Search Results - "Frakes, Ashley"

The UPRER: Sensor and Coordinator of Organismal Homeostasis by Frakes, Ashley E., Dillin, Andrew

“…Life is stressful. Organisms are repeatedly exposed to stressors that disrupt protein homeostasis (proteostasis), resulting in protein misfolding and…”
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Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis by Frakes, Ashley E., Ferraiuolo, Laura, Haidet-Phillips, Amanda M., Schmelzer, Leah, Braun, Lyndsey, Miranda, Carlos J., Ladner, Katherine J., Bevan, Adam K., Foust, Kevin D., Godbout, Jonathan P., Popovich, Phillip G., Guttridge, Denis C., Kaspar, Brian K.

“…Neuroinflammation is one of the most striking hallmarks of amyotrophic lateral sclerosis (ALS). Nuclear factor-kappa B (NF-κB), a master regulator of…”
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Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans by Frakes, Ashley E, Metcalf, Melissa G, Tronnes, Sarah U, Bar-Ziv, Raz, Durieux, Jenni, Gildea, Holly K, Kandahari, Nazineen, Monshietehadi, Samira, Dillin, Andrew

“…The ability of the nervous system to sense cellular stress and coordinate protein homeostasis is essential for organismal health. Unfortunately, stress…”
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Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis by Song, SungWon, Miranda, Carlos J, Braun, Lyndsey, Meyer, Kathrin, Frakes, Ashley E, Ferraiuolo, Laura, Likhite, Shibi, Bevan, Adam K, Foust, Kevin D, McConnell, Michael J, Walker, Christopher M, Kaspar, Brian K

“…Expression of MHC class I molecules on motor neurons protects them from astrocyte-induced toxicity in ALS. Astrocytes isolated from individuals with…”
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Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism by Ferraiuolo, Laura, Meyer, Kathrin, Sherwood, Thomas W., Vick, Jonathan, Likhite, Shibi, Frakes, Ashley, Miranda, Carlos J., Braun, Lyndsey, Heath, Paul R., Pineda, Ricardo, Beattie, Christine E., Shaw, Pamela J., Askwith, Candice C., McTigue, Dana, Kaspar, Brian K.

“…Oligodendrocytes have recently been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS). Here we show that, in vitro, mutant superoxide…”
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Astrocytes from familial and sporadic ALS patients are toxic to motor neurons by Kaspar, Brian K, Haidet-Phillips, Amanda M, Hester, Mark E, Miranda, Carlos J, Meyer, Kathrin, Braun, Lyndsey, Frakes, Ashley, Song, SungWon, Likhite, Shibi, Murtha, Matthew J, Foust, Kevin D, Rao, Meghan, Eagle, Amy, Kammesheidt, Anja, Christensen, Ashley, Mendell, Jerry R, Burghes, Arthur H M

“…Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease, with astrocytes implicated as contributing substantially to motor neuron death in familial…”
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The UPR ER : Sensor and Coordinator of Organismal Homeostasis by Frakes, Ashley E, Dillin, Andrew

“…Life is stressful. Organisms are repeatedly exposed to stressors that disrupt protein homeostasis (proteostasis), resulting in protein misfolding and…”
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An NF-κB - EphrinA5-Dependent Communication between NG2+ Interstitial Cells and Myoblasts Promotes Muscle Growth in Neonates by Gu, Jin-Mo, Wang, David J., Peterson, Jennifer M., Shintaku, Jonathan, Liyanarachchi, Sandya, Coppola, Vincenzo, Frakes, Ashley E., Kaspar, Brian K., Cornelison, Dawn D., Guttridge, Denis C.

“…Skeletal muscle growth immediately following birth is critical for proper body posture and locomotion. However, compared with embryogenesis and adulthood, the…”
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ER Unfolded Protein Response in Liver In Vivo Is Characterized by Reduced, Not Increased, De Novo Lipogenesis and Cholesterol Synthesis Rates with Uptake of Fatty Acids from Adipose Tissue: Integrated Gene Expression, Translation Rates and Metabolic Fluxes by Ward, Catherine P, Peng, Lucy, Yuen, Samuel, Chang, Michael, Karapetyan, Rozalina, Nyangau, Edna, Mohammed, Hussein, Palacios, Hector, Ziari, Naveed, Joe, Larry K, Frakes, Ashley E, Dandan, Mohamad, Dillin, Andrew, Hellerstein, Marc K

“…The unfolded protein response in the endoplasmic reticulum (UPR ) is involved in a number of metabolic diseases. Here, we characterize UPR -induced metabolic…”
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Aging alters the metabolic flux signature of the ER‐unfolded protein response in vivo in mice by Ward, Catherine P., Peng, Lucy, Yuen, Samuel, Halstead, John, Palacios, Hector, Nyangau, Edna, Mohammed, Hussein, Ziari, Naveed, Dandan, Mohamad, Frakes, Ashley E., Gildea, Holly K., Dillin, Andrew, Hellerstein, Marc K.

“…Age is a risk factor for numerous diseases, including neurodegenerative diseases, cancers, and diabetes. Loss of protein homeostasis is a central hallmark of…”
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Measurements of Physiological Stress Responses in C. Elegans by Bar-Ziv, Raz, Frakes, Ashley E, Higuchi-Sanabria, Ryo, Bolas, Theodore, Frankino, Phillip A, Gildea, Holly K, Metcalf, Melissa G, Dillin, Andrew

“…Organisms are often exposed to fluctuating environments and changes in intracellular homeostasis, which can have detrimental effects on their proteome and…”
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Cell non-autonomous control of autophagy and metabolism by glial cells by Metcalf, Melissa G., Monshietehadi, Samira, Sahay, Arushi, Durieux, Jenni, Frakes, Ashley E., Velichkovska, Martina, Mena, Cesar, Farinas, Amelia, Sanchez, Melissa, Dillin, Andrew

“…Glia are the protectors of the nervous system, providing neurons with support and protection from cytotoxic insults. We previously discovered that four…”
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rAAV Gene Therapy in a Canavan's Disease Mouse Model Reveals Immune Impairments and an Extended Pathology Beyond the Central Nervous System by Ahmed, Seemin Seher, Schattgen, Stefan A, Frakes, Ashley E, Sikoglu, Elif M, Su, Qin, Li, Jia, Hampton, Thomas G, Denninger, Andrew R, Kirschner, Daniel A, Kaspar, Brian, Matalon, Reuben, Gao, Guangping

“…Aspartoacylase (AspA) gene mutations cause the pediatric lethal neurodegenerative Canavan disease (CD). There is emerging promise of successful gene therapy…”
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Glia of C. elegans coordinate a protective organismal heat shock response independent of the neuronal thermosensory circuit by Gildea, Holly K, Frankino, Phillip A, Tronnes, Sarah U, Pender, Corinne L, Durieux, Jenni, Dishart, Julian G, Choi, Hyun Ok, Hunter, Tayla D, Cheung, Shannon S, Frakes, Ashley E, Sukarto, Edward, Wickham, Kevin, Dillin, Andrew

“…Aging organisms lose the ability to induce stress responses, becoming vulnerable to protein toxicity and tissue damage. Neurons can signal to peripheral…”
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Additive amelioration of ALS by co‐targeting independent pathogenic mechanisms by Frakes, Ashley E., Braun, Lyndsey, Ferraiuolo, Laura, Guttridge, Denis C., Kaspar, Brian K.

“…Objective Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which glia are central mediators of motor neuron (MN) death. Since…”
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Neural Stem Cells as a Therapeutic Approach for Amyotrophic Lateral Sclerosis by Ferraiuolo, Laura, Frakes, Ashley, Kaspar, Brian K

“…Proliferating neural stem cells (NSCs) were first identified in the late 1960s in the adult rat brain[1] as multipotent self-renewing stem cells, able to…”
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MHC class I protects motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis (ALS) by Song, SungWon, Miranda, Carlos J., Braun, Lyndsey, Meyer, Kathrin, Frakes, Ashley E., Ferraiuolo, Laura, Likhite, Shibi, Bevan, Adam K., Foust, Kevin D., McConnell, Michael J., Walker, Christopher M., Kaspar, Brian K.

“…Astrocytes isolated from individuals with amyotrophic lateral sclerosis (ALS) are toxic towards motor neurons (MNs) and play a non-cell autonomous role in…”
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Disease progression in a mouse model of amyotrophic lateral sclerosis: the influence of chronic stress and corticosterone by Fidler, Jonathan A., Treleaven, Christopher M., Frakes, Ashley, Tamsett, Thomas J., McCrate, Mary, Cheng, Seng H., Shihabuddin, Lamya S., Kaspar, Brian K., Dodge, James C.

“…ABSTRACT Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by motor neuron cell loss, muscular atrophy, and a…”
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Microglia Induce Motor Neuron Death via the Classical NF-[kappa]B Pathway in Amyotrophic Lateral Sclerosis by Frakes, Ashley E, Ferraiuolo, Laura, Haidet-Phillips, Amanda M, Schmelzer, Leah, Braun, Lyndsey, Miranda, Carlos J, Ladner, Katherine J, Bevan, Adam K, Foust, Kevin D, Godbout, Jonathan P, Popovich, Phillip G, Guttridge, Denis C, Kaspar, Brian K

“…Neuroinflammation is one of the most striking hallmarks of amyotrophic lateral sclerosis (ALS). Nuclear factor-kappa B (NF-κB), a master regulator of…”
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The Role of Neuroinflammation in the Pathogenesis of Amyotrophic Lateral Sclerosis by Frakes, Ashley E

“…Amyotrophic lateral sclerosis (ALS), or Lou Gehrigs disease, is a fatal neurodegenerative disease affecting motor neurons resulting in severe muscle atrophy,…”
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