Search Results - "Frackowiak, Joanna E."
-
1
The interactions of monomeric acridines and unsymmetrical bisacridines (UAs) with DNA duplexes: an insight provided by NMR and MD studies
Published in Scientific reports (01-03-2023)“…Members of a novel class of anticancer compounds, exhibiting high antitumor activity, i.e. the unsymmetrical bisacridines (UAs), consist of two heteroaromatic…”
Get full text
Journal Article -
2
Acid–Base Equilibrium and Self-Association in Relation to High Antitumor Activity of Selected Unsymmetrical Bisacridines Established by Extensive Chemometric Analysis
Published in Molecules (Basel, Switzerland) (21-06-2022)“…Unsymmetrical bisacridines (UAs) represent a novel class of anticancer agents previously synthesized by our group. Our recent studies have demonstrated their…”
Get full text
Journal Article -
3
Potential of Silver Nanoparticles in Overcoming the Intrinsic Resistance of Pseudomonas aeruginosa to Secondary Metabolites from Carnivorous Plants
Published in International journal of molecular sciences (01-05-2021)“…Carnivorous plants are exemplary natural sources of secondary metabolites with biological activity. However, the therapeutic antimicrobial potential of these…”
Get full text
Journal Article -
4
Exposure of Keratinocytes to Candida Albicans in the Context of Atopic Milieu Induces Changes in the Surface Glycosylation Pattern of Small Extracellular Vesicles to Enhance Their Propensity to Interact With Inhibitory Siglec Receptors
Published in Frontiers in immunology (2022)“…infection is a potential complication in the individuals with atopic dermatitis (AD) and can affect clinical course of the disease. Here, using primary…”
Get full text
Journal Article -
5
Changes in the Expression of Transcription Factors Involved in Modulating the Expression of EPO-R in Activated Human CD4-Positive Lymphocytes
Published in PloS one (05-04-2013)“…We have recently described the presence of the erythropoietin receptor (EPO-R) on CD4(+) lymphocytes and demonstrated that its expression increases during…”
Get full text
Journal Article -
6
Distinct cellular uptake patterns of two anticancer unsymmetrical bisacridines and their metabolic transformation in tumor cells
Published in Journal of pharmaceutical and biomedical analysis (01-01-2025)“…Unsymmetrical bisacridines (UAs) represent a novel class of anticancer agents. Their high cytotoxicity towards multiple human cancer cell lines and inhibition…”
Get full text
Journal Article -
7
Keratinocyte-derived small extracellular vesicles supply antigens for CD1a-resticted T cells and promote their type 2 bias in the context of filaggrin insufficiency
Published in Frontiers in immunology (2024)“…Exosome-enriched small extracellular vesicles (sEVs) are nanosized organelles known to participate in long distance communication between cells, including in…”
Get full text
Journal Article -
8
Synthesis of antimicrobial silver nanoparticles through a photomediated reaction in an aqueous environment
Published in International journal of nanomedicine (01-01-2016)“…A fast, economical, and reproducible method for nanoparticle synthesis has been developed in our laboratory. The reaction is performed in an aqueous…”
Get full text
Journal Article -
9
Roles of calpain-calpastatin system (CCS) in human T cell activation
Published in Oncotarget (22-11-2016)“…The immune response is determined by the speed of the T cell reaction to antigens assured by a state of readiness for proliferation and cytokine secretion…”
Get full text
Journal Article -
10
Increased μ-Calpain Activity in Blasts of Common B-Precursor Childhood Acute Lymphoblastic Leukemia Correlates with Their Lower Susceptibility to Apoptosis
Published in PloS one (28-08-2015)“…Childhood acute lymphoblastic leukemia (ALL) blasts are characterized by inhibited apoptosis promoting fast disease progress. It is known that in chronic…”
Get full text
Journal Article -
11
Increased [mu]-Calpain Activity in Blasts of Common B-Precursor Childhood Acute Lymphoblastic Leukemia Correlates with Their Lower Susceptibility to Apoptosis
Published in PloS one (28-08-2015)“…Childhood acute lymphoblastic leukemia (ALL) blasts are characterized by inhibited apoptosis promoting fast disease progress. It is known that in chronic…”
Get full text
Journal Article -
12
Increased M-Calpain Activity in Blasts of Common B-Precursor Childhood Acute Lymphoblastic Leukemia Correlates with Their Lower Susceptibility to Apoptosis: e0136615
Published in PloS one (01-08-2015)“…Childhood acute lymphoblastic leukemia (ALL) blasts are characterized by inhibited apoptosis promoting fast disease progress. It is known that in chronic…”
Get full text
Journal Article -
13
Changes in the Expression of Transcription Factors Involved in Modulating the Expression of EPO-R in Activated Human CD4-Positive Lymphocytes. e60326
Published in PloS one (01-04-2013)“…We have recently described the presence of the erythropoietin receptor (EPO-R) on CD4+ lymphocytes and demonstrated that its expression increases during their…”
Get full text
Journal Article -
14
O07 Filaggrin insufficiency renders keratinocyte-derived small extracellular vesicles capable of affecting CD1a-mediated T-cell responses and promoting allergic inflammation
Published in British journal of dermatology (1951) (07-07-2023)“…The association between FLG loss-of-function mutations and the development of atopic dermatitis (AD) indicates that filaggrin is critical to skin barrier…”
Get full text
Journal Article