Search Results - "Fowler, Christopher J"

The Basal Pharmacology of Palmitoylethanolamide by Rankin, Linda, Fowler, Christopher J

“…Palmitoylethanolamide (PEA, -hexadecanoylethanolamide) is an endogenous compound belonging to the family of -acylethanolamines. PEA has anti-inflammatory and…”
Get full text

Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy by Gabrielsson, Linda, Mattsson, Sofia, Fowler, Christopher J.

“…Palmitoylethanolamide (PEA) has been suggested to have useful analgesic properties and to be devoid of unwanted effects. Here, we have examined critically this…”
Get full text

Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development by Hou, Lu, Rong, Jian, Haider, Ahmed, Ogasawara, Daisuke, Varlow, Cassis, Schafroth, Michael A, Mu, Linjing, Gan, Jiefeng, Xu, Hao, Fowler, Christopher J, Zhang, Ming-Rong, Vasdev, Neil, Ametamey, Simon, Cravatt, Benjamin F, Wang, Lu, Liang, Steven H

“…The endocannabinoid system (ECS) is involved in a wide range of biological functions and comprises cannabinoid receptors and enzymes responsible for…”
Get full text

A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis by Hernández-Torres, Gloria, Cipriano, Mariateresa, Hedén, Erika, Björklund, Emmelie, Canales, Ángeles, Zian, Debora, Feliú, Ana, Mecha, Miriam, Guaza, Carmen, Fowler, Christopher J., Ortega-Gutiérrez, Silvia, López-Rodríguez, María L.

“…Monoacylglycerol lipase (MAGL) is the enzyme responsible for the inactivation of the endocannabinoid 2‐arachidonoylglycerol (2‐AG). MAGL inhibitors show…”
Get full text

Exploring the association between cancer and cognitive impairment in the Australian Imaging Biomarkers and Lifestyle (AIBL) study by Ma, Liwei, Low, Yi Ling Clare, Zhuo, Yuanhao, Chu, Chenyin, Wang, Yihan, Fowler, Christopher J., Tan, Edwin C. K., Masters, Colin L., Jin, Liang, Pan, Yijun

“…An inverse association between cancer and Alzheimer’s disease (AD) has been demonstrated; however, the association between cancer and mild cognitive impairment…”
Get full text

Cannabidiol improves vasorelaxation in Zucker diabetic fatty rats through cyclooxygenase activation by Wheal, Amanda J, Cipriano, Mariateresa, Fowler, Christopher J, Randall, Michael D, O'Sullivan, Saoirse Elizabeth

“…Cannabidiol (CBD) decreases insulitis, inflammation, neuropathic pain, and myocardial dysfunction in preclinical models of diabetes. We recently showed that…”
Get more information

Association of TPH1 and serotonin transporter genotypes with treatment response for suicidal ideation: a preliminary study by Nielsen, David A., Deng, Huiqiong, Patriquin, Michelle A., Harding, Mark J., Oldham, John, Salas, Ramiro, Fowler, J. Christopher, Frueh, B. Christopher

“…Variants in three genes coding for components of the serotonergic system, the tryptophan hydroxylase 1 ( TPH1 ) rs1799913, serotonin transporter ( SLC6A4 ) 5-…”
Get full text

Inhibition of endocannabinoid metabolism by the metabolites of ibuprofen and flurbiprofen by Karlsson, Jessica, Fowler, Christopher J

“…In addition to their effects upon prostaglandin synthesis, the non-steroidal anti-inflammatory drugs ibuprofen and flurbiprofen inhibit the metabolism of the…”
Get full text

Effects of tumour necrosis factor α upon the metabolism of the endocannabinoid anandamide in prostate cancer cells by Karlsson, Jessica, Gouveia-Figueira, Sandra, Alhouayek, Mireille, Fowler, Christopher J

“…Tumour necrosis factor α (TNFα) is involved in the pathogenesis of prostate cancer, a disease where disturbances in the endocannabinoid system are seen. In the…”
Get full text

Systemic perturbations of the kynurenine pathway precede progression to dementia independently of amyloid-β by Cespedes, Marcela, Jacobs, Kelly R., Maruff, Paul, Rembach, Alan, Fowler, Christopher J., Trounson, Brett, Pertile, Kelly K., Rumble, Rebecca L., Rainey-Smithe, Stephanie R., Rowe, Christopher C., Villemagne, Victor L., Bourgeat, Pierrick, Lim, Chai K., Chatterjee, Pratishtha, Martins, Ralph N., Ittner, Arne, Masters, Colin L., Doecke, James D., Guillemin, Gilles J., Lovejoy, David B.

“…Increasing evidence suggests that kynurenine pathway (KP) dyshomeostasis may promote disease progression in dementia. Studies in Alzheimer's disease (AD)…”
Get full text

Modulation of the endocannabinoid system: Neuroprotection or neurotoxicity? by Fowler, Christopher J., Rojo, Maria Luisa, Rodriguez-Gaztelumendi, Antonio

“…There is now a large volume of data indicating that compounds activating cannabinoid CB 1 receptors, either directly or indirectly by preventing the breakdown…”
Get full text

The Potential of Inhibitors of Endocannabinoid Metabolism for Drug Development: A Critical Review by Fowler, Christopher J

“…The endocannabinoids anandamide and 2-arachidonoylglycerol are metabolised by both hydrolytic enzymes (primarily fatty acid amide hydrolase (FAAH) and…”
Get more information

Elecsys CSF biomarker immunoassays demonstrate concordance with amyloid-PET imaging by Doecke, James D, Ward, Larry, Burnham, Samantha C, Villemagne, Victor L, Li, Qiao-Xin, Collins, Steven, Fowler, Christopher J, Manuilova, Ekaterina, Widmann, Monika, Rainey-Smith, Stephanie R, Martins, Ralph N, Masters, Colin L

“…β-amyloid (Aβ) positron emission tomography (PET) imaging is currently the only Food and Drug Administration-approved method to support clinical diagnosis of…”
Get full text

Exploring the fatty acid amide hydrolase and cyclooxygenase inhibitory properties of novel amide derivatives of ibuprofen by Deplano, Alessandro, Karlsson, Jessica, Svensson, Mona, Moraca, Federica, Catalanotti, Bruno, Fowler, Christopher J., Onnis, Valentina

“…Inhibition of fatty acid amide hydrolase (FAAH) reduces the gastrointestinal damage produced by non-steroidal anti-inflammatory agents such as sulindac and…”
Get full text

The Structure of Personality Pathology: Both General ('g') and Specific ('s') Factors? by Sharp, Carla, Wright, Aidan G. C., Fowler, J. Christopher, Frueh, B. Christopher, Allen, Jon G., Oldham, John, Clark, Lee Anna

“…Recent editions of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5; American Psychiatric Association, 2013) conceptualize personality…”
Get full text

Transport of endocannabinoids across the plasma membrane and within the cell by Fowler, Christopher J.

“…Endocannabinoids are readily accumulated from the extracellular space by cells. Although their uptake properties have the appearance of a process of…”
Get full text

Changes in Proportions of Linoleic Acid-derived Oxylipins in Oral Lichen Planus by Gouveia-Figueira, Sandra, Danielsson, Karin, Fowler, Christopher J

“…Abstract is missing (Short communication)…”
Get full text

Association between cannabinoid CB₁ receptor expression and Akt signalling in prostate cancer by Cipriano, Mariateresa, Häggström, Jenny, Hammarsten, Peter, Fowler, Christopher J

“…In prostate cancer, tumour expression of cannabinoid CB₁ receptors is associated with a poor prognosis. One explanation for this association comes from…”
Get full text

Diagnostic performance of CSF biomarkers in a well-characterized Australian cohort of sporadic Creutzfeldt-Jakob disease by Senesi, Matteo, Lewis, Victoria, Varghese, Shiji, Stehmann, Christiane, McGlade, Amelia, Doecke, James D, Ellett, Laura, Sarros, Shannon, Fowler, Christopher J, Masters, Colin L, Li, Qiao-Xin, Collins, Steven J

“…The most frequently utilized biomarkers to support a pre-mortem clinical diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) include concentrations of the…”
Get full text

Serum levels of oxylipins in achilles tendinopathy: an exploratory study by Gouveia-Figueira, Sandra, Nording, Malin L, Gaida, Jamie E, Forsgren, Sture, Alfredson, Håkan, Fowler, Christopher J

“…Linoleic acid-derived oxidation products are found in experimental pain models. However, little is known about the levels of such oxylipins in human pain. In…”
Get full text