Search Results - "Fowlkes, John"

Diabetes pharmacotherapy and effects on the musculoskeletal system by Kalaitzoglou, Evangelia, Fowlkes, John L., Popescu, Iuliana, Thrailkill, Kathryn M.

“…Summary Persons with type 1 or type 2 diabetes have a significantly higher fracture risk than age‐matched persons without diabetes, attributed to…”
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RASopathies: The musculoskeletal consequences and their etiology and pathogenesis by Fowlkes, John L., Thrailkill, Kathryn M., Bunn, R. Clay

“…The RASopathies comprise an ever-growing number of clinical syndromes resulting from germline mutations in components of the RAS/MAPK signaling pathway. While…”
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Mouse models of type 1 diabetes and their use in skeletal research by Kalaitzoglou, Evangelia, Fowlkes, John L., Thrailkill, Kathryn M.

“…In this review, we describe the three primary mouse models of insulin-deficiency diabetes that have been used to study the effects of type 1 diabetes (T1D) on…”
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The impact of SGLT2 inhibitors, compared with insulin, on diabetic bone disease in a mouse model of type 1 diabetes by Thrailkill, Kathryn M., MD, Nyman, Jeffry S., PhD, Bunn, R. Clay, PhD, Uppuganti, Sasidhar, MS, Thompson, Katherine L., PhD, Lumpkin, Charles K., PhD, Kalaitzoglou, Evangelia, MD, Fowlkes, John L., MD

“…Abstract Skeletal co-morbidities in type 1 diabetes include an increased risk for fracture and delayed fracture healing, which are intertwined with disease…”
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Effects of Type 1 Diabetes on Osteoblasts, Osteocytes, and Osteoclasts by Kalaitzoglou, Evangelia, Popescu, Iuliana, Bunn, R. Clay, Fowlkes, John L., Thrailkill, Kathryn M.

“…Purpose of Review To describe the effects of type 1 diabetes on bone cells. Recent findings Type 1 diabetes (T1D) is associated with low bone mineral density,…”
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LCoRL Regulates Growth and Metabolism by Wyler, Steven C, Gahlot, Surbhi, Bideyan, Lara, Yip, Cecilia, Dushime, Jasmine, Chen, Bandy, Lee, Jenny J, Tinajero, Arely, Limboy, Chelsea, Bordash, Staci, Heaselgrave, Samuel R, Nguyen, Tammy-Nhu, Lee, Syann, Bookout, Angie, Lantier, Loise, Fowlkes, John L, You, Young-Jai, Fujikawa, Teppei, Elmquist, Joel K

“…Abstract Genome-wide association studies (GWAS) in humans and livestock have identified genes associated with metabolic traits. However, the causality of many…”
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Canagliflozin, an SGLT2 inhibitor, corrects glycemic dysregulation in TallyHO model of T2D but only partially prevents bone deficits by Thrailkill, Kathryn M., Bunn, R. Clay, Uppuganti, Sasidhar, Ray, Philip, Popescu, Iuliana, Kalaitzoglou, Evangelia, Fowlkes, John L., Nyman, Jeffry S.

“…Higher fracture risk in type 2 diabetes (T2D) is attributed to disease-specific deficits in micro-structural and material properties of bone, although the…”
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Impact of an SGLT2-loss of function mutation on renal architecture, histology, and glucose homeostasis by Hughes, Corey B., Mussman, George M., Ray, Phil, Bunn, Robert C., Cornea, Virgilius, Thrailkill, Kathryn M., Fowlkes, John L., Popescu, Iuliana

“…Inhibitors of sodium/glucose co-transporter 2 (SGLT2) are currently in clinical use for type 2 diabetes (T2D) treatment due to their anti-hyperglycemic effect…”
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Genetic ablation of SGLT2 function in mice impairs tissue mineral density but does not affect fracture resistance of bone by Thrailkill, Kathryn M., Bunn, R. Clay, Uppuganti, Sasidhar, Ray, Philip, Garrett, Kate, Popescu, Iuliana, Pennings, Jacquelyn S., Fowlkes, John L., Nyman, Jeffry S.

“…Selective sodium-dependent glucose co-transporter 2 inhibitors (SGLT2Is) are oral hypoglycemic medications utilized increasingly in the medical management of…”
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Enhanced Excretion of Vitamin D Binding Protein in Type 1 Diabetes: A Role in Vitamin D Deficiency? by Thrailkill, Kathryn M, Jo, Chan-Hee, Cockrell, Gael E, Moreau, Cynthia S, Fowlkes, John L

“…Context: Vitamin D deficiency is an increasingly recognized comorbidity in patients with both type 1 (T1D) and type 2 diabetes, particularly associated with…”
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Primary Care Cluster RCT to Increase Diabetes Prevention Program Referrals by Keck, James W., Roper, Karen L., Hieronymus, Laura B., Thomas, Alisha R., Huang, Zhengyuan, Westgate, Philip M., Fowlkes, John L., Cardarelli, Roberto

“…The Diabetes Prevention Program, an intensive lifestyle change program, effectively reduces the risk of progression from prediabetes to type 2 diabetes but is…”
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SGLT2 inhibitor therapy improves blood glucose but does not prevent diabetic bone disease in diabetic DBA/2J male mice by Thrailkill, Kathryn M, Clay Bunn, R, Nyman, Jeffry S, Rettiganti, Mallikarjuna R, Cockrell, Gael E, Wahl, Elizabeth C, Uppuganti, Sasidhar, Lumpkin, Charles K, Fowlkes, John L

“…Abstract Persons with type 1 and type 2 diabetes have increased fracture risk, attributed to deficits in the microarchitecture and strength of diabetic bone,…”
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Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues by Thrailkill, Kathryn M, Lumpkin, Jr, Charles K, Bunn, R Clay, Kemp, Stephen F, Fowlkes, John L

“…Diabetic osteoporosis is increasingly recognized as a significant comorbidity of type 1 diabetes mellitus. In contrast, type 2 diabetes mellitus is more…”
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Constitutive activation of MEK1 in osteoprogenitors increases strength of bone despite impairing mineralization by Fowlkes, John L., Bunn, R. Clay, Ray, Philip D., Kalaitzoglou, Evangelia, Uppuganti, Sasidhar, Unal, Mustafa, Nyman, Jeffry S., Thrailkill, Kathryn M.

“…•MEK1 activation in osteoprogenitors in mice resembles melorheostosis in humans.•Osteoidosis is a prominent feature of MEK1 activation in…”
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Heterogeneity and altered β-cell identity in the TallyHo model of early-onset type 2 diabetes by McDonald, Sarah, Ray, Phil, Bunn, Robert C., Fowlkes, John L., Thrailkill, Kathryn M., Popescu, Iuliana

“…A primary underlying defect makes β-cells "susceptible" to no longer compensate for the peripheral insulin resistance and to trigger the onset of type 2…”
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Matrix metalloproteinases: their potential role in the pathogenesis of diabetic nephropathy by Thrailkill, Kathryn M., Clay Bunn, R., Fowlkes, John L.

“…Matrix metalloproteinases (MMPs), a family of proteinases including collagenases, gelatinases, stromelysins, matrilysins, and membrane-type MMPs, affect the…”
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Palmitate and insulin synergistically induce IL-6 expression in human monocytes by Bunn, Robert C, Cockrell, Gael E, Ou, Yang, Thrailkill, Kathryn M, Lumpkin, Jr, Charles K, Fowlkes, John L

“…Insulin resistance is associated with a proinflammatory state that promotes the development of complications such as type 2 diabetes mellitus (T2DM) and…”
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Emerging therapies for the treatment of rare pediatric bone disorders by Thrailkill, Kathryn M., Kalaitzoglou, Evangelia, Fowlkes, John L.

“…In recent years, new therapies for the treatment of rare pediatric bone disorders have emerged, guided by an increasing understanding of the genetic and…”
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Postnatal loss of the insulin receptor in osteoprogenitor cells does not impart a metabolic phenotype by Fowlkes, John L., Clay Bunn, R., Kalaitzoglou, Evangelia, Ray, Phil, Popescu, Iuliana, Thrailkill, Kathryn M.

“…The relationship between osteoblast-specific insulin signaling, osteocalcin activation and gluco-metabolic homeostasis has proven to be complex and potentially…”
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Biomechanical Stimulation of Muscle Constructs Influences Phenotype of Bone Constructs by Modulating Myokine Secretion by Suresh Kumar, Harshini, Barnett, Edwina N., Fowlkes, John L., Kalaitzoglou, Evangelia, Annamalai, Ramkumar T.

“…ABSTRACT Diabetes is a chronic metabolic disorder that can lead to diabetic myopathy and bone diseases. The etiology of musculoskeletal complications in such…”
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