Search Results - "Fraga, Sónia"

Editorial of Special Issue: The Toxicity of Nanomaterials and Legacy Contaminants: Risks to the Environment and Human Health by Reis, Ana Teresa, Costa, Carla, Fraga, Sónia

“…Nanotechnology and the incorporation of nanomaterials (NM) into everyday products help to solve problems in society and improve the quality of life, allowing…”
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Cell Model of Depression: Reduction of Cell Stress with Mirtazapine by Correia, Ana Salomé, Fraga, Sónia, Teixeira, João Paulo, Vale, Nuno

“…Depression is a very prevalent and complex disease. This condition is associated with a high rate of relapse, making its treatment a challenge. Thus, an…”
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How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets by Moreira, Luciana, Costa, Carla, Pires, Joana, Teixeira, João Paulo, Fraga, Sónia

“…•Overview of the in vitro/in vivo epigenetic changes induced by widely used ENM.•ENM induce epigenetic changes at DNA methylation, histone and ncRNA…”
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Short- and long-term distribution and toxicity of gold nanoparticles in the rat after a single-dose intravenous administration by Fraga, Sónia, PhD, Brandão, Ana, MSc, Soares, Maria Elisa, BSc, Morais, Tiago, MSc, Duarte, José Alberto, MD PhD, Pereira, Laura, BSc, Soares, Leonor, MSc, Neves, Cristina, PhD, Pereira, Eulália, PhD, Bastos, Maria de Lourdes, PharmD PhD, Carmo, Helena, PharmD PhD

“…Abstract Surface chemistry plays an important role in gold nanoparticles (AuNPs) stability and biocompatibility, which are crucial for their implementation…”
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Impact of gold nanoparticle exposure on genetic material by Ramos-Pan, Lucía, Touzani, Assia, Fernández-Bertólez, Natalia, Fraga, Sónia, Laffon, Blanca, Valdiglesias, Vanessa

“…Metal nanoparticles, with gold nanoparticles (AuNP) at the forefront, have gained immense attention due to their unique properties. At the nanoscale, gold…”
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Nanoparticle exposure and hazard in the ceramic industry: an overview of potential sources, toxicity and health effects by Bessa, Maria João, Brandão, Fátima, Viana, Mar, Gomes, João F., Monfort, Eliseo, Cassee, Flemming R., Fraga, Sónia, Teixeira, João Paulo

“…The ceramic industry is an industrial sector of great impact in the global economy that has been benefiting from advances in materials and processing…”
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Toxicological impact of acute exposure to E171 food additive and TiO2 nanoparticles on a co-culture of Caco-2 and HT29-MTX intestinal cells by Dorier, Marie, Tisseyre, Céline, Dussert, Fanny, Béal, David, Arnal, Marie-Edith, Douki, Thierry, Valdiglesias, Vanessa, Laffon, Blanca, Fraga, Sónia, Brandão, Fátima, Herlin-Boime, Nathalie, Barreau, Frédérick, Rabilloud, Thierry, Carriere, Marie

“…•A co-culture of Caco-2 and HT29-MTX was used as a model of intestinal epithelium.•These cells were acutely exposed to TiO2, either as E171 food additive or as…”
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Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models by Bessa, Maria João, Brandão, Fátima, Rosário, Fernanda, Moreira, Luciana, Reis, Ana Teresa, Valdiglesias, Vanessa, Laffon, Blanca, Fraga, Sónia, Teixeira, João Paulo

“…Several studies have been conducted to address the potential adverse health risks attributed to exposure to nanoscale materials. While in vivo studies are…”
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Suitability of salivary leucocytes to assess DNA repair ability in human biomonitoring studies by the challenge-comet assay by Fernández-Bertólez, Natalia, Lema-Arranz, Carlota, Fraga, Sónia, Teixeira, João Paulo, Pásaro, Eduardo, Lorenzo-López, Laura, Valdiglesias, Vanessa, Laffon, Blanca

“…The challenge-comet assay is a simple but effective approach that provides a quantitative and functional determination of DNA repair ability, and allows to…”
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Influence of the surface coating on the cytotoxicity, genotoxicity and uptake of gold nanoparticles in human HepG2 cells by Fraga, Sónia, Faria, Helena, Soares, Maria Elisa, Duarte, José Alberto, Soares, Leonor, Pereira, Eulália, Costa-Pereira, Cristiana, Teixeira, João Paulo, de Lourdes Bastos, Maria, Carmo, Helena

“…ABSTRACT The toxicological profile of gold nanoparticles (AuNPs) remains controversial. Significant efforts to develop surface coatings to improve…”
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In vitro genotoxicity assessment of an oxidized dextrin‐based hydrogel for biomedical applications by Pereira, Isabel, Fraga, Sónia, Silva, Susana, Teixeira, João Paulo, Gama, Miguel

“…Hydrogels are three‐dimensional, crosslinked networks of hydrophilic polymers swollen with a large amount of water or biological fluids, without dissolving…”
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Moving into advanced nanomaterials. Toxicity of rutile TiO2 nanoparticles immobilized in nanokaolin nanocomposites on HepG2 cell line by Bessa, Maria João, Costa, Carla, Reinosa, Julian, Pereira, Cristiana, Fraga, Sónia, Fernández, José, Bañares, Miguel A., Teixeira, João Paulo

“…Immobilization of nanoparticles on inorganic supports has been recently developed, resulting in the creation of nanocomposites. Concerning titanium dioxide…”
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The role of salt-inducible kinases on the modulation of renal and intestinal Na+,K+-ATPase activity during short- and long-term high-salt intake by António, Tatiana, Cosme, Dina, Igreja, Bruno, Fraga, Sónia, Serrão, Maria Paula, Pires, Nuno M., Soares-da-Silva, Patrício

“…Type 1 salt-inducible kinases (SIK1) has been shown to act as a mediator during the cellular adaptation to variations in intracellular sodium in a variety of…”
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Unveiling the Toxicity of Fine and Nano-Sized Airborne Particles Generated from Industrial Thermal Spraying Processes in Human Alveolar Epithelial Cells by Bessa, Maria João, Brandão, Fátima, Fokkens, Paul H B, Leseman, Daan L A C, Boere, A John F, Cassee, Flemming R, Salmatonidis, Apostolos, Viana, Mar, Monfort, Eliseo, Fraga, Sónia, Teixeira, João Paulo

“…High-energy industrial processes have been associated with particle release into workplace air that can adversely affect workers' health. The present study…”
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Multiparametric in vitro genotoxicity assessment of different variants of amorphous silica nanomaterials in rat alveolar epithelial cells by Brandão, Fátima, Costa, Carla, Bessa, Maria João, Valdiglesias, Vanessa, Hellack, Bryan, Haase, Andrea, Fraga, Sónia, Teixeira, João Paulo

“…The hazard posed to human health by inhaled amorphous silica nanomaterials (aSiO2 NM) remains uncertain. Herein, we assessed the cyto- and genotoxicity of…”
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l-proline supplementation improves nitric oxide bioavailability and counteracts the blood pressure rise induced by angiotensin II in rats by Leal, Joana, Teixeira-Santos, Luísa, Pinho, Dora, Afonso, Joana, Carvalho, Jorge, de Lourdes Bastos, Maria, Albino-Teixeira, António, Fraga, Sónia, Sousa, Teresa

“…We evaluated whether l-proline (Pro) supplementation improves redox status and nitric oxide (NO) bioavailability and prevents or delays angiotensin II…”
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Genotoxicity of TiO2 Nanoparticles in Four Different Human Cell Lines (A549, HEPG2, A172 and SH-SY5Y) by Brandão, Fátima, Fernández-Bertólez, Natalia, Rosário, Fernanda, Bessa, Maria João, Fraga, Sónia, Pásaro, Eduardo, Teixeira, João Paulo, Laffon, Blanca, Valdiglesias, Vanessa, Costa, Carla

“…Titanium dioxide nanoparticles (TiO2 NPs) have a wide variety of applications in many consumer products, including as food additives, increasing the concern…”
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Toxicity assessment of industrial engineered and airborne process-generated nanoparticles in a 3D human airway epithelial in vitro model by Bessa, Maria João, Brandão, Fátima, Fokkens, Paul, Cassee, Flemming R., Salmatonidis, Apostolos, Viana, Mar, Vulpoi, Adriana, Simon, Simion, Monfort, Eliseo, Teixeira, João Paulo, Fraga, Sónia

“…The advanced ceramic technology has been pointed out as a potentially relevant case of occupational exposure to nanoparticles (NP). Not only when nanoscale…”
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In vivo systemic toxicity assessment of an oxidized dextrin‐based hydrogel and its effectiveness as a carrier and stabilizer of granular synthetic bone substitutes by Pereira, Isabel, Fraga, Sónia, Maltez, Luís, Requicha, João, Guardão, Luísa, Oliveira, Joana, Prada, Justina, Alves, Helena, Santos, José Domingos, Teixeira, João Paulo, Pereira, José Eduardo, Soares, Raquel, Gama, Francisco Miguel

“…The worldwide incidence of bone disorders is raising, mainly due to aging population. The lack of effective treatments is pushing the development of synthetic…”
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Effect of surface coating on the biodistribution profile of gold nanoparticles in the rat by Morais, Tiago, Soares, Maria Elisa, Duarte, José Alberto, Soares, Leonor, Maia, Sílvia, Gomes, Paula, Pereira, Eulália, Fraga, Sónia, Carmo, Helena, Bastos, Maria de Lourdes

“…The kinetic and biodistribution profile of citrate-, 11-MUA- and pentapeptide-coated gold nanoparticles (AuNPs) intravenously injected in the rat was evaluated…”
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