Search Results - "François Meurens"

The pig as a medical model for acquired respiratory diseases and dysfunctions: An immunological perspective by Bertho, Nicolas, Meurens, François

“…•Swine lung immunology.•Swine as a medical model for Respiratory infections.•Swine as a medical model for Vaccination.•Swine as a medical model for Respiratory…”
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The immunology of the porcine skin and its value as a model for human skin by Summerfield, Artur, Meurens, François, Ricklin, Meret E.

“…•The porcine skin is a highly valuable pre-clinical model with many tools available.•Here we review the immune cells in the pig skin with a focus on dendritic…”
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The pig: a model for human infectious diseases by Meurens, François, Summerfield, Artur, Nauwynck, Hans, Saif, Linda, Gerdts, Volker

“…An animal model to study human infectious diseases should accurately reproduce the various aspects of disease. Domestic pigs ( Sus scrofa domesticus ) are…”
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Editorial: Rising stars in infectious agents and disease: 2021 by Meurens, François, Cloeckaert, Axel

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Research in non-rodent vertebrates enlightens the immunological landscape by Meurens, François, Bertho, Nicolas

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Flu RNA Vaccine: A Game Changer? by Meurens, François

“…Influenza virus infection is a major One Health concern worldwide [...]…”
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How Does cGAS Avoid Sensing Self-DNA under Normal Physiological Conditions? by Zheng, Wangli, Chen, Nanhua, Meurens, François, Zheng, Wanglong, Zhu, Jianzhong

“…cGAS is a cytosolic DNA sensor that activates innate immune responses by producing the second messenger 2′3′-cGAMP, which activates the adaptor STING. cGAS…”
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How the Innate Immune DNA Sensing cGAS-STING Pathway Is Involved in Autophagy by Zheng, Wanglong, Xia, Nengwen, Zhang, Jiajia, Chen, Nanhua, Meurens, François, Liu, Zongping, Zhu, Jianzhong

“…The cGAS-STING pathway is a key component of the innate immune system and exerts crucial roles in the detection of cytosolic DNA and invading pathogens…”
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The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKε by Luo, Jia, Zhang, Jiajia, Ni, Jinghua, Jiang, Sen, Xia, Nengwen, Guo, Yiwen, Shao, Qi, Cao, Qi, Zheng, Wanglong, Chen, Nanhua, Zhang, Quan, Chen, Hongjun, Chen, Qing, Zhu, Hongfei, Meurens, François, Zhu, Jianzhong

“…African swine fever virus (ASFV), a large and complex cytoplasmic double-stranded DNA virus, has developed multiple strategies to evade the antiviral innate…”
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The Porcine Cyclic GMP-AMP Synthase-STING Pathway Exerts an Unusual Antiviral Function Independent of Interferon and Autophagy by Jiang, Sen, Xia, Nengwen, Luo, Jia, Zhang, Youwen, Cao, Qi, Zhang, Jiajia, Wang, Yuening, Zhao, Yuan, Zheng, Wanglong, Chen, Nanhua, Meurens, François, Li, Xiangdong, Zhu, Jianzhong

“…The innate immune DNA-sensing cyclic GMP-AMP synthase (cGAS)-stimulator of interferon (IFN) gene (STING) pathway exerts strong antiviral activity through…”
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The Porcine and Chicken Innate DNA Sensing cGAS-STING-IRF Signaling Axes Exhibit Differential Species Specificity by Jiang, Sen, Luo, Jia, Zhang, Youwen, Cao, Qi, Wang, Yuening, Xia, Nengwen, Zheng, Wanglong, Chen, Nanhua, Meurens, François, Wu, Huiguang, Zhu, Jianzhong

“…Abstract The innate immune DNA sensing cyclic GMP-AMP synthase (cGAS)–stimulator of IFN genes (STING) signaling pathway plays a key role in host antiviral…”
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Saccharomyces cerevisiae modulates immune gene expressions and inhibits ETEC-mediated ERK1/2 and p38 signaling pathways in intestinal epithelial cells by Zanello, Galliano, Berri, Mustapha, Dupont, Joëlle, Sizaret, Pierre-Yves, D'Inca, Romain, Salmon, Henri, Meurens, François

“…Enterotoxigenic Escherichia coli (ETEC) infections result in large economic losses in the swine industry worldwide. ETEC infections cause pro-inflammatory…”
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Linoorbitides and enterolactone mitigate inflammation-induced oxidative stress and loss of intestinal epithelial barrier integrity by Almousa, Ahmed A., Meurens, François, Krol, Ed S., Alcorn, Jane

“…Barrier integrity dysfunction and oxidative stress are considered hallmarks of inflammatory bowel disease (IBD) pathogenesis. Their mitigation continues to be…”
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Comparative transcriptome analysis of TLR8 signaling cells revealed the porcine TLR8 specific differentially expressed genes by Ao, Da, Xia, Pengpeng, Jiang, Sen, Chen, Nanhua, Meurens, François, Zhu, Jianzhong

“…TLRs are the first discovered family of pattern recognition receptors (PRRs). They recognize pathogen associated molecular patterns (PAMPs) and initiate…”
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Humoral and cellular factors of maternal immunity in swine by Salmon, Henri, Berri, Mustapha, Gerdts, Volker, Meurens, François

“…Immunoglobulins cannot cross the placenta in pregnant sows. Neonatal pigs are therefore agammaglobulinemic at birth and, although immunocompetent, they cannot…”
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The signaling relations between three adaptors of porcine C-type lectin receptor pathway by Jiang, Sen, Ao, Da, Ni, Jinghua, Chen, Nanhua, Meurens, François, Zhu, Jianzhong

“…As one family of pattern recognition receptors (PRRs), The C-type lectin receptors (CLRs) play a key role in the anti-fungal infection. The CLR pathway…”
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African Swine Fever Virus Structural Protein p17 Inhibits Cell Proliferation through ER Stress-ROS Mediated Cell Cycle Arrest by Xia, Nengwen, Wang, Hui, Liu, Xueliang, Shao, Qi, Ao, Da, Xu, Yulin, Jiang, Sen, Luo, Jia, Zhang, Jiajia, Chen, Nanhua, Meurens, François, Zheng, Wanglong, Zhu, Jianzhong

“…African swine fever virus (ASFV) is a highly pathogenic large DNA virus that causes African swine fever (ASF) in domestic pigs and wild boars. The p17 protein,…”
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Animal board invited review: Risks of zoonotic disease emergence at the interface of wildlife and livestock systems by Meurens, François, Dunoyer, Charlotte, Fourichon, Christine, Gerdts, Volker, Haddad, Nadia, Kortekaas, Jeroen, Lewandowska, Marta, Monchatre-Leroy, Elodie, Summerfield, Artur, Wichgers Schreur, Paul J., van der Poel, Wim H.M., Zhu, Jianzhong

“…The ongoing coronavirus disease 19s pandemic has yet again demonstrated the importance of the human-animal interface in the emergence of zoonotic diseases, and…”
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African Swine Fever Virus A528R Inhibits TLR8 Mediated NF-κB Activity by Targeting p65 Activation and Nuclear Translocation by Liu, Xueliang, Ao, Da, Jiang, Sen, Xia, Nengwen, Xu, Yulin, Shao, Qi, Luo, Jia, Wang, Heng, Zheng, Wanglong, Chen, Nanhua, Meurens, François, Zhu, Jianzhong

“…African swine fever (ASF) is mainly an acute hemorrhagic disease which is highly contagious and lethal to domestic pigs and wild boars. The global pig industry…”
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Inter-relation analysis of signaling adaptors of porcine innate immune pathways by Ao, Da, Li, Shuangjie, Jiang, Sen, Luo, Jia, Chen, Nanhua, Meurens, François, Zhu, Jianzhong

“…•The six porcine signaling adaptors of TLR, RLR, NLR and CDR innate immune pathways were isolated, and characterized for cellular localization and signaling…”
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