Treatment of keloids and hypertrophic scars. Position statement of the Brazilian expert group GREMCIQ

Keloids (K) and hypertrophic scars (HS) are abnormal responses to wound healing that occur as the result of dermal inflammation. Despite the advances on their treatment, many patients still suffer from the negative effects of excessive scarring; its approach is impaired by the lack of objective data...

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Bibliographic Details
Published in:	Journal of the European Academy of Dermatology and Venereology Vol. 35; no. 11; pp. 2128 - 2142
Main Authors:	Oliveira, G.V., Metsavaht, L.D., Kadunc, B.V, Jedwab, S.K.K., Bressan, M.S., Stolf, H.O., Castro, R.G., Bezerra, S.M.F.M.C., Calil, D.A., Addor, F.A.Z., Fraga, J.C.S., Reis, C.M.S., Reis‐Filho, E., Silva, M.R., Ramos‐e‐Silva, M., Hexsel, D.M.
Format:	Journal Article
Language:	English
Published:	England 01-11-2021
Subjects:	Brazil Cicatrix, Hypertrophic - genetics Cicatrix, Hypertrophic - pathology Cicatrix, Hypertrophic - therapy Humans Keloid - genetics Keloid - pathology Keloid - therapy Brazil
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Summary:	Keloids (K) and hypertrophic scars (HS) are abnormal responses to wound healing that occur as the result of dermal inflammation. Despite the advances on their treatment, many patients still suffer from the negative effects of excessive scarring; its approach is impaired by the lack of objective data on different treatments and the large genetic variability among patients and the difficulties in producing multicentre studies. Their incidence among the Brazilian population is high, as the result of an admixture of Amerindians, Europeans and Africans ancestral roots. With the aim of producing multicentre studies on K and HS, a panel of senior Brazilian dermatologists focused on their treatment was invited to contribute with the K and HS Treatment Brazilian Guidelines. In the first part of this study, different treatment modalities for keloids and HS are fully reviewed by the panel. The second part of the study presents a consensus recommendation of treatment for different types of lesions. More than a literature review, this article aims to show the pitfalls and pearls of each therapeutic option, as well as a therapeutic approach by the Panel of Experts on keloids and Scars on a highly mixed population, providing simple guidelines.
Bibliography:	None. Conflicts of Interest Oliveira GV‐Speaker, USK, 2020; Metsavaht LD – none; Kadunc BV – none; Jedwab SKK – none; Stolf HO – none; Castro RG – Merz, Megalabs, Naos – Speaker; Bezerra SMFMC – none; Calil DA – none; Addor FAZ – none; Fraga JCS – none; Reis CMS – none; Reis‐Filho E – none; Silva MR – none; Ramos‐e‐Silva M – none; Hexsel DM – none; Bressan MS – none. Funding source ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Instructional Material/Guideline-4
ISSN:	0926-9959 1468-3083
DOI:	10.1111/jdv.17484