Alpha-fetoprotein is a biomarker of unfolded protein response and altered proteostasis in hepatocellular carcinoma cells exposed to sorafenib

Highlights • We examine the regulation of AFP production in HCC cells exposed to sorafenib. • Sorafenib inhibits the production of AFP independently of its effect on HCC cell viability. • Sorafenib activates the Unfolded Protein Response (UPR) in HCC cells. • The production of AFP reflects the impac...

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Bibliographic Details
Published in:	Cancer letters Vol. 370; no. 2; pp. 242 - 249
Main Authors:	Houessinon, Aline, Gicquel, Albane, Bochereau, Flora, Louandre, Christophe, Nyga, Rémy, Godin, Corinne, Degonville, James, Fournier, Emma, Saidak, Zuzana, Drullion, Claire, Barbare, Jean-Claude, Chauffert, Bruno, François, Catherine, Pluquet, Olivier, Galmiche, Antoine
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 28-01-2016 Elsevier Limited Elsevier
Subjects:	Alpha-fetoprotein alpha-Fetoproteins - analysis alpha-Fetoproteins - biosynthesis Antineoplastic Agents - pharmacology Biomarkers Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Cell Line, Tumor Cell Survival - drug effects DNA-Binding Proteins - physiology Gene expression Hematology, Oncology and Palliative Medicine Hepatocellular carcinoma Homeostasis Humans Kinases Life Sciences Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Niacinamide - analogs & derivatives Niacinamide - pharmacology Phenylurea Compounds - pharmacology Proteins Proteins - metabolism Proteostasis Regulatory Factor X Transcription Factors Signal transduction Sorafenib Studies Transcription factors Transcription Factors - physiology Unfolded Protein Response Unfolded Protein Response (UPR) Proteostasis GRP X-box binding protein 1 alpha-feto protein AFP PERK PKR-like ER kinase AREG eukaryotic translation initiation factor-2α Alpha-fetoprotein amphiregulin Unfolded Protein Response (UPR) RIDD eIF-2α UPR DFX VEGFR extracellular signal-regulated kinase 1/2 inositol-requiring enzyme-1α hepatocellular carcinoma glucose regulated protein XBP1 IRE-1α activating transcription factor-6 HCC regulated IRE-1α-dependent decay of mRNA unfolded protein response deferoxamine ERK1/2 Sorafenib vascular endothelial growth factor receptor ATF6 Hepatocellular carcinoma
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Summary:	Highlights • We examine the regulation of AFP production in HCC cells exposed to sorafenib. • Sorafenib inhibits the production of AFP independently of its effect on HCC cell viability. • Sorafenib activates the Unfolded Protein Response (UPR) in HCC cells. • The production of AFP reflects the impact of sorafenib on HCC cell proteostasis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2015.10.032