Surface-enhanced Raman spectroscopic study of DNA and 6-mercapto-1-hexanol interactions using large area mapping

The emergence of 2D SERS substrates with large areas of hot spots has enabled data to be gathered at large scale. This work presents a statistical tool for analysing large amounts of SERS data by utilizing a peak-fitting model in a specific spectral range. By analysing the distributions of Raman int...

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Bibliographic Details
Published in:	Vibrational spectroscopy Vol. 86; pp. 331 - 336
Main Authors:	Frøhling, Kasper Bayer, Alstrøm, Tommy Sonne, Bache, Michael, Schmidt, Michael Stenbæk, Schmidt, Mikkel Nørgaard, Larsen, Jan, Jakobsen, Mogens Havsteen, Boisen, Anja
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-09-2016
Subjects:	6-Mercapto-1-hexanol Area mapping DNA Gold Peak-fitting SERS Thiol Area mapping Gold Thiol Peak-fitting SERS DNA 6-Mercapto-1-hexanol
Online Access:	Get full text
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Summary:	The emergence of 2D SERS substrates with large areas of hot spots has enabled data to be gathered at large scale. This work presents a statistical tool for analysing large amounts of SERS data by utilizing a peak-fitting model in a specific spectral range. By analysing the distributions of Raman intensities and peak positions it is possible to directly inspect the interplay between DNA and 6-mercapto-1-hexanol on gold covered nanopillars. It is demonstrated that optimised functionalization parameters can be extracted from the Raman spectra directly. Using the peak-fitting approach it is possible to avoid miss-interpretation of intensity histograms, where contamination might contribute with an enhanced background and not a peak.
ISSN:	0924-2031 1873-3697
DOI:	10.1016/j.vibspec.2016.08.005