Search Results - "Frame, I"

Purine import into malaria parasites as a target for antimalarial drug development by Frame, I. J., Deniskin, Roman, Arora, Avish, Akabas, Myles H.

“…Infection with Plasmodium species parasites causes malaria. Plasmodium parasites are purine auxotrophs. In all life cycle stages, they require purines for RNA…”
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Now is Our Opportunity to Revolutionise Cancer Clinical Trials by Bliss, J., Brown, J., Chalmers, A., Lemoine, N., Murphy, G., Wydenbach, K., Frame, I.

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Induction of the macrolide-resistance efflux pump Mega inhibits intoxication of Staphylococcus aureus strains by Streptococcus pneumoniae by Vidal, Ana G. Jop, Alibayov, Babek, Frame, I.J., Murin, Landon, Creel, Aidan, Hu, Dongping, Wu, Xueqing, Vidal, Jorge E.

“…Streptococcus pneumoniae (Spn) kills Staphylococcus aureus (Sau) through a contact-dependent mechanism that is catalyzed by cations, including iron, to convert…”
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Yeast-Based High-Throughput Screen Identifies Plasmodium falciparum Equilibrative Nucleoside Transporter 1 Inhibitors That Kill Malaria Parasites by Frame, I. J, Deniskin, Roman, Rinderspacher, Alison, Katz, Francine, Deng, Shi-Xian, Moir, Robyn D, Adjalley, Sophie H, Coburn-Flynn, Olivia, Fidock, David A, Willis, Ian M, Landry, Donald W, Akabas, Myles H

“…Equilibrative transporters are potential drug targets; however, most functional assays involve radioactive substrate uptake that is unsuitable for…”
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Identification via a Parallel Hit Progression Strategy of Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Plasmodium falciparum Parasite Proliferation by Sosa, Yvett, Deniskin, Roman, Frame, I. J, Steiginga, Matthew S, Bandyopadhyay, Deepak, Graybill, Todd L, Kallal, Lorena A, Ouellette, Michael T, Pope, Andrew J, Widdowson, Katherine L, Young, Robert J, Akabas, Myles H

“…Emerging resistance to current antimalarial medicines underscores the importance of identifying new drug targets and novel compounds. Malaria parasites are…”
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Targeting the Plasmodium vivax equilibrative nucleoside transporter 1 (PvENT1) for antimalarial drug development by Deniskin, Roman, Frame, I.J., Sosa, Yvett, Akabas, Myles H.

“…Infection with Plasmodium falciparum and vivax cause most cases of malaria. Emerging resistance to current antimalarial medications makes new drug development…”
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Transmembrane Segment 11 Appears to Line the Purine Permeation Pathway of the Plasmodium falciparum Equilibrative Nucleoside Transporter 1 (PfENT1) by Riegelhaupt, Paul M., Frame, I.J., Akabas, Myles H.

“…Purine transport is essential for malaria parasites to grow because they lack the enzymes necessary for de novo purine biosynthesis. The Plasmodium falciparum…”
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Malaria parasite type 4 equilibrative nucleoside transporters (ENT4) are purine transporters with distinct substrate specificity by Frame, I J, Merino, Emilio F, Schramm, Vern L, Cassera, María B, Akabas, Myles H

“…Malaria, caused by Plasmodia parasites, affects hundreds of millions of people. As purine auxotrophs, Plasmodia use transporters to import host purines for…”
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New tools to support collaboration and virtual organizations by Frame, I, Austen, K.F, Calleja, M, Dove, M.T, White, T.O.H, Wilson, D.J

“…Web resource…”
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Plasma biotin stability and impact on immunoassays in patients with renal dysfunction by Frame, I., Muthukumar, A.

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eScience for molecular-scale simulations and the eMinerals project by Salje, E.K.H, Artacho, E, Austen, K.F, Bruin, R.P, Calleja, M, Chappell, H.F, Chiang, G.-T, Dove, M.T, Frame, I, Goodwin, A.L, Kleese van Dam, K, Marmier, A, Parker, S.C, Pruneda, J.M, Todorov, I.T, Trachenko, K, Tyer, R.P, Walker, A.M, White, T.O.H

“…We review the work carried out within the…”
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Genetic Affinities of the Andaman Islanders, a Vanishing Human Population by Thangaraj, Kumarasamy, Singh, Lalji, Reddy, Alla G., Rao, V.Raghavendra, Sehgal, Subhash C., Underhill, Peter A., Pierson, Melanie, Frame, Ian G., Hagelberg, Erika

“…Background: The Andaman Islands in the Bay of Bengal are inhabited by hunter-gatherers of unknown origin, now on the verge of extinction. The Andamanese and…”
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Identifying the impact of diabetes research by Hanney, S. R., Home, P. D., Frame, I., Grant, J., Green, P., Buxton, M. J.

“…Aims  Assessment of the impact of health research is a growing but problematic field. We examined how a combination of approaches might together inform…”
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Genetic exchange as a possible source of genomic diversity in sylvatic populations of Trypanosoma cruzi by Carrasco, H J, Frame, I A, Valente, S A, Miles, M A

“…Thirty six stocks of Trypanosoma cruzi isolated from sylvatic mammals (32 Didelphis marsupialis and one Philander opossum) and triatomine bugs (Rhodnius…”
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Genetic Diversity and Genetic Exchange in Trypanosoma cruzi: Dual Drug-resistant "Progeny" from Episomal Transformants by Stothard, J, Frame, I, Miles, M

“…Extensive characterisation of Trypanosoma cruzi by isoenzyme phenotypes has separated the species into three principal zymodeme groups, Z1, Z2 and Z3, and into…”
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Analysis of Genetic Diversity of Trypanosoma cruzi: an Application of Riboprinting and Gradient Gel Electrophoresis Methods by Stothard, J R, Frame, I A, Carrasco, H J, Miles, M A

“…Analysis of restriction fragment length polymorphism (RFLP) profiles derived from digestion of polymerase chain reaction (PCR) products of the ribosomal 18S…”
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Use of polymerase chain reaction-based single strand conformational polymorphism and denaturing gradient gel electrophoresis methods for detection of sequence variation of ribosomal DNA of Trypanosoma cruzi by Stothard, J.R., Frame, I.A., Miles, M.A.

“…Polymerase chain reaction (PCR) was used to amplify the V1 region of the small sub-unit (18S) ribosomal DNA gene from representative strains of Trypanosoma…”
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On the molecular taxonomy of Trypanosoma cruzi using riboprinting by Stothard, J R, Frame, I A, Carrasco, H J, Miles, M A

“…In order to investigate the molecular taxonomy within Trypanosoma cruzi, the ribosomal small subunit (18S) gene was amplified by polymerase chain reaction…”
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Temperature gradient gel electrophoresis (TGGE) analysis of riboprints from Trypanosoma cruzi by Stothard, J R, Frame, I A, Carrasco, H J, Miles, M A

“…To test the homogeneity of 18S sequences within Trypanosoma cruzi, riboprint profiles were separated by temperature gradient gel electrophoresis (TGGE). Upon…”
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New BEL-like LTR-retrotransposons in Fugu rubripes, Caenorhabditis elegans, and Drosophila melanogaster by Frame, I G, Cutfield, J F, Poulter, R T

“…The BEL group of retroelements is present in greater numbers, variety and taxonomic range than may have been thought previously. In addition to the insects,…”
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