Search Results - "Fox, Donald T"

Polyploidization and Cell Fusion Contribute to Wound Healing in the Adult Drosophila Epithelium by Losick, Vicki P., Fox, Donald T., Spradling, Allan C.

“…Reestablishing epithelial integrity and biosynthetic capacity is critically important following tissue damage. The adult Drosophila abdominal epithelium…”
Get full text

Drosophila Stem Cell Niches: A Decade of Discovery Suggests a Unified View of Stem Cell Regulation by Losick, Vicki P., Morris, Lucy X., Fox, Donald T., Spradling, Allan

“…The past decade of research on Drosophila stem cells and niches has provided key insights. Fly stem cells do not occupy a special “state” based on novel “stem…”
Get full text

Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2 by Bretscher, Heidi S., Fox, Donald T.

“…Conserved DNA-damage responses (DDRs) sense genome damage and prevent mitosis of broken chromosomes. How cells lacking DDRs cope with broken chromosomes during…”
Get full text

Orb2 enables rare-codon-enriched mRNA expression during Drosophila neuron differentiation by Stewart, Rebeccah K., Nguyen, Patrick, Laederach, Alain, Volkan, Pelin C., Sawyer, Jessica K., Fox, Donald T.

“…Regulation of codon optimality is an increasingly appreciated layer of cell- and tissue-specific protein expression control. Here, we use codon-modified…”
Get full text

Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut by Cohen, Erez, Allen, Scott R, Sawyer, Jessica K, Fox, Donald T

“…Ploidy-increasing cell cycles drive tissue growth in many developing organs. Such cycles, including endocycles, are increasingly appreciated to drive tissue…”
Get full text

Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila by Fox, Donald T, Peifer, Mark

“…Morphogenesis involves the interplay of different cytoskeletal regulators. Investigating how they interact during a given morphogenetic event will help us…”
Get full text

Toxicological Study and Genetic Basis of BTEX Susceptibility in Drosophila melanogaster by Adebambo, Temitope H., Fox, Donald T., Otitoloju, Adebayo A.

“…Benzene, toluene, ethylbenzene and xylene, also known as BTEX, are released into environmental media by petroleum product exploratory and exploitative…”
Get full text

The Drosophila Hindgut Lacks Constitutively Active Adult Stem Cells but Proliferates in Response to Tissue Damage by Fox, Donald T., Spradling, Allan C.

“…The adult Drosophila hindgut was recently reported to contain active, tissue-replenishing stem cells, like those of the midgut, but located within an anterior…”
Get full text

Distinct responses to rare codons in select Drosophila tissues by Allen, Scott R, Stewart, Rebeccah K, Rogers, Michael, Ruiz, Ivan Jimenez, Cohen, Erez, Laederach, Alain, Counter, Christopher M, Sawyer, Jessica K, Fox, Donald T

“…Codon usage bias has long been appreciated to influence protein production. Yet, relatively few studies have analyzed the impacts of codon usage on…”
Get full text

Exploiting codon usage identifies intensity-specific modifiers of Ras/MAPK signaling in vivo by Sawyer, Jessica K, Kabiri, Zahra, Montague, Ruth A, Allen, Scott R, Stewart, Rebeccah, Paramore, Sarah V, Cohen, Erez, Zaribafzadeh, Hamed, Counter, Christopher M, Fox, Donald T

“…Signal transduction pathways are intricately fine-tuned to accomplish diverse biological processes. An example is the conserved…”
Get full text

Distinct responses to reduplicated chromosomes require distinct Mad2 responses by Stormo, Benjamin M, Fox, Donald T

“…Duplicating chromosomes once each cell cycle produces sister chromatid pairs, which separate accurately at anaphase. In contrast, reduplicating chromosomes…”
Get full text

Cytoplasmic sharing through apical membrane remodeling by Peterson, Nora G, Stormo, Benjamin M, Schoenfelder, Kevin P, King, Juliet S, Lee, Rayson Rs, Fox, Donald T

“…Multiple nuclei sharing a common cytoplasm are found in diverse tissues, organisms, and diseases. Yet, multinucleation remains a poorly understood biological…”
Get full text

The expanding implications of polyploidy by Schoenfelder, Kevin P, Fox, Donald T

“…Polyploid cells, which contain more than two genome copies, occur throughout nature. Beyond well-established roles in increasing cell size/metabolic output,…”
Get full text

Endoreplication and polyploidy: insights into development and disease by Fox, Donald T, Duronio, Robert J

“…Polyploid cells have genomes that contain multiples of the typical diploid chromosome number and are found in many different organisms. Studies in a variety of…”
Get full text

Polyploidy: A Biological Force From Cells to Ecosystems by Fox, Donald T., Soltis, Douglas E., Soltis, Pamela S., Ashman, Tia-Lynn, Van de Peer, Yves

“…Polyploidy, resulting from the duplication of the entire genome of an organism or cell, greatly affects genes and genomes, cells and tissues, organisms, and…”
Get full text

Model systems for regeneration: Drosophila by Fox, Donald T, Cohen, Erez, Smith-Bolton, Rachel

“…has historically been a workhorse model organism for studying developmental biology. In addition, is an excellent model for studying how damaged tissues and…”
Get full text

Broken chromosomes heading into mitosis: More than one way to patch a flat tire by Messer, C Luke, Fox, Donald T

“…A cell dealing with a broken chromosome in mitosis is like a driver dealing with a flat tire on the highway: damage repair must occur under non-ideal…”
Get full text

Communal living: the role of polyploidy and syncytia in tissue biology by Peterson, Nora G., Fox, Donald T.

“…Multicellular organisms are composed of tissues with diverse cell sizes. Whether a tissue primarily consists of numerous, small cells as opposed to fewer,…”
Get full text

Accelerated cell cycles enable organ regeneration under developmental time constraints in the Drosophila hindgut by Cohen, Erez, Peterson, Nora G., Sawyer, Jessica K., Fox, Donald T.

“…Individual organ development must be temporally coordinated with development of the rest of the organism. As a result, cell division cycles in a developing…”
Get full text

Integrating the Study of Polyploidy Across Organisms, Tissues, and Disease by Morris, John P, Baslan, Timour, Soltis, Douglas E, Soltis, Pamela S, Fox, Donald T

“…Polyploidy is a cellular state containing more than two complete chromosome sets. It has largely been studied as a discrete phenomenon in either organismal,…”
Get full text