Published in Nucleic acids symposium series (2004) (2005)“…Aminoglycosides are highly effective antibacterial drugs that decrease translation accuracy by binding to the aminoacyl-tRNA decoding site (A site) of 16S…”
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12
Crystallographic studies of Homo sapiens ribosomal decoding A site complexed with aminoglycosides
Published in Nucleic Acids Symposium Series (2005)“…Aminoglycosides are highly effective antibacterial drugs that decrease translation accuracy by binding to the aminoacyl-tRNA decoding site (A site) of 16S…”
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13
Antibacterial Aminoglycosides with a Modified Mode of Binding to the Ribosomal‐RNA Decoding Site
Published in Angewandte Chemie (20-04-2007)Get full text
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14
Crystal Structure of the Homo sapiens Cytoplasmic Ribosomal Decoding Site Complexed with Apramycin
Published in Angewandte Chemie (12-05-2006)Get full text
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15
Antibacterial Aminoglycosides with a Modified Mode of Binding to the Ribosomal-RNA Decoding Site
Published in Angewandte Chemie (10-12-2004)“…Positionsselektive chemische Funktionalisierung der C2′′‐OH‐Gruppe von Paromomycin (1) lieferte ein Analogon, das mehrere Bakterienstämme, darunter einen…”
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16
Antibacterial Aminoglycosides with a Modified Mode of Binding to the Ribosomal-RNA Decoding Site
Published in Angewandte Chemie (20-04-2007)Get full text
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EXPERIMENTAL STUDIES OF INDUCED SUPERCONDUCTIVITY IN NORMAL METALS BY PROXIMITY EFFECT TUNNELING
Published 01-01-1979Get full text
Dissertation -
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EXPERIMENTAL STUDIES OF INDUCED SUPERCONDUCTIVITY IN NORMAL METALS BY PROXIMITY EFFECT TUNNELING
Published 1979Get full text
Dissertation