Search Results - "Fraker, P J"

Zinc pyrithione induces apoptosis and increases expression of Bim by Mann, J J, Fraker, P J

“…We demonstrate herein that zinc pyrithione can induce apoptosis at nanomolar concentrations. Zinc pyrithione was a potent inducer of cell death causing greater…”
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The dynamic link between the integrity of the immune system and zinc status by Fraker, P J, King, L E, Laakko, T, Vollmer, T L

“…The results of more than three decades of work indicate that zinc deficiency rapidly diminishes antibody- and cell-mediated responses in both humans and…”
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Apoptosis plays a distinct role in the loss of precursor lymphocytes during zinc deficiency in mice by King, L E, Osati-Ashtiani, F, Fraker, P J

“…Lymphopenia is a characteristic of zinc deficiency, which is associated with massive loss of pre-B and pre-T cells from the primary lymphoid organs of…”
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A reappraisal of the role of zinc in life and death decisions of cells by Fraker, P J, Telford, W G

“…There is a great deal of interest in chemicals and biochemicals that can modulate apoptosis. As will be discussed, zinc, an essential trace element, can induce…”
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Zinc: Health Effects and Research Priorities for the 1990s by Walsh, Carol T., Sandstead, Harold H., Prasad, Ananda S., Newberne, Paul M., Fraker, Pamela J.

“…This review critically summarizes the literature on the spectrum of health effects of zinc status, ranging from symptoms of zinc deficiency to excess exposure…”
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Variations in the Cell Cycle Status of Lymphopoietic and Myelopoietic Cells Created by Zinc Deficiency by King, L. E., Fraker, P. J.

“…Zinc deficiency causes thymic atrophy and lymphopenia. It was recently shown that zinc deficiency causes sizable losses among the precursor lymphocytes, such…”
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A distinct role for apoptosis in the changes in lymphopoiesis and myelopoiesis created by deficiencies in zinc by Fraker, P J, King, L E

“…Reduced numbers of lymphocytes in the peripheral immune system appeared to be a significant cause of the loss in host defense capacity in humans and animals…”
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Rapid quantitation of apoptosis in pure and heterogeneous cell populations using flow cytometry by Telford, W G, King, L E, Fraker, P J

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Evaluation of glucocorticoid-induced DNA fragmentation in mouse thymocytes by flow cytometry by Telford, W G, King, L E, Fraker, P J

“…The ability of glucocorticoids to induce apoptosis or programmed cell death in mouse thymocytes is well-established. Measurement of apoptosis-associated…”
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Chronic elevation of plasma corticosterone causes reductions in the number of cycling cells of the B lineage in murine bone marrow and induces apoptosis by GARVY, B. A, KING, L. E, TELFORD, W. G, MORFORD, L. A, FRAKER, P. J

“…Steroid-containing implants were used to ascertain the effects of chronic elevation of physiological levels of plasma corticosterone (CS) (30-100…”
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Glucocorticoids and irradiation-induced apoptosis in normal murine bone marrow B-lineage lymphocytes as determined by flow cytometry by GARVY, B. A, TELFORD, W. G, KING, L. E, FRAKER, P. J

“…A substantial proportion of murine bone marrow B220+ and IgM+ cells were induced to undergo apoptosis when exposed to glucocorticoids or ionizing radiation in…”
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Variance in the resistance of murine early bone marrow B cells to a deficiency in zinc by Osati-Ashtiani, F, King, L E, Fraker, P J

“…Little is known of the effects of nutritional deficiencies on lymphopoietic processes. Nevertheless, deficiencies in zinc adversely affect imm_une function…”
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Zinc requirement for macrophage function: effect of zinc deficiency on uptake and killing of a protozoan parasite by WIRTH, J. J, FRAKER, P. J, KIERSZENBAUM, F

“…The effects of suboptimal levels of zinc, an essential trace element, on the ability of murine macrophages to associate with and destroy a pathogenic parasite,…”
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Depletion of cells of the B lineage in the bone marrow of zinc-deficient mice by King, L E, Osati-Ashtiani, F, Fraker, P J

“…Though lymphopenia is often noted in malnourished humans and rodents, little is known about the effects of suboptimal nutriture on lymphopoietic processes…”
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The many roles of apoptosis in immunity as modified by aging and nutritional status by Fraker, P J, Lill-Elghanian, D A

“…Apoptosis plays a vital role in the elimination of anti-self clones, down regulation of immune responses and the killing of virally infected and malignant…”
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Functional capacity of the residual lymphocytes from zinc-deficient adult mice by Cook-Mills, Joan M., Fraker, Pamela J.

“…Zn deficiency has been shown to reduce host defence drastically. It was of interest to determine the capacity of the residual lymphocytes from Zn-deficient…”
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Suppression of the antigenic response of murine bone marrow B cells by physiological concentrations of glucocorticoids by GARVY, B. A, FRAKER, P. J

“…Data presented here indicate that the immature B cells of murine bone marrow (BM) may be as sensitive to glucocorticoids (GC) as are immature thymocytes, since…”
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Flow cytometric analysis of the phenotypic distribution of splenic lymphocytes in zinc-deficient adult mice by King, L E, Fraker, P J

“…Many immunodeficiency states create an imbalance in the ratio of T cells to B cells or in the subsets of lymphocytes found within these two major classes. A…”
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The response of pulmonary vascular endothelial cells to monocrotaline pyrrole: cell proliferation and DNA synthesis in vitro and in vivo by Lappin, P.B. (Michigan State University, East Lansing.), Ross, K.L, King, L.E, Fraker, P.J, Roth, R.A

“…Monocrotaline pyrrole (MCTP) causes pulmonary vascular endothelial cell (EC) injury followed by progressive pulmonary vascular leak in vivo and the inhibition…”
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Optimization of peroxide production by resident macrophages by Cook-Mills, J M, Fraker, P J

“…Previous reports indicated that resident macrophages produced low or nondetectable quantities of H2O2 (1-10 nmol H2O2/mg resident macrophage protein) when…”
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