Search Results - "Fragoulis, Emmanuel G."

L-DOPA decarboxylase mRNA expression is associated with tumor stage and size in head and neck squamous cell carcinoma: a retrospective cohort study by Geomela, Panagiota-Aikaterini, Kontos, Christos K, Yiotakis, Ioannis, Fragoulis, Emmanuel G, Scorilas, Andreas

“…Head and neck squamous cell carcinoma (HNSCC) represents one of the most commonly diagnosed malignancies worldwide. The DDC gene encodes L-DOPA decarboxylase,…”
Get full text

Uncovering the clinical utility of miR-143, miR-145 and miR-224 for predicting the survival of bladder cancer patients following treatment by Avgeris, Margaritis, Mavridis, Konstantinos, Tokas, Theodoros, Stravodimos, Konstantinos, Fragoulis, Emmanuel G, Scorilas, Andreas

“…Accurate prognosis is a key factor in establishing optimal therapeutic decisions; yet in the case of bladder cancer (BlCa) current prognostic indicators cannot…”
Get full text

Decreased expression of microRNAs targeting type-2 diabetes susceptibility genes in peripheral blood of patients and predisposed individuals by Kokkinopoulou, Ioanna, Maratou, Eirini, Mitrou, Panayota, Boutati, Eleni, Sideris, Diamantis C., Fragoulis, Emmanuel G., Christodoulou, Maria-Ioanna

“…Aim Certain microRNA molecules (miRNAs) that target genes involved in beta-cell growth and insulin resistance are found deregulated in patients with type-2…”
Get full text

Blood-based analysis of 84 microRNAs identifies molecules deregulated in individuals with type-2 diabetes, risk factors for the disease or metabolic syndrome by Avgeris, Margaritis, Kokkinopoulou, Ioanna, Maratou, Eirini, Mitrou, Panayota, Boutati, Eleni, Scorilas, Andreas, Fragoulis, Emmanuel G., Christodoulou, Maria-Ioanna

“…Micro-RNAs (miRNAs) are implicated in insulin-signaling and the development of type-2 diabetes (T2D). Their deregulated expression is mostly described in the…”
Get full text

Clinical evaluation of microRNA-145 expression in renal cell carcinoma: a promising molecular marker for discriminating and staging the clear cell histological subtype by Papadopoulos, Emmanuel I, Petraki, Constantina, Gregorakis, Alkiviadis, Fragoulis, Emmanuel G, Scorilas, Andreas

“…The vast majority of malignancies detected in renal parenchyma are diagnosed as renal cell carcinoma (RCC), whose subtype discrimination and determination of…”
Get more information

Blood-based analysis of type-2 diabetes mellitus susceptibility genes identifies specific transcript variants with deregulated expression and association with disease risk by Christodoulou, Maria-Ioanna, Avgeris, Margaritis, Kokkinopoulou, Ioanna, Maratou, Eirini, Mitrou, Panayota, Kontos, Christos K., Pappas, Efthimios, Boutati, Eleni, Scorilas, Andreas, Fragoulis, Emmanuel G.

“…Despite significant progress by genome-wide association studies, the ability of genetic variants to conduce to the prediction or prognosis of type-2 diabetes…”
Get full text

Human l-DOPA decarboxylase mRNA is a target of miR-145: A prediction to validation workflow by Papadopoulos, Emmanuel I., Fragoulis, Emmanuel G., Scorilas, Andreas

“…l-DOPA decarboxylase (DDC) is a multiply-regulated gene which encodes the enzyme that catalyzes the biosynthesis of dopamine in humans. MicroRNAs comprise a…”
Get full text

L-DOPA decarboxylase mRNA levels provide high diagnostic accuracy and discrimination between clear cell and non-clear cell subtypes in renal cell carcinoma by Papadopoulos, Emmanuel I., Petraki, Constantina, Gregorakis, Alkiviadis, Chra, Eleni, Fragoulis, Emmanuel G., Scorilas, Andreas

“…Renal cell carcinoma (RCC) is the most frequent type of kidney cancer. RCC patients frequently present with arterial hypertension due to various causes,…”
Get full text

Release of Membrane-Associated L-Dopa Decarboxylase from Human Cells by Chalatsa, Ioanna, Fragoulis, Emmanuel G., Vassilacopoulou, Dido

“…L-Dopa Decarboxylase is a pyridoxal 5-phosphate (PLP)-dependent enzyme that catalyses the decarboxylation of L-Dopa to dopamine. In this study, we investigated…”
Get full text

Essential cysteine residues for human RNase [kappa] catalytic activity by Kiritsi, Marianna N, Fragoulis, Emmanuel G, Sideris, Diamantis C

“…Human RNase [kappa] is an endoribonuclease expressed in almost all tissues and organs and belongs to a highly conserved protein family bearing representatives…”
Get full text

Essential cysteine residues for human RNase κ catalytic activity by Kiritsi, Marianna N., Fragoulis, Emmanuel G., Sideris, Diamantis C.

“…Human RNase κ is an endoribonuclease expressed in almost all tissues and organs and belongs to a highly conserved protein family bearing representatives in all…”
Get full text

l-Dopa decarboxylase (DDC) constitutes an emerging biomarker in predicting patients’ survival with stomach adenocarcinomas by Florou, Dimitra, Papadopoulos, Iordanis N., Fragoulis, Emmanuel G., Scorilas, Andreas

“…Purpose Stomach adenocarcinoma represents a major health problem and is regarded as the second commonest cause of cancer-associated mortality, universally,…”
Get full text

Expression analysis and clinical utility of L-Dopa decarboxylase (DDC) in prostate cancer by Avgeris, Margaritis, Koutalellis, Georgios, Fragoulis, Emmanuel G., Scorilas, Andreas

“…L-Dopa decarboxylase (DDC) is a pyridoxal 5′-phosphate-dependent enzyme that was found to be involved in many malignancies. The aim of this study was to…”
Get full text

Expression of enzymatically active L-DOPA decarboxylase in human peripheral leukocytes by Kokkinou, Ioanna, Nikolouzou, Eleftheria, Hatzimanolis, Alexandros, Fragoulis, Emmanuel G., Vassilacopoulou, Dido

“…L-DOPA decarboxylase (DDC) is a pyridoxal 5-phosphate (PLP)-dependent enzyme that catalyses the decarboxylation of L-DOPA to dopamine. Dopamine (DA) has been…”
Get full text

l -DOPA Decarboxylase ( DDC ) Expression Status as a Novel Molecular Tumor Marker for Diagnostic and Prognostic Purposes in Laryngeal Cancer by Patsis, Christos, Glyka, Vasiliki, Yiotakis, Ioannis, Fragoulis, Emmanuel G, Scorilas, Andreas

“…l -DOPA decarboxylase (DDC) plays an essential role in the enzymatic synthesis of dopamine and alterations in its gene expression have been reported in several…”
Get full text

Detection, Purification and Identification of An Endogenous Inhibitor of l-Dopa Decarboxylase Activity from Human Placenta by Vassiliou, Alice-Georgia, Fragoulis, Emmanuel G., Vassilacopoulou, Dido

“…An endogenous inhibitor of l -Dopa decarboxylase activity was identified and purified from human placenta. The endogenous inhibitor of l -Dopa decarboxylase…”
Get full text

The U937 macrophage cell line expresses enzymatically active l -Dopa decarboxylase by Kokkinou, Ioanna, Fragoulis, Emmanuel G, Vassilacopoulou, Dido

“…Abstract In the present study we demonstrate that enzymatically active l -Dopa decarboxylase (DDC) is expressed in U937 cells, an important model of human…”
Get full text

Quantification and study of the L-DOPA decarboxylase expression in gastric adenocarcinoma cells treated with chemotherapeutic substances by Korbakis, Dimitrios, Fragoulis, Emmanuel G, Scorilas, Andreas

“…3,4-Dihydroxy-L-phenylalanine decarboxylase (DDC) is an enzyme implicated in the biosynthetic pathways of the neurotransmitters dopamine and probably…”
Get full text

l-Dopa decarboxylase expression profile in human cancer cells by Chalatsa, Ioanna, Nikolouzou, Eleftheria, Fragoulis, Emmanuel G, Vassilacopoulou, Dido

“…l-Dopa decarboxylase (DDC) catalyses the decarboxylation of l-Dopa. It has been shown that the DDC gene undergoes alternative splicing within its…”
Get full text

Effect of cytostatic drugs on the mRNA expression levels of ribonuclease κ in breast and ovarian cancer cells by Gkratsou, Asimina S, Fragoulis, Emmanuel G, Sideris, Diamantis C

“…Breast and ovarian cancers remain a major public health issue, constituting a major cause of female morbidity and mortality worldwide. Even though systemic…”
Get more information