Search Results - "Fournet, Guy"

Monodisperse polysarcosine-based highly-loaded antibody-drug conjugates by Viricel, Warren, Fournet, Guy, Beaumel, Sabine, Perrial, Emeline, Papot, Sébastien, Dumontet, Charles, Joseph, Benoît

“…Antibody-drug conjugates (ADCs) convey highly potent anticancer drugs to antigen-expressing tumor cells, thereby sparing healthy tissues throughout the body…”
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Exatecan Antibody Drug Conjugates Based on a Hydrophilic Polysarcosine Drug-Linker Platform by Conilh, Louise, Fournet, Guy, Fourmaux, Eric, Murcia, Angélique, Matera, Eva-Laure, Joseph, Benoît, Dumontet, Charles, Viricel, Warren

“…We herein report the development and evaluation of a novel HER2-targeting antibody-drug conjugate (ADC) based on the topoisomerase I inhibitor payload…”
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Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer by Rebollido-Rios, Rocio, Venton, Geoffroy, Sánchez-Redondo, Sara, Iglesias i Felip, Carmela, Fournet, Guy, González, Elena, Romero Fernández, Wilber, Borroto Escuela, Dasiel Oscar, Di Stefano, Barbara, Penarroche-Díaz, Reinier, Martin, Guillaume, Ceylan, Ismail, Costello, Regis, Perez-Alea, Mileidys

“…Aldehyde dehydrogenases ( ALDHs ) are multifunctional enzymes that oxidize diverse endogenous and exogenous aldehydes. We conducted a meta-analysis based on…”
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Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes by Garcia-Lopez, Amparo, Tessaro, Francesca, Jonker, Hendrik R. A., Wacker, Anna, Richter, Christian, Comte, Arnaud, Berntenis, Nikolaos, Schmucki, Roland, Hatje, Klas, Petermann, Olivier, Chiriano, Gianpaolo, Perozzo, Remo, Sciarra, Daniel, Konieczny, Piotr, Faustino, Ignacio, Fournet, Guy, Orozco, Modesto, Artero, Ruben, Metzger, Friedrich, Ebeling, Martin, Goekjian, Peter, Joseph, Benoît, Schwalbe, Harald, Scapozza, Leonardo

“…Modification of SMN2 exon 7 (E7) splicing is a validated therapeutic strategy against spinal muscular atrophy (SMA). However, a target-based approach to…”
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Synthesis and biological evaluation of tetrahydro[1,4]diazepino[1,2-a]indol-1-ones as cyclin-dependent kinase inhibitors by Putey, Aurélien, Fournet, Guy, Lozach, Olivier, Perrin, Lionel, Meijer, Laurent, Joseph, Benoît

“…New series of 2,3,4,5-tetrahydro[1,4]diazepino[1,2-a]indol-1-ones and 3,4,5,10-tetrahydro-2H-diazepino[3,4-b]indol-1-ones have been synthesized through an…”
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Identifying Potent Nonsense-Mediated mRNA Decay Inhibitors with a Novel Screening System by Carrard, Julie, Ratajczak, Fiona, Elsens, Joséphine, Leroy, Catherine, Kong, Rebekah, Geoffroy, Lucie, Comte, Arnaud, Fournet, Guy, Joseph, Benoît, Li, Xiubin, Moebs-Sanchez, Sylvie, Lejeune, Fabrice

“…Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that degrades mRNAs carrying a premature termination codon. Its inhibition, alone or in…”
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Correction: Characterization of Transglutaminase 2 activity inhibitors in monocytes in vitro and their effect in a mouse model for multiple sclerosis by Chrobok, Navina L, Bol, John G J M, Jongenelen, Cornelis A, Brevé, John J P, El Alaoui, Said, Fidalgo-Lopez, Javier, Fournet, Guy, Joseph, Benoît, Wilhelmus, Micha M M, Drukarch, Benjamin, van Dam, Anne-Marie

“…[This corrects the article DOI: 10.1371/journal.pone.0196433.]…”
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Targeting Integrin-Dependent Adhesion and Signaling with 3-Arylquinoline and 3-Aryl-2-Quinolone Derivatives: A new Class of Integrin Antagonists by Fiorucci, Sandrine, Lin, Xiaochen, Sadoul, Karin, Fournet, Guy, Bouvard, Daniel, Vinogradova, Olga, Joseph, Benoît, Block, Marc R

“…We previously reported the anti-migratory function of 3-aryl-2-quinolone derivatives, chemically close to flavonoids (Joseph et al., 2002). Herein we show that…”
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N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine by Bettayeb, Karima, Sallam, Hatem, Ferandin, Yoan, Popowycz, Florence, Fournet, Guy, Hassan, Moustapha, Echalier, Aude, Bernard, Philippe, Endicott, Jane, Joseph, Benoît, Meijer, Laurent

“…Cyclin-dependent kinases (CDKs) and their regulators show frequent abnormalities in tumors. Ten low molecular weight pharmacologic inhibitors of CDKs are…”
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Monodisperse polysarcosine-based highly-loaded antibody-drug conjugatesElectronic supplementary information (ESI) available. See DOI: 10.1039/c9sc00285e by Viricel, Warren, Fournet, Guy, Beaumel, Sabine, Perrial, Emeline, Papot, Sébastien, Dumontet, Charles, Joseph, Benoît

“…Antibody-drug conjugates (ADCs) convey highly potent anticancer drugs to antigen-expressing tumor cells, thereby sparing healthy tissues throughout the body…”
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Monodisperse polysarcosine-based highly-loaded antibody-drug conjugates† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc00285e by Viricel, Warren, Fournet, Guy, Beaumel, Sabine, Perrial, Emeline, Papot, Sébastien, Dumontet, Charles, Joseph, Benoît

“…A new antibody-drug conjugate (ADC) chemical drug-linker platform based on polysarcosine enables increased drug-loading, improved pharmacokinetics and…”
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New 1-arylindoles based serotonin 5-HT7 antagonists. Synthesis and binding evaluation studies by Sagnes, Charlène, Fournet, Guy, Satala, Grzegorz, Bojarski, Andrzej J., Joseph, Benoît

“…Based on 5-HT1A and 5-HT7 ligand MR25003 scaffold, a new series of 1-aryl indole analogues were prepared and evaluated against 5-HT7 receptors. Modulations of…”
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Pyrazolo[1,5-a]-1,3,5-triazine as a Purine Bioisostere: Access to Potent Cyclin-Dependent Kinase Inhibitor (R)-Roscovitine Analogue by Popowycz, Florence, Fournet, Guy, Schneider, Cédric, Bettayeb, Karima, Ferandin, Yoan, Lamigeon, Cyrile, Tirado, Oscar M, Mateo-Lozano, Silvia, Notario, Vicente, Colas, Pierre, Bernard, Philippe, Meijer, Laurent, Joseph, Benoît

“…Pharmacological inhibitors of cyclin-dependent kinases (CDKs) have a wide therapeutic potential. Among the CDK inhibitors currently under clinical trials, the…”
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Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes by García López, Amparo, Tessaro, Francesca, Jonker, Hendrik R. A, Wacker, Anna, Richter, Christian, Comte, Arnaud, Berntenis, Nikolaos, Schmucki, Roland, Hatje, Klas, Petermann, Olivier, Chiriano, Gianpaolo, Perozzo, Remo, Sciarra, Daniel, Konieczny, Piotr, Faustino Pló, Ignacio, Fournet, Guy, Orozco López, Modesto, Artero, Ruben, Metzger, Friedrich, Ebeling, Martin, Goekjian, Peter, Joseph, Benoît, Schwalbe, Harald, Scapozza, Leonardo

“…Modification of SMN2 exon 7 (E7) splicing is a validated therapeutic strategy against spinal muscular atrophy (SMA). However, a target-based approach to…”
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New 1-arylindoles based serotonin 5-HT7 entagonists. Synthesis and binding evaluation studies by Sagnes, Charlène, Fournet, Guy, Satala, Grzegorz, Bojarski, Andrzej J., Joseph, Benoît

“…Based on 5-HT1A and 5-HT7 ligand MR25003 scaffold, a new series of 1-aryl indole analogues were prepared and evaluated against 5-HT7 receptors. Modulations of…”
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Novel competitive irreversible inhibitors of aldehyde dehydrogenase (ALDH1): restoration of chemosensitivity of L1210 cells overexpressing ALDH1 and induction of apoptosis in BAF3 cells overexpressing bcl2 by QUASH, Gerard, FOURNET, Guy, CHANTEPIE, Jacqueline, GORE, Jacques, ARDIET, Claude, ARDAIL, Dominique, MICHAL, Yvonne, REICHERTE, Uwe

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Inhibition of hepatitis C virus NS5B polymerase by S-trityl-l-cysteine derivatives by Nichols, Daniel B., Fournet, Guy, Gurukumar, K.R., Basu, Amartya, Lee, Jin-Ching, Sakamoto, Naoya, Kozielski, Frank, Musmuca, Ira, Joseph, Benoît, Ragno, Rino, Kaushik-Basu, Neerja

“…Structure-based studies led to the identification of a constrained derivative of S-trityl-l-cysteine (STLC) scaffold as a candidate inhibitor of hepatitis C…”
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Methionine-derived metabolites in apoptosis: therapeutic opportunities for inhibitors of their metabolism in chemoresistant cancer cells by Quash, Gérard, Fournet, Guy

“…Methionine, in addition to its role in protein synthesis, participates in 3 important cellular functions: as AdoMet in transmethylation; as…”
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Synthesis of 3-amino-5H-pyrrolo[2,3-e]-1,2,4-triazines by Sonogashira/copper(I)-catalyzed heteroannulation by Nyffenegger, Coralie, Fournet, Guy, Joseph, Benoît

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Synthesis of 3-amino-5 H-pyrrolo[2,3- e]-1,2,4-triazines by Sonogashira/copper(I)-catalyzed heteroannulation by Nyffenegger, Coralie, Fournet, Guy, Joseph, Benoît

“…A Sonogashira/copper(I)-catalyzed heteroannulation sequence was developed to convert 3,5-diamino-6-chloro-1,2,4-triazines to the corresponding 3-amino-5…”
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