Search Results - "Fox, Edward J."

Detection of ultra-rare mutations by next-generation sequencing by Schmitt, Michael W, Kennedy, Scott R, Salk, Jesse J, Fox, Edward J, Hiatt, Joseph B, Loeb, Lawrence A

“…Next-generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate…”
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Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial by Coles, Alasdair J, Dr, Twyman, Cary L, MD, Arnold, Douglas L, Prof, Cohen, Jeffrey A, Prof, Confavreux, Christian, Prof, Fox, Edward J, MD, Hartung, Hans-Peter, Prof, Havrdova, Eva, Prof, Selmaj, Krzysztof W, Prof, Weiner, Howard L, Prof, Miller, Tamara, MD, Fisher, Elizabeth, PhD, Sandbrink, Rupert, MD, Lake, Stephen L, ScD, Margolin, David H, MD, Oyuela, Pedro, MD, Panzara, Michael A, MD, Compston, D Alastair S, Prof

“…Summary Background The anti-CD52 monoclonal antibody alemtuzumab reduces disease activity in previously untreated patients with relapsing-remitting multiple…”
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Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial by Cohen, Jeffrey A, Prof, Coles, Alasdair J, PhD, Arnold, Douglas L, Prof, Confavreux, Christian, Prof, Fox, Edward J, MD, Hartung, Hans-Peter, Prof, Havrdova, Eva, Prof, Selmaj, Krzysztof W, Prof, Weiner, Howard L, Prof, Fisher, Elizabeth, PhD, Brinar, Vesna V, MD, Giovannoni, Gavin, Prof, Stojanovic, Miroslav, MD, Ertik, Bella I, MD, Lake, Stephen L, ScD, Margolin, David H, MD, Panzara, Michael A, MD, Compston, D Alastair S, Prof

“…Summary Background The anti-CD52 monoclonal antibody alemtuzumab reduced disease activity in a phase 2 trial of previously untreated patients with…”
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How Does Assortment Affect Grocery Store Choice? by Briesch, Richard A., Chintagunta, Pradeep K., Fox, Edward J.

“…The authors investigate the impact of product assortments, along with convenience, prices, and feature advertising, on consumers' grocery store choice…”
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Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations by Itsara, Leslie S, Kennedy, Scott R, Fox, Edward J, Yu, Selina, Hewitt, Joshua J, Sanchez-Contreras, Monica, Cardozo-Pelaez, Fernando, Pallanck, Leo J

“…The accumulation of somatic mitochondrial DNA (mtDNA) mutations is implicated in aging and common diseases of the elderly, including cancer and…”
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Mutational heterogeneity in human cancers: origin and consequences by Salk, Jesse J, Fox, Edward J, Loeb, Lawrence A

“…Cancer recapitulates Darwinian evolution. Mutations acquired during life that provide cells with a growth or survival advantage will preferentially multiply to…”
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Brain proteomic analysis implicates actin filament processes and injury response in resilience to Alzheimer’s disease by Huang, Zhi, Merrihew, Gennifer E., Larson, Eric B., Park, Jea, Plubell, Deanna, Fox, Edward J., Montine, Kathleen S., Latimer, Caitlin S., Dirk Keene, C., Zou, James Y., MacCoss, Michael J., Montine, Thomas J.

“…Resilience to Alzheimer’s disease is an uncommon combination of high disease burden without dementia that offers valuable insights into limiting clinical…”
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Whole genome deconvolution unveils Alzheimer’s resilient epigenetic signature by Berson, Eloise, Sreenivas, Anjali, Phongpreecha, Thanaphong, Perna, Amalia, Grandi, Fiorella C., Xue, Lei, Ravindra, Neal G., Payrovnaziri, Neelufar, Mataraso, Samson, Kim, Yeasul, Espinosa, Camilo, Chang, Alan L., Becker, Martin, Montine, Kathleen S., Fox, Edward J., Chang, Howard Y., Corces, M. Ryan, Aghaeepour, Nima, Montine, Thomas J.

“…Assay for Transposase Accessible Chromatin by sequencing (ATAC-seq) accurately depicts the chromatin regulatory state and altered mechanisms guiding gene…”
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Lethal Mutagenesis: Targeting the Mutator Phenotype in Cancer by Fox, Edward J, Loeb, Lawrence A

“…Abstract The evolution of cancer and RNA viruses share many similarities. Both exploit high levels of genotypic diversity to enable extensive phenotypic…”
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dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants by Williams, Lindsey N., Marjavaara, Lisette, Knowels, Gary M., Schultz, Eric M., Fox, Edward J., Chabes, Andrei, Herr, Alan J.

“…Significance An increased rate of mutation, or “mutator phenotype,” generates genetic diversity that can accelerate cancer progression or confer resistance to…”
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Impact of Comorbidities on Hospitalization Costs Following Hip Fracture by Nikkel, Lucas E, Fox, Edward J, Black, Kevin P, Davis, Charles, Andersen, Lucille, Hollenbeak, Christopher S

“…BACKGROUND:Hip fractures are common in the elderly, and patients with hip fractures frequently have comorbid illnesses. Little is known about the relationship…”
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Mass synaptometry: High-dimensional multi parametric assay for single synapses by Gajera, Chandresh R., Fernandez, Rosemary, Postupna, Nadia, Montine, Kathleen S., Fox, Edward J., Tebaykin, Dmitry, Angelo, Michael, Bendall, Sean C., Keene, C. Dirk, Montine, Thomas J.

“…•Mass synaptometry method for single synapse multiplexed molecular profiling.•Synapse by Time Of Flight (SynTOF) panel of 34 antibodies for wide…”
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Why is Assortment Planning so Difficult for Retailers? A Framework and Research Agenda by Mantrala, Murali K., Levy, Michael, Kahn, Barbara E., Fox, Edward J., Gaidarev, Peter, Dankworth, Bill, Shah, Denish

“…When retailers conduct product assortment planning (PAP), they determine (1) The variety of merchandise, (2) The depth of merchandise, and (3) Service level or…”
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Cross-species comparative analysis of single presynapses by Berson, Eloïse, Gajera, Chandresh R., Phongpreecha, Thanaphong, Perna, Amalia, Bukhari, Syed A., Becker, Martin, Chang, Alan L., De Francesco, Davide, Espinosa, Camilo, Ravindra, Neal G., Postupna, Nadia, Latimer, Caitlin S., Shively, Carol A., Register, Thomas C., Craft, Suzanne, Montine, Kathleen S., Fox, Edward J., Keene, C. Dirk, Bendall, Sean C., Aghaeepour, Nima, Montine, Thomas J.

“…Comparing brain structure across species and regions enables key functional insights. Leveraging publicly available data from a novel mass cytometry-based…”
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Heparin-enriched plasma proteome is significantly altered in Alzheimer's disease by Guo, Qi, Ping, Lingyan, Dammer, Eric B, Duong, Duc M, Yin, Luming, Xu, Kaiming, Shantaraman, Anantharaman, Fox, Edward J, Golde, Todd E, Johnson, Erik C B, Roberts, Blaine R, Lah, James J, Levey, Allan I, Seyfried, Nicholas T

“…Heparin binding proteins (HBPs) with roles in extracellular matrix assembly are strongly correlated to β-amyloid (Aβ) and tau pathology in Alzheimer's disease…”
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Risk of Fractures After Renal Transplantation in the United States by NIKKEL, Lucas E, HOLLENBEAK, Christopher S, FOX, Edward J, UEMURA, Tadahiro, GHAHRAMANI, Nasrollah

“…Although it is known that the incidence of fracture events is increased in renal transplantation recipients, the timing and the factors associated with risk of…”
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Improvements in no evidence of disease activity with ublituximab vs. teriflunomide in the ULTIMATE phase 3 studies in relapsing multiple sclerosis by Alvarez, Enrique, Steinman, Lawrence, Fox, Edward J., Hartung, Hans-Peter, Qian, Peiqing, Wray, Sibyl, Robertson, Derrick, Selmaj, Krzysztof, Wynn, Daniel, Mok, Koby, Xu, Yihuan, Bodhinathan, Karthik, Miskin, Hari P., Cree, Bruce A. C.

“…Background Ublituximab is a novel anti-CD20 monoclonal antibody glycoengineered for enhanced antibody-dependent cellular cytotoxicity. The phase 3 ULTIMATE I…”
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Detection of Ultra-Rare Mitochondrial Mutations in Breast Stem Cells by Duplex Sequencing by Ahn, Eun Hyun, Hirohata, Kensen, Kohrn, Brendan F, Fox, Edward J, Chang, Chia-Cheng, Loeb, Lawrence A

“…Long-lived adult stem cells could accumulate non-repaired DNA damage or mutations that increase the risk of tumor formation. To date, studies on mutations in…”
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Category Positioning and Store Choice: The Role of Destination Categories by Briesch, Richard A., Dillon, William R., Fox, Edward J.

“…We focus on destination categories, so named because they have the greatest impact on where households choose to shop and, more generally, on how category…”
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A Rapid Assay for Measuring Nucleotide Excision Repair by Oligonucleotide Retrieval by Shen, Jiang-Cheng, Fox, Edward J., Ahn, Eun Hyun, Loeb, Lawrence A.

“…Nucleotide excision repair (NER) excises bulky DNA lesions induced by mutagens and carcinogens. The repair process includes recognition of DNA damage, excision…”
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