Search Results - "Fountain, Samuel"

Update of P2X receptor properties and their pharmacology: IUPHAR Review 30 by Illes, Peter, Müller, Christa E., Jacobson, Kenneth A., Grutter, Thomas, Nicke, Annette, Fountain, Samuel J., Kennedy, Charles, Schmalzing, Günther, Jarvis, Michael F., Stojilkovic, Stanko S., King, Brian F., Di Virgilio, Francesco

“…The known seven mammalian receptor subunits (P2X1–7) form cationic channels gated by ATP. Three subunits compose a receptor channel. Each subunit is a…”
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P2X4 Receptor-Dependent Ca2+ Influx in Model Human Monocytes and Macrophages by Layhadi, Janice, Fountain, Samuel

“…Monocytes and macrophages express a repertoire of cell surface P2 receptors for adenosine 5′-triphosphate (ATP) a damage-associated molecular pattern molecule…”
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Action of MK‐7264 (gefapixant) at human P2X3 and P2X2/3 receptors and in vivo efficacy in models of sensitisation by Richards, David, Gever, Joel R., Ford, Anthony P., Fountain, Samuel J.

“…Background and Purpose The P2X3 receptor is an ATP‐gated ion channel expressed by sensory afferent neurons and is used as a target to treat chronic…”
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P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology by Stokes, Leanne, Layhadi, Janice A, Bibic, Lucka, Dhuna, Kshitija, Fountain, Samuel J

“…Adenosine 5'-triphosphate is a well-known extracellular signaling molecule and neurotransmitter known to activate purinergic P2X receptors. Information has…”
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ATP-Evoked Intracellular Ca2+ Responses in M-CSF Differentiated Human Monocyte-Derived Macrophage are Mediated by P2X4 and P2Y11 Receptor Activation by Layhadi, Janice A., Fountain, Samuel J.

“…Tissues differentially secrete multiple colony stimulating factors under conditions of homeostasis and inflammation, orientating recruited circulating…”
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Pharmacological differences between human and mouse P2X4 receptor explored using old and new tools by Fortuny-Gomez, Anna, Fountain, Samuel J.

“…There is growing interest in the P2X4 receptor as a therapeutic target for several cardiovascular, inflammatory and neurological conditions. Key to exploring…”
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Neuropeptide Y facilitates P2X1 receptor-dependent vasoconstriction via Y1 receptor activation in small mesenteric arteries during sympathetic neurogenic responses by Gonzalez-Montelongo, Maria del Carmen, Fountain, Samuel J.

“…ATP, norepinephrine and NPY are co-released by sympathetic nerves innervating arteries. ATP elicits vasoconstriction via activation of smooth muscle P2X…”
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Structural Basis of the Negative Allosteric Modulation of 5-BDBD at Human P2X4 Receptors by Bidula, Stefan, Nadzirin, Izzuddin Bin, Cominetti, Marco, Hickey, Harry, Cullum, Sean A, Searcey, Mark, Schmid, Ralf, Fountain, Samuel J

“…The P2X4 receptor is a ligand-gated ion channel activated by extracellular ATP. P2X4 activity is associated with neuropathic pain, vasodilation, and pulmonary…”
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STAT1‐ and NFAT‐independent amplification of purinoceptor function integrates cellular senescence with interleukin‐6 production in preadipocytes by Majeed, Yasser, Madani, Aisha Y., Altamimi, Ahmed I., Courjaret, Raphael, Vakayil, Muneera, Fountain, Samuel J., Machaca, Khaled, Mazloum, Nayef A.

“…Background and Purpose Senescent preadipocytes promote adipose tissue dysfunction by secreting pro‐inflammatory factors, although little is known about the…”
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Inhibitors of DAG metabolism suppress CCR2 signalling in human monocytes by Day, Priscilla, Burrows, Lisa, Richards, David, Fountain, Samuel J.

“…Background and Purpose CCL2 is an inflammatory chemokine that stimulates the recruitment of monocytes into tissue via activation of the GPCR CCR2. Experimental…”
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Constitutive P2Y2 receptor activity regulates basal lipolysis in human adipocytes by Ali, Seema B., Turner, Jeremy J. O., Fountain, Samuel J.

“…ABSTRACT White adipocytes are key regulators of metabolic homeostasis, which release stored energy as free fatty acids via lipolysis. Adipocytes possess both…”
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P2Y 2 and P2Y 6 receptor activation elicits intracellular calcium responses in human adipose-derived mesenchymal stromal cells by Ali, Seema, Turner, Jeremy, Fountain, Samuel J

“…Adipose tissue contains self-renewing multipotent cells termed mesenchymal stromal cells. In situ, these cells serve to expand adipose tissue by adipogenesis,…”
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Neuropeptide Y: Direct vasoconstrictor and facilitatory effects on P2X1 receptor-dependent vasoconstriction in human small abdominal arteries by del Carmen Gonzalez-Montelongo, Maria, Meades, Jessica Lauren, Fortuny-Gomez, Anna, Fountain, Samuel J.

“…Neuropeptide Y (NPY) is co-released with norepinephrine and ATP by sympathetic nerves innervating arteries. Circulating NPY is elevated during exercise and…”
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Evidence for Extracellular ATP as a Stress Signal in a Single-Celled Organism by Sivaramakrishnan, Venketesh, Fountain, Samuel J

“…ATP is omnipresent in biology and acts as an extracellular signaling molecule in mammals. Information regarding the signaling function of extracellular ATP in…”
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Primitive ATP-activated P2X receptors: discovery, function and pharmacology by Fountain, Samuel J

“…Adenosine 5-triphosphate (ATP) is omnipresent in biology. It is therefore no surprise that organisms have evolved multifaceted roles for ATP, exploiting its…”
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Transcriptional and Post-Translational Regulation of Junctional Adhesion Molecule-B (JAM-B) in Leukocytes under Inflammatory Stimuli by Day-Walsh, Priscilla E., Keeble, Bryony, Pirabagar, Gothai, Fountain, Samuel J., Kroon, Paul A.

“…Junctional adhesion molecules (JAMs; comprising JAM-A, -B and -C) act as receptors for viruses, mediate cell permeability, facilitate leukocyte migration…”
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Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3‐kinase inhibition by Nadzirin, Izzuddin Bin, Fortuny‐Gomez, Anna, Ngum, Neville, Richards, David, Ali, Seema, Searcey, Mark, Fountain, Samuel J.

“…Background and Purpose P2X4 is a ligand‐gated cation channel activated by extracellular ATP involved in neuropathic pain, inflammation and arterial tone…”
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Influence of ER leak on resting cytoplasmic Ca2+ and receptor-mediated Ca2+ signalling in human macrophage by Layhadi, Janice A., Fountain, Samuel J.

“…Mechanisms controlling endoplasmic reticulum (ER) Ca2+ homeostasis are important regulators of resting cytoplasmic Ca2+ concentration ([Ca2+]cyto) and…”
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Constitutive lysosome exocytosis releases ATP and engages P2Y receptors in human monocytes by Sivaramakrishnan, Venketesh, Bidula, Stefan, Campwala, Hinnah, Katikaneni, Divya, Fountain, Samuel J

“…Elucidating mechanisms by which Ca(2+) signals are generated by monocytes is important for understanding monocyte function in health and disease. We have…”
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A Mechanism of Intracellular P2X Receptor Activation by Sivaramakrishnan, Venketesh, Fountain, Samuel J.

“…P2X receptors (P2XRs) are ATP-activated calcium-permeable ligand-gated ion channels traditionally viewed as sensors of extracellular ATP during diverse…”
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