Search Results - "Fowler, Jack F."

The radiobiology of prostate cancer including new aspects of fractionated radiotherapy by Fowler, Jack F

“…Total radiation dose is not a reliable measure of biological effect when dose-per-fraction or dose-rate is changed. Large differences in biological…”
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Stereotactic hypofractionated accurate radiotherapy of the prostate (SHARP), 33.5 Gy in five fractions for localized disease: First clinical trial results by Madsen, Berit L., M.D, Hsi, R. Alex, M.D, Pham, Huong T., M.D, Fowler, Jack F., D.Sc., Ph.D, Esagui, Laura, C.M.D, Corman, John, M.D

“…Purpose: To evaluate the feasibility and toxicity of stereotactic hypofractionated accurate radiotherapy (SHARP) for localized prostate cancer. Methods and…”
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Sensitivity Analysis of Parameters in Linear-Quadratic Radiobiologic Modeling by Fowler, Jack F., D.Sc., Ph.D., FInstP

“…Purpose Radiobiologic modeling is increasingly used to estimate the effects of altered treatment plans, especially for dose escalation. The present article…”
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Linear Quadratics Is Alive and Well: In Regard to Park et al. (Int J Radiat Oncol Biol Phys 2008;70:847–852) by Fowler, Jack F., D.Sc., Ph.D., F.Inst.P

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A challenge to traditional radiation oncology by Fowler, Jack F, Tomé, Wolfgang A, Fenwick, John D, Mehta, Minesh P

“…To investigate and compare the biologically effective doses, equivalent doses in 2-Gy fractions, log tumor cells killed, and late effects that can be estimated…”
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Loss of biological effect in prolonged fraction delivery by Fowler, Jack F, Welsh, James S, Howard, Steven P

“…The decrease of biologic effect if delivery of dose fractions takes more than a few minutes has been occasionally recognized in the literature but has been…”
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Correction to Kasibhatla et al. How Much Radiation Is the Chemotherapy Worth in Advanced Head and Neck Cancer? ( Int J Radiat Oncol Biol Phys 2007;68:1491–1495) by Fowler, Jack F., D.Sc., Ph.D., F.R.C.R., F.A.C.R.O

“…Purpose To correct several elementary radiobiologic errors in the otherwise admirable article by Kasibhatla, Kirkpatrick, and Brizel (2007) on estimating the…”
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On cold spots in tumor subvolumes by Tomé, Wolfgang A., Fowler, Jack F.

“…Losses in tumor control are estimated for cold spots of various “sizes” and degrees of “cold dose.” This question is important in the context of intensity…”
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Red Shell: Defining a High-Risk Zone of Normal Tissue Damage in Stereotactic Body Radiation Therapy by Yang, Jun, Ph.D, Fowler, Jack F., D.Sc., Ph.D, Lamond, John P., M.D, Lanciano, Rachelle, M.D, Feng, Jing, M.Sc, Brady, Luther W., M.D

“…Purpose To define a volume of tissue just outside of the clinical target volume (CTV) or planning target volume (PTV) in stereotactic body radiation therapy…”
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Comment on “Magical Protons?” Editorial by Goitein ( Int J Radiat Oncol Biol Phys 2008;70:654–656) by Fowler, Jack F., D.Sc., Ph.D

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Acute radiation reactions in oral and pharyngeal mucosa: tolerable levels in altered fractionation schedules by Fowler, Jack F, Harari, Paul M, Leborgne, Felix, Leborgne, José H

“…Purpose:To investigate whether a predictive estimate can be obtained for a ‘tolerance level’ of acute oral and pharyngeal mucosal reactions in patients…”
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In Reply to Dr. Lee by Fowler, Jack F., D.Sc., Ph.D., F.Inst.P

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When Is a “BED” not a “BED”?—When It Is an EQD2: In Regard to Buyyounouski et al. ( Int J Radiat Oncol Biol Phys 2010;76:1297–1304) by Fowler, Jack F., D.Sc., Ph.D., F.I.P.E.M., F.Inst.P., F.R.C.R., F.A.C.R., F.A.S.T.R.O., F.A.A.P.M, Dale, Roger G., Ph.D., F.I.P.E.M., F.Inst.P., F.R.C.R. (Hon.)

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Isn't It Reasonable to Ask for Fraction Numbers? by Fowler, Jack F., D.Sc., Ph.D., F.Inst.P, F.R.C.R., F.A.C.R

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Is the α/β ratio for prostate tumours really low and does it vary with the level of risk at diagnosis? by Fowler, Jack F, Toma-Dasu, Iuliana, Dasu, Alexandru

“…To answer the questions: Is the α/β ratio (radiosensitivity to size of dose-per-fraction) really low enough to justify using a few large dose fractions instead…”
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Modeling the Contribution of Synchronous Chemotherapy to the Rate of Grade 3 and 4 Mucositis in Locally Advanced Squamous Cell Carcinoma of the Head and Neck by Hartley, Andrew, MRCP., FRCR, Sanghera, Paul, MRCP., FRCR, Glaholm, John, FRCP., FRCR, Fowler, Jack F., DSc., PhD., FRCR., FACRO

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Development of radiobiology for oncology-a personal view by Fowler, Jack F

“…When I came into radiotherapy in 1950, I was puzzled that some patients were treated to 3000 rads (cGy) in 3 weeks but others received 4000 in 5 or 6000 in 6…”
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The prospects for new treatments for prostate cancer by Fowler, Jack F, Chappell, Rick J, Ritter, Mark A

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What hypofractionated protocols should be tested for prostate cancer? by Fowler, Jack F, Ritter, Mark A, Chappell, Rick J, Brenner, David J

“…Recent analyses of clinical results have suggested that the fractionation sensitivity of prostate tumors is remarkably high; corresponding point estimates of…”
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A modelled comparison of prostate cancer control rates after high-dose-rate brachytherapy (3145 multicentre patients) combined with, or in contrast to, external-beam radiotherapy by Roberts, Stephen A, Miralbell, Raymond, Zubizarreta, Eduardo H, Fowler, Jack F, Hendry, Jolyon H

“…Abstract Background and purpose To analyse biochemical relapse-free-survival results for prostate cancer patients receiving combined external beam and…”
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