Search Results - "Fram, R. J."

Phase I study of the orally administered butyrate prodrug, tributyrin, in patients with solid tumors by CONLEY, B. A, EGORIN, M. J, TAIT, N, ROSEN, D. M, SAUSVILLE, E. A, DOVER, G, FRAM, R. J, VAN ECHO, D. A

“…Butyrates have been studied as cancer differentiation agents in vitro and as a treatment for hemoglobinopathies. Tributyrin, a triglyceride with butyrate…”
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Intravenous pamidronate disodium treatment of bone metastases in patients with breast cancer. A dose-seeking study by Glover, D, Lipton, A, Keller, A, Miller, A A, Browning, S, Fram, R J, George, S, Zelenakas, K, Macerata, R S, Seaman, J J

“…Treatment of the symptoms of bone metastases currently involves the use of narcotic medication, radiation therapy, or hormonal therapy. Pamidronate disodium, a…”
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Characterization of acquired resistance to cis-diamminedichloroplatinum(II) in BE human colon carcinoma cells by FRAM, R. J, WODA, B. A, WILSON, J. M, ROBICHAUD, N

“…To study mechanisms underlying resistance to cis-diamminedichloroplatinum (II) (cis-DDP) we have induced resistance to this agent in BE human colon carcinoma…”
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Mismatch repair of cis-diamminedichloroplatinum(II)-induced DNA damage by Fram, R J, Cusick, P S, Wilson, J M, Marinus, M G

“…Because cytotoxicity by an alkylating agent such as N-methyl-N'-nitrosoguanidine is markedly increased in adenine methylase-deficient dam-3 Escherichia coli,…”
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Preirradiation chemotherapy of supratentorial malignant primary brain tumors with intracarotid cis-platinum (CDDP) and i.v. BCNU. A phase II trial by Recht, L, Fram, R J, Strauss, G, Fitzgerald, T J, Liepman, M, Lew, R, Kadish, S, Sherman, D, Wilson, J, Greenberger, J

“…Thirty patients with histologically verified malignant supratentorial gliomas were treated with a preirradiation chemotherapy protocol consisting of two…”
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Lethal effects of 1-beta-D-arabinofuranosylcytosine incorporation into deoxyribonucleic acid during ultraviolet repair by Kufe, D W, Weichselbaum, R, Egan, E M, Dahlberg, W, Fram, R J

“…We have previously demonstrated that 1-beta-D-arabinofuranosylcytosine (ara-C) incorporates into leukemic cell DNA and that the extent of this incorporation…”
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Inhibition of DNA excision repair and the repair of X-ray-induced DNA damage by cytosine arabinoside and hydroxyurea by Fram, R J, Kufe, D W

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Schedule dependence of buthionine sulfoximine in reversing resistance to cisplatin by Robichaud, N J, Fram, R J

“…We have found that the potentiation of antiproliferative effects by buthionine sulfoximine (BSO) of cell growth inhibition induced by cisplatin are highly…”
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Sequence specificity of streptozotocin-induced mutations by MACK, S. L, FRAM, R. J, MARINUS, M. G

“…The isolation and characterization of streptozotocin (STZ)-induced mutations in the phage P22 mnt repressor gene is described. Cells carrying the plasmid-borne…”
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Effect of 1-beta-D-arabinofuranosyl cytosine and hydroxyurea on the repair of X-ray-induced DNA single-strand breaks in human leukemic blasts by Fram, R J, Kufe, D W

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Subasumstat, a first-in-class inhibitor of SUMO-activating enzyme, demonstrates dose-dependent target engagement and SUMOylation inhibition, leading to rapid activation of innate and adaptive immune responses in the dose escalation portion of a phase 1/2 clinical study by Saggu, G., Stroopinsky, D., Dudek, A.Z., Olszanski, A.J., Juric, D., Dowlati, A., Vaishampayan, U., Assad, H., Rodón, J., Gibbs, J., Green, J., Du, Z., Rudicell, R., Kannan, K., Gharavi, R., Gomez-Pinillos, A., Fram, R.J., Berger, A., Sachsenmeier, K., Kasar, S.

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Cisplatin and platinum analogues: recent advances by Fram, Robert j

“…Cisplatin is a critically important antineoplastic agent employed in treating patients who have a broad spectrum of neoplasms. Resistance to this agent poses a…”
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Potentiation of ara-C induced cytotoxicity by hydroxyurea in LoVo colon carcinoma cells by Robichaud, N J, Fram, R J

“…The present study was undertaken to determine whether cytotoxicity by 1-beta-D-arabinofuranosylcytosine (ara-C) in LoVo colon carcinoma cells, which are…”
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Gene expression caused by alkylating agents and cis-diamminedichloroplatinum(II) in Escherichia coli by FRAM, R. J, CROCKETT, J, VOLKERT, M. R

“…Previous work has demonstrated heterogeneous effects of methylating agents on induction of DNA damage inducible genes in Escherichia coli. These studies…”
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Bone metastases by Hamdalla, H, Fram, R J

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Studies on mutagenesis and repair induced by platinum analogs by Fram, R J, Cusick, P S, Marinus, M G

“…Mutagenesis and cytotoxicity were studied in Escherichia coli by iproplatin and carboplatin, two analogs of cisplatin (CDDP) currently undergoing clinical…”
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Accumulation of leukemic cell DNA strand breaks with adriamycin and cytosine arabinoside by Fram, R J, Egan, E M, Kufe, D W

“…Adriamycin (doxorubicin) and cytosine arabinoside (Ara-C) induce single strand DNA breaks and DNA fragmentation. In view of the therapeutic efficacy of…”
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Gene expression in E. coli after treatment with streptozotocin by Fram, R J, Marinus, M G, Volkert, M R

“…Gene induction by the methylating agents streptozotocin (STZ), N-methyl-N-nitrosourea (MNU), and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was evaluated in…”
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DNA strand breaks caused by inhibitors of DNA synthesis: 1-beta-D-arabinofuranosylcytosine and aphidicolin by Fram, R J, Kufe, D W

“…We have used alkaline elution analysis to determine whether strand breaks are detectable in L1210 DNA labeled during and prior to…”
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Genetic Control of Ligand-Induced Events in B Lymphocytes by Fram, Robert J, Sidman, Charles L, Unanue, Emil R

“…The early cycle of events which follows the binding of anti-Ig ligands to the surface Ig molecules of B lymphocytes was compared in several inbred strains of…”
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