Search Results - "Fozzard, H A"

Mechanism of local anesthetic drug action on voltage-gated sodium channels by Fozzard, H A, Lee, P J, Lipkind, G M

“…Local anesthetic drugs interfere with excitation and conduction by action potentials in the nervous system and in the heart by blockade of the voltage-gated Na…”
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Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms by Fozzard, H A, Hanck, D A

“…Cardiac and nerve Na channels have broadly similar functional properties and amino acid sequences, but they demonstrate specific differences in gating,…”
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Isoform-dependent interaction of voltage-gated sodium channels with protons by Khan, A., Kyle, J. W., Hanck, D. A., Lipkind, G. M., Fozzard, H. A.

“…Protons are potent physiological modifiers of voltage-gated Na + channels, shifting the voltage range of channel gating and reducing current magnitude (p K a…”
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Role of outer ring carboxylates of the rat skeletal muscle sodium channel pore in proton block by Khan, A., Romantseva, L., Lam, A., Lipkind, G., Fozzard, H. A.

“…Voltage-gated Na + current is reduced by acid solution. Protons reduce peak Na + conductance by lowering single channel conductance and shift the voltage range…”
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A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel by Lipkind, G.M., Fozzard, H.A.

“…Biophysical evidence has placed the binding site for the naturally occurring marine toxins tetrodotoxin (TTX) and saxitoxin (STX) in the external mouth of the…”
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mu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains by Dudley, Jr, S C, Chang, N, Hall, J, Lipkind, G, Fozzard, H A, French, R J

“…Voltage-gated Na(+) channels underlie the electrical activity of most excitable cells, and these channels are the targets of many antiarrhythmic,…”
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Phosphorylation restores activity of L-type calcium channels after rundown in inside-out patches from rabbit cardiac cells by Ono, K, Fozzard, H A

“…1. Rundown of L-type calcium channels was studied in inside-out patches made from single isolated rabbit ventricular myocytes, using barium as the charge…”
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Toxin-Resistant Sodium Channels: Parallel Adaptive Evolution across a Complete Gene Family by Jost, Manda Clair, Hillis, David M., Lu, Ying, Kyle, John W., Fozzard, Harry A., Zakon, Harold H.

“…Approximately 75% of vertebrate proteins belong to protein families encoded by multiple evolutionarily related genes, a pattern that emerged as a result of…”
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Two phosphatase sites on the Ca2+ channel affecting different kinetic functions by Ono, K, Fozzard, H A

“…1. Changes in dihydropyridine-sensitive (L-type) Ca2+ channel kinetics were studied after prolongation of intrinsic phosphorylated time by the phosphatase…”
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Mechanism of cAMP-Dependent Modulation of Cardiac Sodium Channel Current Kinetics by Ono, Katsushige, Fozzard, Harry A, Hanck, Dorothy A

“…β-Adrenergic modulation is one of the most important regulatory mechanisms of ion channel function. Only recently, however, have β-adrenergic effects on…”
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A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule by Dudley, S.C., Todt, H., Lipkind, G., Fozzard, H.A.

“…We describe a mutation in the outer vestibule region of the adult rat skeletal muscle voltage-gated Na+ channel (microliter) that dramatically alters binding…”
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Sodium Channel Selectivity Filter Regulates Antiarrhythmic Drug Binding by Sunami, Akihiko, Dudley, Samuel C., Fozzard, Harry A.

“…Local anesthetic antiarrhythmic drugs block Na+channels and have important clinical uses. However, the molecular mechanism by which these drugs block the…”
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Adrenergic Modulation of the Transient Outward Current in Isolated Canine Purkinje Cells by Nakayama, Toshio, Fozzard, Harry A

“…Single canine Purkinje cells were voltage clamped under Ca-free conditions using the patch pipette. Depolarizing pulses from a holding potential of -42 mV…”
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A Critical Residue for Isoform Difference in Tetrodotoxin Affinity Is a Molecular Determinant of the External Access Path for Local Anesthetics in the Cardiac Sodium Channel by Sunami, Akihiko, Glaaser, Ian W., Fozzard, Harry A.

“…Membrane-impermeant quaternary derivatives of lidocaine (QX222 and QX314) block cardiac Na+channels when applied from either side of the membrane, but they…”
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Dose-Dependent Modulation of the Cardiac Sodium Channel by Sea Anemone Toxin ATXII by El-Sherif, Nabil, Fozzard, Harry A, Hanck, Dorothy A

“…The effects of sea anemone toxin ATXII on single sodium channels were studied in cell-attached patches on rabbit ventricular myocytes at 20–22°C. Exposure of…”
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Afterdepolarizations and triggered activity by Fozzard, H A

“…One of the possible cellular mechanisms for certain types of ventricular arrhythmias is afterdepolarizations. There are two types of afterdepolarization. The…”
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Nonlinear relation between Vmax and INa in canine cardiac Purkinje cells by SHEETS, M. F, HANCK, D. A, FOZZARD, H. A

“…We studied the relation of the maximal upstroke velocity (Vmax) of action potentials to the peak sodium current (INa) under voltage clamp in single, internally…”
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Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics by Sunami, A, Glaaser, I W, Fozzard, H A

“…Membrane-impermeant quaternary amine local anesthetics QX314 and QX222 can access their binding site on the cytoplasmic side of the selectivity filter from the…”
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KcsA Crystal Structure as Framework for a Molecular Model of the Na+ Channel Pore by Lipkind, Gregory M, Fozzard, Harry A

“…The crystal structure of the pore-forming part of the KcsA bacterial K+-selective channel suggests a possible motif for related voltage-gated channels. We…”
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Kinetic analysis of single sodium channels from canine cardiac Purkinje cells by SCANLEY, B. E, HANCK, D. A, CHAY, T, FOZZARD, H. A

“…Single sodium channel events were recorded from cell-attached patches on single canine cardiac Purkinje cells at 10-13 degrees C. Data from four patches…”
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