Search Results - "Frachon, Paule"
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Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins
Published in Molecular biology of the cell (01-12-2002)“…Mitochondrial fusion remains a largely unknown process despite its observation by live microscopy and the identification of few implicated proteins. Using…”
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2
Organization and dynamics of human mitochondrial DNA
Published in Journal of cell science (01-06-2004)“…Heteroplasmic mutations of mitochondrial DNA (mtDNA) are an important source of human diseases. The mechanisms governing transmission, segregation and…”
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3
Late-onset mitochondrial DNA depletion: DNA copy number, multiple deletions, and compensation
Published in Annals of neurology (01-05-2001)“…Through a report of 4 late‐onset cases with mitochondrial DNA (mtDNA) depletion, we address the specificity of the clinical entities associated with a very low…”
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4
Development and implementation of standardized respiratory chain spectrophotometric assays for clinical diagnosis
Published in Mitochondrion (01-09-2009)“…Diversity of respiratory chain spectrophotometric assays may lead to difficult comparison of results between centers. The French network of mitochondrial…”
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5
Respiratory mutations lead to different pleiotropic effects on OXPHOS complexes in yeast and in human cells
Published in FEBS letters (15-10-2008)“…Pleiotropic effects in the oxidative phosphorylation pathway (OXPHOS) were investigated in yeast respiratory mutants and in cells from patients with OXPHOS…”
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Mitochondrial toxicity of indinavir, stavudine and zidovudine involves multiple cellular targets in white and brown adipocytes
Published in Antiviral therapy (01-01-2007)“…To evaluate the mechanisms of mitochondrial toxicity associated with antiretroviral treatment. 3T3-F442A white and T37i brown adipocytes were exposed to…”
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7
Mitochondrial Fusion in Human Cells Is Efficient, Requires the Inner Membrane Potential, and Is Mediated by MitofusinsV
Published in Molecular biology of the cell (01-12-2002)“…Mitochondrial fusion remains a largely unknown process despite its observation by live microscopy and the identification of few implicated proteins. Using…”
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8
Mitochondrial toxicity of indinavir, stavudine and zidovudine involves multiple cellular targets in white and brown adipocytes: Adipocyte mitochondrial toxicity of antiHIV drugs
Published in Antiviral therapy (2007)“…OBJECTIVE: To evaluate the mechanisms of mitochondrial toxicity associated with antiretroviral treatment. METHODS: 3T3-F442A white and T37i brown adipocytes…”
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9
Mitochondrial toxicity of indinavir, stavudine and zidovudine involves multiple cellular targets in white and brown adipocytes: Adipocyte mitochondrial toxicity of antiHIV drugs
Published in Antiviral therapy (2007)“…OBJECTIVE: To evaluate the mechanisms of mitochondrial toxicity associated with antiretroviral treatment. METHODS: 3T3-F442A white and T37i brown adipocytes…”
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10
Functional characterization of novel mutations in the human cytochrome b gene
Published in European journal of human genetics : EJHG (01-07-2001)“…The great variability of the human mitochondrial DNA (mtDNA) sequence induces many difficulties in the search for its deleterious mutations. We illustrate…”
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Functional mitochondrial heterogeneity in heteroplasmic cells carrying the mitochondrial DNA mutation associated with the MELAS syndrome (mitochondrial encephalopathy, lactic acidosis, and strokelike episodes)
Published in Pediatric research (01-08-2000)“…Most mitochondrial DNA (mtDNA) alterations associated with human disorders are heteroplasmic, i.e. mutant mtDNA molecules coexist with normal ones within the…”
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12
Immunization with a peptide having both T cell and conformationally restricted B cell epitopes elicits neutralizing antisera against a snake neurotoxin
Published in The Journal of immunology (1950) (15-12-1990)“…We have synthesized a free peptide capable of eliciting antibodies that neutralize toxin alpha from Naja nigricollis, a protein that binds specifically to the…”
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13
Evidence that the anti‐coagulant and lethal properties of a basic phospholipase A 2 from snake venom are unrelated
Published in FEBS letters (08-05-1989)“…The basic phospholipase A 2 (PLA 2 ) from venom of the African elapid Naja nigricollis was previously shown to have anti‐coagulant and lethal properties, both…”
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14
Immunological properties of notexin, a potent presynaptic and myotoxic component from venom of the Australian tiger snake Notechis scutatus scutatus
Published in FEBS letters (03-07-1989)“…Neutralizing antibodies were raised in mice against notexin, the most toxic phospholipase A 2 (PLA 2) from Notechis scutatus scutatus venom, without the…”
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15
Isolation of Pure Cholinergic Nerve Endings from Torpedo Electric Organ: Evaluation of Their Metabolic Properties
Published in The Journal of cell biology (01-10-1977)“…Pure cholinergic nerve endings (synaptosomes) were isolated from the electric organ of Torpedo by a rapid procedure. These synaptosomes are ∼3 μm in diameter…”
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16
Evidence that the anti-coagulant and lethal properties of a basic phospholipase A2 from snake venom are unrelated
Published in FEBS letters (08-05-1989)“…The basic phospholipase A2 (PLA2) from venom of the African elapid Naja nigricollis was previously shown to have anti-coagulant and lethal properties, both of…”
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17
Selective distinction at equilibrium between the two α‐neurotoxin binding sites of Torpedo acetylcholine receptor by microtitration
Published in European journal of biochemistry (01-06-1988)“…The binding of the monoiodinated α‐neurotoxin I from Naja mossambica mossambica to the membrane‐bound acetylcholine receptor from Torpedo marmorata was…”
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