Search Results - "Fox, Keith R."

The effects of DNA supercoiling on G-quadruplex formation by Sekibo, Doreen A T, Fox, Keith R

“…Guanine-rich DNAs can fold into four-stranded structures that contain stacks of G-quartets. Bioinformatics studies have revealed that G-rich sequences with the…”
Get full text

Formation of stable DNA triplexes by Fox, Keith R, Brown, Tom

“…Triple-helical nucleic acids are formed by binding an oligonucleotide within the major groove of duplex DNA. These complexes offer the possibility of designing…”
Get more information

Synthesis and Biological Evaluation of a Novel C8-Pyrrolobenzodiazepine (PBD) Adenosine Conjugate. A Study on the Role of the PBD Ring in the Biological Activity of PBD-Conjugates by Ferguson, Lindsay, Bhakta, Sanjib, Fox, Keith R, Wells, Geoff, Brucoli, Federico

“…Here we sought to evaluate the contribution of the PBD unit to the biological activity of PBD-conjugates and, to this end, an adenosine nucleoside was attached…”
Get full text

Structural basis of DNA duplex distortion induced by thiazole-containing hairpin polyamides by Padroni, Giacomo, Parkinson, John A, Fox, Keith R, Burley, Glenn A

“…Abstract This manuscript reports the molecular basis for double-stranded DNA (dsDNA) binding of hairpin polyamides incorporating a 5-alkyl thiazole (Nt) unit…”
Get full text

Effect of G-Tract Length on the Topology and Stability of Intramolecular DNA Quadruplexes by Rachwal, Phillip A, Brown, Tom, Fox, Keith R

“…G-Rich sequences are known to form four-stranded structures that are based on stacks of G-quartets, and sequences with the potential to adopt these structures…”
Get full text

Sequence effects of single base loops in intramolecular quadruplex DNA by Rachwal, Phillip A., Brown, Tom, Fox, Keith R.

“…We have examined the properties of intramolecular G-quadruplexes in which the G3 tracts are separated by single base loops. The most stable complex contained…”
Get full text

Triplex-Directed Recognition of a DNA Nanostructure Assembled by Crossover Strand Exchange by Rusling, David A, Nandhakumar, Iris S, Brown, Tom, Fox, Keith R

“…DNA has been widely exploited for the self-assembly of nanosized objects and arrays that offer the potential to act as scaffolds for the spatial positioning of…”
Get full text

DNA sequence-selective C8-linked pyrrolobenzodiazepine–heterocyclic polyamide conjugates show anti-tubercular-specific activities by Brucoli, Federico, Guzman, Juan D, Basher, Mohammad A, Evangelopoulos, Dimitrios, McMahon, Eleanor, Munshi, Tulika, McHugh, Timothy D, Fox, Keith R, Bhakta, Sanjib

“…New chemotherapeutic agents with novel mechanisms of action are in urgent need to combat the tuberculosis pandemic. A library of 12 C8-linked pyrrolo[2,1- c…”
Get full text

A mutant of uracil DNA glycosylase that distinguishes between cytosine and 5-methylcytosine by Kimber, Scott T, Brown, Tom, Fox, Keith R

“…We demonstrate that a mutant of uracil DNA glycosylase (N123D:L191A) distinguishes between cytosine and methylcytosine. Uracil DNA glycosylase (UDG)…”
Get full text

DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapies by Procopiou, George, Jackson, Paul J. M., di Mascio, Daniella, Auer, Jennifer L., Pepper, Chris, Rahman, Khondaker Miraz, Fox, Keith R., Thurston, David E.

“…Antibody-Drug Conjugates (ADCs) are growing in importance for the treatment of both solid and haematological malignancies. There is a demand for new payloads…”
Get full text

DNA Structural Changes Induced by Intermolecular Triple Helix Formation by Sayoh, Ibrahim, Rusling, David A, Brown, Tom, Fox, Keith R

“…DNase I footprints of intermolecular DNA triplexes are often accompanied by enhanced cleavage at the 3′-end of the target site at the triplex–duplex junction…”
Get full text

2′-Aminoethoxy-2-amino-3-methylpyridine in Triplex-Forming Oligonucleotides: High Affinity, Selectivity and Resistance to Enzymatic Degradation by Lou, Chenguang, Shelbourne, Montserrat, Fox, Keith R., Brown, Tom

“…The phosphoramidite monomer of the C‐nucleoside 2′‐aminoethoxy‐2‐amino‐3‐methylpyridine (AE‐MAP) has been synthesized for the first time and incorporated into…”
Get full text

Michael J. Waring 9 November 1939 to 16 November 2019 by Fox, Keith R.

Get full text

CG base pair recognition within DNA triple helices by modified N-methylpyrrolo-dC nucleosides by Gerrard, Simon R, Edrees, Mastoura M, Bouamaied, Imenne, Fox, Keith R, Brown, Tom

“…3-Aminophenyl-modified analogues of the bicyclic nucleoside N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one were synthesised and incorporated directly into…”
Get more information

Kinetic Stability of Intermolecular DNA Quadruplexes by Merkina, Elena E., Fox, Keith R.

“…Fluorescently labeled oligodeoxyribonucleotides containing a single tract of four successive guanines have been used to study the thermodynamic and kinetic…”
Get full text

An extra dimension in nucleic acid sequence recognition by Fox, Keith R, Brown, Tom

“…Watson-Crick base pairing is a natural molecular recognition process that has been exploited in molecular biology and universally adopted in many fields. An…”
Get more information

Editorial: Preprints, citations and Nucleic Acids Research by Stoddard, Barry L, Fox, Keith R

Get full text

Potent Triple Helix Stabilization by 5',3'-Modified Triplex-Forming Oligonucleotides by Ben Gaied, Nouha, Zhao, Zhengyun, Gerrard, Simon R, Fox, Keith R, Brown, Tom

“…Anthraquinone and pyrene analogues attached to the 3' and/or 5' termini of triplex-forming oligonucleotides (TFOs) by various linkers increased the stability…”
Get full text

Melting temperature measurement and mesoscopic evaluation of single, double and triple DNA mismatches by Oliveira, Luciana M, Long, Adam S, Brown, Tom, Fox, Keith R, Weber, Gerald

“…Unlike the canonical base pairs AT and GC, the molecular properties of mismatches such as hydrogen bonding and stacking interactions are strongly dependent on…”
Get full text

Synthesis and properties of triplex-forming oligonucleotides containing 2′- O-(2-methoxyethyl)-5-(3-aminoprop-1-ynyl)-uridine by Lou, Chenguang, Xiao, Qiang, Brennan, Lavinia, Light, Mark E, Vergara-Irigaray, Nuria, Atkinson, Elizabeth M., Holden-Dye, Lindy M., Fox, Keith R., Brown, Tom

“…MEPU was synthesized and incorporated into TFOs which formed very stable triplexes with target duplexes. 2′- O-(2-Methoxyethyl)-5-(3-aminoprop-1-ynyl)-uridine…”
Get full text