Search Results - "Franano, F Nicholas"

A Multi-center, Dose-escalation Study of Human type I Pancreatic Elastase (PRT-201) Administered after Arteriovenous Fistula Creation by Peden, Eric K., Leeser, David B., Dixon, Bradley S., El-Khatib, Mahmoud T., Roy-Chaudhury, Prabir, Lawson, Jeffrey H., Menard, Matthew T., Dember, Laura M., Glickman, Marc H., Gustafson, Pamela N., Blair, Andrew T., Magill, Marianne, Franano, F. Nicholas, Burke, Steven K.

“…Purpose To explore the safety and efficacy of PRT-201. Methods Randomized, double-blind, placebo-controlled, single-dose escalation study of PRT-201 (0.0033 to…”
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The ability of serum from alpha 1-antitrypsin-deficient patients to inhibit PRT-201, a recombinant human type I pancreatic elastase by Qamar, Amir A., Burke, Steven K., Lafleur, Jason D., Ding, Bee C., Bland, Kimberly S., Wong, Marco D., Gustafson, Pamela N., Blair, Andrew T., Franano, F. Nicholas

“…PRT‐201 is a recombinant human pancreatic elastase under development as a treatment for blood vessels to promote hemodialysis access patency. Proteases such as…”
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TCT-160 Effects of PRT-201, a Recombinant Human Type I Pancreatic Elastase, Treatment on the Elastin Content and Compliance of Atherosclerotic Tibial Arteries Using a Perfusion Myograph by Burke, Steven, Macdonald, Karen, Moss, Emma, Franano, F. Nicholas

“…Removing elastin fibers from an atherosclerotic artery could result in larger artery lumen diameter and greater blood flow…”
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Recombinant Human Elastase Alters the Compliance of Atherosclerotic Tibial Arteries After Ex Vivo Angioplasty by Burke, Steven K, Bingham, Karen, Moss, Emma, Gottlieb, Daniel P, Wong, Marco D, Bland, Kimberly S, Franano, F Nicholas

“…PURPOSE:This study was designed to determine whether vonapanitase (formerly PRT-201), a recombinant human elastase, treatment can fragment the protein elastin…”
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TCT-159 Effects of PRT-201, a Recombinant Human Type I Pancreatic Elastase, Treatment on the Elastin Content and Compliance of Atherosclerotic Tibial Arteries Following Ex Vivo Angioplasty by Burke, Steven, Moss, Emma, Macdonald, Karen, Wong, Marco, Gottlieb, Daniel, Bland, Kimberly, Franano, F. Nicholas

“…The purpose of this study was to investigate the use of PRT-201, a recombinant human type I pancreatic elastase, as an adjuvant therapy to balloon angioplasty…”
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Effects of Recombinant Human Type I Pancreatic Elastase on Human Atherosclerotic Arteries by Burke, Steven K, Macdonald, Karen, Moss, Emma, Bunton, David, Starcher, Barry, Wong, Marco D, Bland, Kimberly S, Franano, F Nicholas

“…RATIONALE:At physiologic pressures, elastic fibers constrain artery diameter. Local treatment of atherosclerotic arteries with PRT-201, a recombinant type I…”
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Application of Human Type I Pancreatic Elastase (PRT-201) to the venous Anastomosis of Arteriovenous Grafts in Patients with Chronic Kidney Disease by Dwivedi, Amit J., Roy-Chaudhury, Prabir, Peden, Eric K., Browne, Barry J., Ladenheim, Eric D., Scavo, Vincent A., Gustafson, Pamela N., Wong, Marco D., Magill, Marianne, Lindow, Francesca, Blair, Andrew T., Jaff, Michael R., Franano, F. Nicholas, Burke, Steven K.

“…Purpose To explore the safety and efficacy of PRT-201 applied to the outflow vein of a newly created arteriovenous graft (AVG). Methods Randomized,…”
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In Vitro Study of a Medical Device to Enhance Arteriovenous Fistula Eligibility and Maturation by Loree, Howard M, Agyapong, George, Favreau, Elyse G, Ngai, Gwendolyn A, Tansley, Geoff D, Dixon, Bradley S, Franano, F Nicholas

“…The arteriovenous fistula eligibility (AFE) system (Flow Forward Medical, Olathe, KS) is a small, temporary, wearable rotary blood pump system designed to…”
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Studies of human pancreatic elastase treatment of rabbit and human vein rings to predict human therapeutic doses by Burke, Steven K., Bunton, David, Bingham, Karen, Moss, Emma, Bland, Kimberly S., Starcher, Barry, Wong, Marco D., Franano, F. Nicholas

“…Vascular tissue contains abundant elastic fibers that contribute to vessel elasticity. Vonapanitase (formerly PRT‐201) is a recombinant human chymotrypsin‐like…”
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Data-Based Modelling of the Arteriovenous Fistula Eligibility (AFE) System for Wall Shear Stress Estimation by Golesorkhie, Farya, Barnes, Zachary, Yang, Fuwen, Loree, Howard M., Franano, F. Nicholas, Vlacic, Ljubo, Tansley, Geoff

“…The AFE System is a medical device intended to dilate the cephalic vein by increasing the blood flow and wall shear stress (WSS) in the vein over a period of…”
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Evidence of gadolinium dissociation from protein-DTPA-gadolinium complexes by Duncan, J R, Franano, F N, Edwards, W B, Welch, M J

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Tumor transport physiology: Implications for imaging and imaging-guided therapy by KUSZYK, Brian S, CORL, Frank M, FRANANO, F. Nicholas, BLUEMKE, David A, HOFMANN, Lawrence V, FORTMAN, Brian J, FISHMAN, Elliot K

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Metabolism of receptor targeted 111In-DTPA-glycoproteins: identification of 111In-DTPA-epsilon-lysine as the primary metabolic and excretory product by Franano, F N, Edwards, W B, Welch, M J, Duncan, J R

“…The hepatic and renal retention of indium-111 (111In) from 111In-labeled polypeptides has been the subject of many investigations. Because the lysosome is a…”
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Biodistribution and metabolism of targeted and nontargeted protein-chelate-gadolinium complexes: Evidence for gadolinium dissociation in vitro and in vivo by Franano, F.Nicholas, Edwards, W.Barry, Welch, Michael J., Brechbiel, Martin W., Gansow, Otto A., Duncan, James R.

“…The intracellular metabolism of receptor-targeted 153Gd-DTPA-glycoproteins was studied in vitro and in vivo. These agents bound to cell surface receptors,…”
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