Search Results - "Fowler, Melissa A"

Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain by Fowler, Melissa A, Sidiropoulou, Kyriaki, Ozkan, Emin D, Phillips, Christopher W, Cooper, Donald C

“…The canonical transient receptor potential (TRPC) channels are a family of non-selective cation channels that are activated by increases in intracellular…”
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Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity by Sidiropoulou, Kyriaki, White, Francis J, Lu, Fang-Min, Cooper, Donald C, Xiao, Rui, Ozkan, Emin D, Phillips, Christopher, Fowler, Melissa A, Zhu, Michael X

“…Individual prefrontal cortex neurons can exhibit persistent activity during a delay between a cue and a behavioral response. Here the authors report on an…”
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Drosophila TRP channels and animal behavior by Fowler, Melissa A., Montell, Craig

“…Multiple classes of cell surface receptors and ion channels participate in the detection of changes in environmental stimuli, and thereby influence animal…”
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Discovery of CRN04894: A Novel Potent Selective MC2R Antagonist by Kim, Sun Hee, Han, Sangdon, Zhao, Jian, Wang, Shimiao, Kusnetzow, Ana Karin, Reinhart, Greg, Fowler, Melissa A., Markison, Stacy, Johns, Michael, Luo, Rosa, Struthers, R. Scott, Zhu, Yunfei, Betz, Stephen F.

“…A novel class of nonpeptide melanocortin type 2 receptor (MC2R) antagonists was discovered through modification of known nonpeptide MC4R ligands…”
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Parenting skills and family support programs for drug-abusing mothers by Kumpfer, Karol L, Fowler, Melissa A

“…Summary Children born to drug-using mothers can suffer from fetal alcohol or drug syndrome (FAS/FDS) or fetal alcohol or drug effect (FAE/FDE). Such children…”
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A role for the subiculum in the brain motivation/reward circuitry by Cooper, Donald C., Klipec, William D., Fowler, Melissa A., Ozkan, Emin D.

“…The ventral subiculum (vSUB) is an interface between the hippocampal formation and structures in the brain reward circuitry, such as the nucleus accumbens…”
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FRI538 Discovery And Characterization Of Orally Bioavailable Nonpeptide Thyroid Stimulating Hormone Receptor (TSHR) Antagonists For The Treatment Of Graves’ Disease by Fowler, Melissa A, Regan, Collin, Zhao, Jian, Coutinho, Eulalia, Fleck, Beth, Castellanos, Anel A, Muller, Eric, Johns, Michael, Tang, Yang, Sturchler, Emmanuel, Chen, Mi, Retting, Kelsey, Dalvie, Deepak, Betz, Stephen F, Markison, Stacy

“…Disclosure: M.A. Fowler: Employee; Self; Crinetics Pharmaceuticals. Stock Owner; Self; Crinetics Pharmaceuticals. C. Regan: Employee; Self; Crinetics…”
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SAT182 Effects Of An Orally Bioavailable Nonpeptide Parathyroid Hormone Receptor Type 1 (PTH1R) Antagonist In Rodent Models Of Primary Hyperparathyroidism (PHPT) by Antwan, Agnes S, Rico-Bautista, Elizabeth, Pontillo, Joe, Wang, Shimiao, Johns, Michael, Ramms, Bastian, Fowler, Melissa A, Nguyen, Julie B, Castellanos Gonzalez, Anel A, Fleck, Beth, Retting, Kelsey, Dalvie, Deepak, Betz, Stephen F, Markison, Stacy

“…Disclosure: A.S. Antwan: Employee; Self; Crinetics Pharmaceuticals. E. Rico-Bautista: Employee; Self; Crinetics Pharmaceuticals. J. Pontillo: Employee; Self;…”
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LBSAT142 Discovery And Characterization Of A Potent And Orally Bioavailable Parathyroid Hormone Receptor Type-1 (PTHR1) Antagonist For The Treatment Of Hypercalcemia by Rico-Bautista, Elizabeth, Pontillo, Joseph, Wang, Shimiao, Antwan, Agnes S, Arroyo, Pablo, Fleck, Beth, Fowler, Melissa A, Reinhart, Greg, Johns, Michael A, Kusnetzow, Ana K, Zhu, Yun Fei, Markison, Stacy, Betz, Stephen F

“…Hypercalcemia is a common disorder defined as a serum calcium concentration higher than the normal range of 8.5 - 10.5 mg/dL. The most common causes of…”
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Effects of CRN04894, a Nonpeptide Orally Bioavailable ACTH Antagonist, on Corticosterone in Rodent Models of ACTH Excess by Fowler, Melissa A, Kusnetzow, Ana Karin, Han, Sangdon, Reinhart, Greg, Kim, Sun Hee, Johns, Michael, Kredel, Taylor A, Antwan, Agnes, Athanacio, Jon, Tsivkovski, Oleg, Luo, Rosa, Madan, Ajay, Zhu, Yun Fei, Betz, Stephen F, Struthers, Scott, Markison, Stacy

“…CRN04894 is an orally administered nonpeptide that is a potent and selective antagonist for adrenocorticotropic hormone (ACTH) acting at the melanocortin 2…”
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OR19-03 Effects of Nonpeptide Orally Bioavailable ACTH Antagonists on Adrenal Gland Size and Function in Rats by Markison, Stacy, Fowler, Melissa A, Athanacio, Jon, Kredel, Taylor A, Antwan, Agnes, Johns, Michael, Tsivkovski, Oleg, Cruz, Shirley, Luo, Rosa, Reinhart, Greg, Kusnetzow, Ana Karin, Madan, Ajay, Betz, Stephen F, Struthers, Scott

“…Cushing’s disease (CD) and Ectopic ACTH syndrome (EAS) stem from excess circulating adrenocorticotropic hormone (ACTH) and resulting hypercortisolemia. In CD,…”
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MON-089 Discovery and Identification of Late Stage Selective Nonpeptide Somatostatin Subtype 5 (sst5) Agonists for the Treatment of Hyperinsulinemic Hypoglycemia by Fowler, Melissa A, Zhao, Jian, Sturchler, Emmanuel, Rico, Elizabeth, de Necochea-Campion, Rosalia, Athanacio, Jon, Kredel, Taylor A, Antwan, Agnes, Johns, Michael, Tsivkovski, Oleg, Wang, Shmiao, Luo, Rosa, Kusnetzow, Ana Karin, Madan, Ajay, Struthers, Scott, Markison, Stacy, Zhu, Yun Fei, Betz, Stephen F

“…Congenital hyperinsulinism (CHI) results from mutations within the insulin secretion pathway and is characterized by excessive and/or inappropriate insulin…”
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MON-176 Discovery and Identification of Late Stage Selective Nonpeptide ACTH Antagonists for the Treatment of Cushing’s Disease, Ectopic ACTH Secreting Tumors, and Congenital Adrenal Hyperplasia by Kusnetzow, Ana Karin, Han, Sangdon, Fowler, Melissa A, Athanacio, Jon, Reinhart, Greg, Rico, Elizabeth, Kim, Sun Hee, Johns, Michael, Kredel, Taylor A, Antwan, Agnes, Tsivkovski, Oleg, Nguyen, Julie, Staley, Christine, Tan, Hannah, Luo, Rosa, Markison, Stacy, Madan, Ajay, Zhu, Yun Fei, Struthers, Scott, Betz, Stephen F

“…Adrenocorticotropic hormone (ACTH) is an important modulator of steroidal hormone synthesis and secretion from the adrenal gland and its selective activity at…”
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Dopamine modulates an mGIuR5-mediated depolarization underlying prefrontal persistent activity by Sidiropoulou, Kyriaki, Lue, Fang-Min, Fowler, Melissa A, Xiao, Rui, Phillips, Christopher, Ozkan, Emin D, Zhu, Michael X, White, Francis J, Cooper, Donald C

“…The intrinsic properties of neurons that enable them to maintain depolarized, persistently activated states in the absence of sustained input are poorly…”
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Dopamine modulates an intrinsic mGluR5-mediated depolarization underlying prefrontal persistent activity by Sidiropoulou, Kyriaki, Lu, Fang-Min, Fowler, Melissa A., Xiao, Rui, Phillips, Christopher, Ozkan, Emin D., Zhu, Michael X., White, Francis J., Cooper, Donald C.

“…Intrinsic properties of neurons that enable them to maintain depolarized, persistently activated states in the absence of sustained input are poorly…”
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A role for the subiculum in the brain motivation/reward circuitry: The mammalian subiculum: Contrasting and complementary in vivo and in vitro approaches to subicular function by COOPER, Donald C, KLIPEC, William D, FOWLER, Melissa A, OZKAN, Emin D

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mGluR5 Knockout mice exhibit normal conditioned place-preference to cocaine by Fowler, Melissa A, Varnell, Andrew L, Cooper, Donald C

“…Metabotropic glutamate receptor 5 (mGluR5) null mutant (-/-) mice have been reported to totally lack the rein- forcing or locomotor stimulating effects of…”
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