Search Results - "Fournier, Pierrick G.J."

The TGF-β Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone by Fournier, Pierrick G.J., Juárez, Patricia, Jiang, Guanglong, Clines, Gregory A., Niewolna, Maria, Kim, Hun Soo, Walton, Holly W., Peng, Xiang Hong, Liu, Yunlong, Mohammad, Khalid S., Wells, Clark D., Chirgwin, John M., Guise, Theresa A.

“…Transforming growth factor-β (TGF-β) regulates the expression of genes supporting breast cancer cells in bone, but little is known about prostate cancer bone…”
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Molecular Biology of Bone Metastasis by Kingsley, Lauren A, Fournier, Pierrick G J, Chirgwin, John M, Guise, Theresa A

“…Metastasis is a final stage of tumor progression. Breast and prostate cancer cells preferentially metastasize to bone, wherein they cause incurable osteolytic…”
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Bisphosphonates and cancer-induced bone disease : Beyond their antiresorptive activity by CLEZARDIN, Philippe, EBETINO, Frank H, FOURNIER, Pierrick G. J

“…Bisphosphonates are primarily known for their ability to inhibit osteoclast-mediated bone resorption. They are an indispensable part of therapy for patients…”
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Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vivo by Fournier, Pierrick G J, Daubiné, Florence, Lundy, Mark W, Rogers, Michael J, Ebetino, Frank H, Clézardin, Philippe

“…Bisphosphonates bind avidly to bone mineral and are potent inhibitors of osteoclast-mediated bone destruction. They also exhibit antitumor activity in vitro…”
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TGF-β-RI Kinase Inhibitor SD-208 Reduces the Development and Progression of Melanoma Bone Metastases by MOHAMMAD, Khalid S, JAVELAUD, Delphine, FOURNIER, Pierrick G. J, NIEWOLNA, Maria, RYAN MCKENNA, C, PENG, Xiang H, DUONG, Vu, DUNN, Lauren K, MAUVIEL, Alain, GUISE, Theresa A

“…Melanoma often metastasizes to bone where it is exposed to high concentrations of TGF-β. Constitutive Smad signaling occurs in human melanoma. Because TGF-β…”
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Bone Microenvironment‐Suppressed T Cells Increase Osteoclast Formation and Osteolytic Bone Metastases in Mice by Arellano, Danna L., Juárez, Patricia, Verdugo‐Meza, Andrea, Almeida‐Luna, Paloma S., Corral‐Avila, Juan A., Drescher, Florian, Olvera, Felipe, Jiménez, Samanta, Elzey, Bennett D., Guise, Theresa A., Fournier, Pierrick G.J.

“…ABSTRACT Immunotherapies use components of the immune system, such as T cells, to fight cancer cells, and are changing cancer treatment, causing durable…”
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Abstract 5812: Development of αVβ5 + exosomes for liver-targeted therapy by Montaño, Paloma Acosta, Félix, Eréndira Olvera, Flores, Verónica Castro, Juárez, Patricia, Fournier, Pierrick G.J.

“…Liver metastases are common in pancreatic and colorectal cancer. Their development is promoted by tumor-secreted exosomes that, thanks to the presence of the…”
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Abstract 5281: 5-Fluorouracil decreases MDSC and the development of osteolytic bone metastases from breast cancer in mice by Fournier, Pierrick G.J., Luna, Paloma Almeida, Arellano, Danna, Jiménez, Samanta, Olvera, Felipe, Juárez, Patricia

“…Bone metastases are a highly debilitating complication in more than 70% of patients with advanced breast and prostate cancer. Currently approved treatments…”
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Contribution of Macrophages and T Cells in Skeletal Metastasis by Mendoza-Reinoso, Veronica, McCauley, Laurie K, Fournier, Pierrick G J

“…Bone is a common site for metastases with a local microenvironment that is highly conducive for tumor establishment and growth. The bone marrow is replete with…”
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Abstract 4147: Chitosan luminescent rare-earth doped nanoparticles as cancer cell tracking for imaging tumors and their immune response by Osorio-Arciniega, Rodrigo, Lucero-Meza, Eduardo, Can-Uc, Bonifacio, Rocha-Mendoza, Israel, Fournier, Pierrick G.J., Hirata, Gustavo A, Juarez, Patricia

“…Background: Cancer is a group of diseases characterized by the unregulated growth of cells, which can be hard to diagnose due to the high false negatives or…”
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Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment by Dunn, Lauren K, Mohammad, Khalid S, Fournier, Pierrick G J, McKenna, C Ryan, Davis, Holly W, Niewolna, Maria, Peng, Xiang Hong, Chirgwin, John M, Guise, Theresa A

“…Most patients with advanced breast cancer develop bone metastases, which cause pain, hypercalcemia, fractures, nerve compression and paralysis. Chemotherapy…”
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Halofuginone inhibits TGF-β/BMP signaling and in combination with zoledronic acid enhances inhibition of breast cancer bone metastasis by Juárez, Patricia, Fournier, Pierrick G J, Mohammad, Khalid S, McKenna, Ryan C, Davis, Holly W, Peng, Xiang H, Niewolna, Maria, Mauviel, Alain, Chirgwin, John M, Guise, Theresa A

“…More efficient therapies that target multiple molecular mechanisms are needed for the treatment of incurable bone metastases. Halofuginone is a plant…”
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Development of a functionalized UV-emitting nanocomposite for the treatment of cancer using indirect photodynamic therapy by Sengar, Prakhar, Juárez, Patricia, Verdugo-Meza, Andrea, Arellano, Danna L, Jain, Akhil, Chauhan, Kanchan, Hirata, Gustavo A, Fournier, Pierrick G J

“…Photodynamic therapy is a promising cancer therapy modality but its application for deep-seated tumor is mainly hindered by the shallow penetration of visible…”
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Functionalized rare earth-doped nanoparticles for breast cancer nanodiagnostic using fluorescence and CT imaging by Jain, Akhil, Fournier, Pierrick G J, Mendoza-Lavaniegos, Vladimir, Sengar, Prakhar, Guerra-Olvera, Fernando M, Iñiguez, Enrique, Kretzschmar, Thomas G, Hirata, Gustavo A, Juárez, Patricia

“…Breast cancer is the second leading cause of cancer death among women and represents 14% of death in women around the world. The standard diagnosis method for…”
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Halofuginone Inhibits the Establishment and Progression of Melanoma Bone Metastases by JUAREZ, Patricia, MOHAMMAD, Khalid S, MAUVIEL, Alain, GUISE, Theresa A, JUAN JUAN YIN, FOURNIER, Pierrick G. J, MCKENNA, Ryan C, DAVIS, Holly W, PENG, Xiang H, NIEWOLNA, Maria, JAVELAUD, Delphine, CHIRGWIN, John M

“…TGF-β derived from bone fuels melanoma bone metastases by inducing tumor secretion of prometastatic factors that act on bone cells to change the skeletal…”
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The vitamin D receptor is involved in the regulation of human breast cancer cell growth via a ligand-independent function in cytoplasm by Trivedi, Trupti, Zheng, Yu, Fournier, Pierrick G J, Murthy, Sreemala, John, Sutha, Schillo, Suzanne, Dunstan, Colin R, Mohammad, Khalid S, Zhou, Hong, Seibel, Markus J, Guise, Theresa A

“…Vitamin D has pleiotropic effects on multiple tissues, including malignant tumors. Vitamin D inhibits breast cancer growth through activation of the vitamin D…”
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TIE2 Induces Breast Cancer Cell Dormancy and Inhibits the Development of Osteolytic Bone Metastases by Drescher, Florian, Juárez, Patricia, Arellano, Danna L, Serafín-Higuera, Nicolás, Olvera-Rodriguez, Felipe, Jiménez, Samanta, Licea-Navarro, Alexei F, Fournier, Pierrick Gj

“…Breast cancer (BCa) cells disseminating to the bone can remain dormant and resistant to treatments for many years until relapsing as bone metastases. The…”
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Monocytic Myeloid-Derived Suppressor Cells from Tumor Tissue Are a Differentiated Cell with Limited Fate Plasticity by Calvert, Ryan D, Fleet, James C, Fournier, Pierrick G J, Juarez, Patricia, Burcham, Grant N, Haverkamp, Jessica M, Guise, Theresa A, Ratliff, Timothy L, Elzey, Bennett D

“…Owing to ease of access and high yield, most murine myeloid-derived suppressor cell (MDSC) knowledge comes from the study of spleen-derived MDSCs rather than…”
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In silico-designed mutations increase variable new-antigen receptor single-domain antibodies for VEGF165 neutralization by Millán-Gómez, Dalia, Dueñas, Salvador, Muñoz, Patricia L.A., Camacho-Villegas, Tanya, Elosua, Carolina, Cabanillas-Bernal, Olivia, Escalante, Teresa, Perona, Almudena, Abia, David, Drescher, Florian, Fournier, Pierrick G.J., Ramos, Marco A., Mares, Rosa E., Paniagua-Solis, Jorge, Mata-Gonzalez, Teresa, Gonzalez-Canudas, Jorge, Hoffman, Robert M., Licea-Navarro, Alexei, Sánchez-Campos, Noemí

“…The stability, binding, and tissue penetration of variable new-antigen receptor (VNAR) single-domain antibodies have been tested as part of an investigation…”
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BMP7: A New B one M etastases P revention? by Fournier, Pierrick G.J, Guise, Theresa A

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