Search Results - "Frädrich, Caroline"

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture by Wagner, Ilka, Materne, Eva-Maria, Brincker, Sven, Süssbier, Ute, Frädrich, Caroline, Busek, Mathias, Sonntag, Frank, Sakharov, Dmitry A, Trushkin, Evgeny V, Tonevitsky, Alexander G, Lauster, Roland, Marx, Uwe

“…Current in vitro and animal tests for drug development are failing to emulate the systemic organ complexity of the human body and, therefore, to accurately…”
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Comparative analysis of thyroid hormone systems in rodents with subterranean lifestyle by Gerhardt, Patricia, Begall, Sabine, Frädrich, Caroline, Renko, Kostja, Hildebrandt, Thomas B., Holtze, Susanne, Heinrich, Alexandra, Sahm, Arne, Meci, Xheni, Köhrle, Josef, Rijntjes, Eddy, Henning, Yoshiyuki

“…African mole-rats are subterranean rodents inhabiting underground burrows. This habitat entails risks of overheating, hypoxia, and scarce food availability…”
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Low thyroxine serves as an upstream regulator of ecophysiological adaptations in Ansell's mole-rats by Gerhardt, Patricia, Begall, Sabine, Frädrich, Caroline, Renko, Kostja, Heinrich, Alexandra, Köhrle, Josef, Henning, Yoshiyuki

“…About 10% of all rodent species have evolved a subterranean way of life, although life in subterranean burrows is associated with harsh environmental…”
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Deiodinases control local cellular and systemic thyroid hormone availability by Köhrle, Josef, Frädrich, Caroline

“…Iodothyronine deiodinases (DIO) are a family of selenoproteins controlling systemic and local availability of the major thyroid hormone l-thyroxine (T4), a…”
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Thyroid hormone system disrupting chemicals by Köhrle, Josef, Frädrich, Caroline

“…The thyroid hormone system is a main target of endocrine disruptor compounds (EDC) at all levels of its intricately fine-tuned feedback regulation, synthesis,…”
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Testing for heterotopia formation in rats after developmental exposure to selected in vitro inhibitors of thyroperoxidase by Ramhøj, Louise, Frädrich, Caroline, Svingen, Terje, Scholze, Martin, Wirth, Eva K., Rijntjes, Eddy, Köhrle, Josef, Kortenkamp, Andreas, Axelstad, Marta

“…The thyroperoxidase (TPO) enzyme is expressed by the thyroid follicular cells and is required for thyroid hormone synthesis. In turn, thyroid hormones are…”
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Screening for endocrine disrupting chemicals inhibiting monocarboxylate 8 (MCT8) transporter facilitated thyroid hormone transport using a modified nonradioactive assay by Wagenaars, Fabian, Cenijn, Peter, Scholze, Martin, Frädrich, Caroline, Renko, Kostja, Köhrle, Josef, Hamers, Timo

“…Early neurodevelopmental processes are strictly dependent on spatial and temporally modulated of thyroid hormone (TH) availability and action. Thyroid hormone…”
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Perinatal exposure to the thyroperoxidase inhibitors methimazole and amitrole perturbs thyroid hormone system signaling and alters motor activity in rat offspring by Ramhøj, Louise, Svingen, Terje, Frädrich, Caroline, Rijntjes, Eddy, Wirth, Eva K., Pedersen, Katrine, Köhrle, Josef, Axelstad, Marta

“…[Display omitted] •TPO inhibitors MMI and amitrole elicit similar disruptions of the thyroid hormone system.•MMI and amitrole perturb thyroid hormone dependent…”
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Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals-The ATHENA Project by Kortenkamp, Andreas, Axelstad, Marta, Baig, Asma H, Bergman, Åke, Bornehag, Carl-Gustaf, Cenijn, Peter, Christiansen, Sofie, Demeneix, Barbara, Derakhshan, Arash, Fini, Jean-Baptiste, Frädrich, Caroline, Hamers, Timo, Hellwig, Lina, Köhrle, Josef, Korevaar, Tim I M, Lindberg, Johan, Martin, Olwenn, Meima, Marcel E, Mergenthaler, Philipp, Nikolov, Nikolai, Du Pasquier, David, Peeters, Robin P, Platzack, Bjorn, Ramhøj, Louise, Remaud, Sylvie, Renko, Kostja, Scholze, Martin, Stachelscheid, Harald, Svingen, Terje, Wagenaars, Fabian, Wedebye, Eva Bay, Zoeller, R Thomas

“…The test methods that currently exist for the identification of thyroid hormone system-disrupting chemicals are woefully inadequate. There are currently no…”
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Assessment of troglitazone induced liver toxicity in a dynamically perfused two-organ Micro-Bioreactor system by Materne, Eva-Maria, Frädrich, Caroline, Horland, Reyk, Hoffmann, Silke, Brincker, Sven, Lorenz, Alexandra, Busek, Mathias, Sonntag, Frank, Klotzbach, Udo, Lauster, Roland, Marx, Uwe, Wagner, Ilka

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Dynamic culture of human liver equivalents inside a micro-bioreactor for long-term substance testing by Materne, Eva-Maria, Wagner, Ilka, Frädrich, Caroline, Süßbier, Ute, Horland, Reyk, Hoffmann, Silke, Brincker, Sven, Lorenz, Alexandra, Gruchow, Matthias, Sonntag, Frank, Klotzbach, Udo, Lauster, Roland, Marx, Uwe

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