Search Results - "Fraga, CAM"

Design, synthesis and antiinflammatory activity of novel phthalimide derivatives, structurally related to thalidomide by Machado, Alexandre Légora, Lima, Lı́dia Moreira, Araújo-Jr, João Xavier, Fraga, Carlos Alberto M., Gonçalves Koatz, Vera Lúcia, Barreiro, Eliezer J.

“…The synthesis and antiinflammatory activity of novel N-phenyl-phthalimide functionalized ( 4a– d, 5a, b, 6a, b) derivatives is described. As part of an ongoing…”
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N-Acylhydrazones as drugs by Thota, Sreekanth, Rodrigues, Daniel A., Pinheiro, Pedro de Sena Murteira, Lima, Lídia M., Fraga, Carlos A.M., Barreiro, Eliezer J.

“…[Display omitted] •N-Acylhydrazone (NAH) motif in Drug Design and Medicinal Chemistry.•NAH-related approved drugs.•N-Acylhydrazone motif scaffolds in clinical…”
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Privileged structures: a useful concept for the rational design of new lead drug candidates by Duarte, Carolina D, Barreiro, Eliezer J, Fraga, Carlos A M

“…Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by…”
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Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2- a]pyridine symbiotic prototypes by Lacerda, Renata B., de Lima, Cleverton K.F., da Silva, Leandro L., Romeiro, Nelilma C., Miranda, Ana Luisa P., Barreiro, Eliezer J., Fraga, Carlos A.M.

“…We describe herein the discovery of LASSBio-1135 ( 3a) as a novel in vivo antinociceptive and anti-inflammatory symbiotic prototype that act as selective…”
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Synthesis and analgesic profile of novel N-containing heterocycle derivatives: arylidene 3-phenyl-1,2,4-oxadiazole-5-carbohydrazide by Leite, Lúcia Fernanda C.C., Ramos, Mozart N., da Silva, João Bosco P., Miranda, Ana L.P., Fraga, Carlos A.M., Barreiro, Eliezer J.

“…This paper describes recent results of a research program aimed at the synthesis and pharmacological evaluation of new heterocyclic N-acylhydrazone (NAH)…”
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Medicinal chemistry of N-acylhydrazones: new lead-compounds of analgesic, antiinflammatory and antithrombotic drugs by Fraga, Carlos A M, Barreiro, Eliezer J

“…In this article we provide an overview on the medicinal chemistry of new bioactive N-acylhydrazone (NAH) derivatives designed through the structural…”
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Synthesis and anti-inflammatory activity of phthalimide derivatives, designed as new thalidomide analogues by Lima, Lı́dia M, Castro, Paulo, Machado, Alexandre L, Fraga, Carlos Alberto M, Lugnier, Claire, de Moraes, Vera Lúcia Gonçalves, Barreiro, Eliezer J

“…This paper describes the synthesis and anti-inflammatory activity of new N-phenyl-phthalimide sulfonamides ( 3a– e) and the isosters N-phenyl-phthalimide…”
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Synthesis and vasodilatory activity of new N-acylhydrazone derivatives, designed as LASSBio-294 analogues by Silva, Alexandre G., Zapata-Sudo, Gisele, Kummerle, Arthur E., Fraga, Carlos A.M., Barreiro, Eliezer J., Sudo, Roberto T.

“…New derivatives of LASSBio-294 were designed and tested on the contractile response of vascular smooth muscle from Wistar rats. LASSBio-785 (IC 50 = 10.2 μM)…”
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New class of potent antinociceptive and antiplatelet 10H-phenothiazine-1-acylhydrazone derivatives by SILVA, Gildasio A, COSTA, Luciana M. M, BRITO, Fernanda C. F, MIRANDA, Ana L. P, BARREIRO, Eliezer J, FRAGA, Carlos A. M

“…In this work, we reported the synthesis and evaluation of the analgesic, antiinflammatory, and antiplatelet properties of new phenothiazine-attached…”
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Antiplatelet properties of novel N-substituted-phenyl-1,2,3-triazole-4-acylhydrazone derivatives by Cunha, Anna C., Figueiredo, Juliana M., Tributino, Jorge L.M., Miranda, Ana L.P., Castro, Helena C., Zingali, Russolina B., Fraga, Carlos A.M., de Souza, Maria Cecı́lia B.V., Ferreira, Vitor F., Barreiro, Eliezer J.

“…This paper describes the design, synthesis and pharmacological evaluation of new N-acylhydrazone (NAH) compounds, belonging to the…”
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Adenosine A2Areceptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction by da Silva JS, Gabriel-Costa D, Sudo RT, Wang H, Groban L, Ferraz EB, Nascimento JHM, Fraga CAM, Barreiro EJ, Zapata-Sudo G

“…Jaqueline S da Silva,1 Daniele Gabriel-Costa,1 Roberto T Sudo,1 Hao Wang,2 Leanne Groban,2 Emanuele B Ferraz,3 José Hamilton M Nascimento,3 Carlos Alberto M…”
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Synthesis and antitrypanosomal profile of new functionalized 1,3,4-thiadiazole-2-arylhydrazone derivatives, designed as non-mutagenic megazol analogues by Carvalho, Samir A., da Silva, Edson F., Santa-Rita, Ricardo M., de Castro, Solange L., Fraga, Carlos A.M.

“…The synthesis of the new powerful trypanocidal agent brazilizone A ( 4k) (IC 50/24 h = 5.3 μM) is reported. In this work we reported the synthesis and the…”
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Design, Synthesis, and Pharmacological Profile of Novel Fused Pyrazolo[4,3-d]pyridine and Pyrazolo[3,4-b][1,8]naphthyridine Isosteres:  A New Class of Potent and Selective Acetylcholinesterase Inhibitors by Barreiro, Eliezer J, Camara, Celso A, Verli, Hugo, Brazil-Más, Leonora, Castro, Newton G, Cintra, Wagner M, Aracava, Yasco, Rodrigues, Carlos R, Fraga, Carlos A. M

“…A new family of tacrine (THA) analogues (7−9, 12), containing the azaheterocyclic pyrazolo[4,3-d]pyridine or pyrazolo[3,4-b][1,8]naphthyridine systems as…”
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Synthesis and analgesic activity of novel N-acylarylhydrazones and isosters, derived from natural safrole by Lima, Patrícia C., Lima, Lídia M., da Silva, Kelli Cristine M., Léda, Paulo Henrique O., de Miranda, Ana Luisa P., Fraga, Carlos A.M., Barreiro, Eliezer J.

“…Anew series of antinociceptive compounds belonging to the N-acylarylhydrazone (NAH) class were synthesized from natural safrole ( 7). The most analgesic…”
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Design, synthesis, and pharmacological evaluation of new neuroactive pyrazolo[3,4- b]pyrrolo[3,4- d]pyridine derivatives with in vivo hypnotic and analgesic profile by Menegatti, Ricardo, Silva, Gilberto M.S., Zapata-Sudo, Gisele, Raimundo, Juliana M., Sudo, Roberto T., Barreiro, Eliezer J., Fraga, Carlos A.M.

“…The new powerful central-acting heterotricyclic analgesic agent LASSBio-873 ( 5) is reported. The present study describes the synthesis and pharmacological…”
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Design, synthesis and pharmacological profile of novel dopamine D2 receptor ligands by Menegatti, Ricardo, Cunha, Anna C, Ferreira, Vı́tor F, Perreira, Edna F.R, El-Nabawi, Ahmed, Eldefrawi, Amira T, Albuquerque, Edson X, Neves, Gilda, Rates, Stela M.K, Fraga, Carlos A.M, Barreiro, Eliezer J

“…The present study describes the synthesis and pharmacological profile of three novel heterocyclic compounds originally designed, on the basis of bioisosterism,…”
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New selective acetylcholinesterase inhibitors designed from natural piperidine alkaloids by Viegas, Cláudio, Bolzani, Vanderlan S., Pimentel, Luísa S.B., Castro, Newton G., Cabral, Rafael F., Costa, Rodrigo S., Floyd, Corinne, Rocha, Mônica S., Young, Maria C.M., Barreiro, Eliezer J., Fraga, Carlos A.M.

“…The two new piperidine modified alkaloids 7 and 9 are described as selective acetylcholinesterase inhibitors, IC 50 = 7.3 and 15.1 μM, respectively. Five new…”
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Impairment of locomotor activity induced by the novel N-acylhydrazone derivatives LASSBio-785 and LASSBio-786 in mice by Silva, G A P, Kummerle, A E, Antunes, F, Fraga, C A M, Barreiro, E J, Zapata-Sudo, G, Sudo, R T

“…The N-acylhydrazone (NAH) analogues N-methyl 2-thienylidene 3,4-benzoylhydrazine (LASSBio-785) and N-benzyl 2-thienylidene 3,4-benzoylhydrazine (LASSBio-786)…”
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Sedation and antinociception induced by a new pyrazolo[3,4- b]pyrrolo[3,4- d]pyridine derivative (LASSBio-873) is modulated by activation of muscarinic receptors by Mendes, Thaiana C.F., Raimundo, Juliana M., Nascimento-Junior, Nailton M., Fraga, Carlos A.M., Barreiro, Eliezer J., Sudo, Roberto T., Zapata-Sudo, Gisele

“…New substances designed for the treatment of anxiety have previously been synthesized, which resulted in the identification of four new pyrazolo[3,4-…”
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LASSBio‐881: an N‐acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation by Tributino, JLM, Santos, MLH, Mesquita, CM, Lima, CKF, Silva, LL, Maia, RC, Duarte, CD, Barreiro, EJ, Fraga, CAM, Castro, NG, Miranda, ALP, Guimaraes, MZP

“…Background and purpose:  Compound LASSBio‐881 is an orally effective antinociceptive that binds to cannabinoid receptors and is active mainly on the neurogenic…”
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