Search Results - "Foulds, Kathryn"

Early antibody therapy can induce long-lasting immunity to SHIV by Nishimura, Yoshiaki, Gautam, Rajeev, Chun, Tae-Wook, Sadjadpour, Reza, Foulds, Kathryn E., Shingai, Masashi, Klein, Florian, Gazumyan, Anna, Golijanin, Jovana, Donaldson, Mitzi, Donau, Olivia K., Plishka, Ronald J., Buckler-White, Alicia, Seaman, Michael S., Lifson, Jeffrey D., Koup, Richard A., Fauci, Anthony S., Nussenzweig, Michel C., Martin, Malcolm A.

“…Early administration of broadly neutralizing antibodies in a macaque SHIV infection model is associated with very low levels of persistent viraemia, which…”
Get full text

Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge by Stanley, Daphne A, Honko, Anna N, Asiedu, Clement, Trefry, John C, Lau-Kilby, Annie W, Johnson, Joshua C, Hensley, Lisa, Ammendola, Virginia, Abbate, Adele, Grazioli, Fabiana, Foulds, Kathryn E, Cheng, Cheng, Wang, Lingshu, Donaldson, Mitzi M, Colloca, Stefano, Folgori, Antonella, Roederer, Mario, Nabel, Gary J, Mascola, John, Nicosia, Alfredo, Cortese, Riccardo, Koup, Richard A, Sullivan, Nancy J

“…A chimpanzee adenovirus-based vaccination approach elicits acute and long-term protection against ebolavirus challenge in nonhuman primates. Ebolavirus disease…”
Get full text

Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1–4 by Stewart-Jones, Guillaume B. E., Chuang, Gwo-Yu, Xu, Kai, Zhou, Tongqing, Acharya, Priyamvada, Tsybovsky, Yaroslav, Ou, Li, Zhang, Baoshan, Fernandez-Rodriguez, Blanca, Gilardi, Valentina, Silacci-Fregni, Chiara, Beltramello, Martina, Baxa, Ulrich, Druz, Aliaksandr, Kong, Wing-Pui, Thomas, Paul V., Yang, Yongping, Foulds, Kathryn E., Todd, John-Paul, Wei, Hui, Salazar, Andres M., Scorpio, Diana G., Carragher, Bridget, Potter, Clinton S., Corti, Davide, Mascola, John R., Lanzavecchia, Antonio, Kwong, Peter D.

“…Parainfluenza virus types 1–4 (PIV1–4) are highly infectious human pathogens, of which PIV3 is most commonly responsible for severe respiratory illness in…”
Get full text

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1 by Xu, Kai, Acharya, Priyamvada, Kong, Rui, Cheng, Cheng, Chuang, Gwo-Yu, Liu, Kevin, Louder, Mark K., O’Dell, Sijy, Rawi, Reda, Sastry, Mallika, Shen, Chen-Hsiang, Zhang, Baoshan, Zhou, Tongqing, Asokan, Mangaiarkarasi, Bailer, Robert T., Chambers, Michael, Chen, Xuejun, Choi, Chang W., Dandey, Venkata P., Doria-Rose, Nicole A., Druz, Aliaksandr, Eng, Edward T., Farney, S. Katie, Foulds, Kathryn E., Geng, Hui, Georgiev, Ivelin S., Gorman, Jason, Hill, Kurt R., Jafari, Alexander J., Kwon, Young D., Lai, Yen-Ting, Lemmin, Thomas, McKee, Krisha, Ohr, Tiffany Y., Ou, Li, Peng, Dongjun, Rowshan, Ariana P., Sheng, Zizhang, Todd, John-Paul, Tsybovsky, Yaroslav, Viox, Elise G., Wang, Yiran, Wei, Hui, Yang, Yongping, Zhou, Amy F., Chen, Rui, Yang, Lu, Scorpio, Diana G., McDermott, Adrian B., Shapiro, Lawrence, Carragher, Bridget, Potter, Clinton S., Mascola, John R., Kwong, Peter D.

“…A central goal of HIV-1 vaccine research is the elicitation of antibodies capable of neutralizing diverse primary isolates of HIV-1. Here we show that focusing…”
Get full text

Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes by O'Brien, Sean P, Swanstrom, Adrienne E, Pegu, Amarendra, Ko, Sung-Youl, Immonen, Taina T, Del Prete, Gregory Q, Fennessey, Christine M, Gorman, Jason, Foulds, Kathryn E, Schmidt, Stephen D, Doria-Rose, Nicole, Williamson, Carolyn, Hatziioannou, Theodora, Bieniasz, Paul D, Li, Hui, Shaw, George M, Mascola, John R, Koup, Richard A, Kwong, Peter D, Lifson, Jeffrey D, Roederer, Mario, Keele, Brandon F

“…Chimeric Simian-Human Immunodeficiency Viruses (SHIVs) are an important tool for evaluating anti-HIV Env interventions in nonhuman primate (NHP) models…”
Get full text

Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection by Saunders, Kevin O, Wang, Lingshu, Joyce, M Gordon, Yang, Zhi-Yong, Balazs, Alejandro B, Cheng, Cheng, Ko, Sung-Youl, Kong, Wing-Pui, Rudicell, Rebecca S, Georgiev, Ivelin S, Duan, Lijie, Foulds, Kathryn E, Donaldson, Mitzi, Xu, Ling, Schmidt, Stephen D, Todd, John-Paul, Baltimore, David, Roederer, Mario, Haase, Ashley T, Kwong, Peter D, Rao, Srinivas S, Mascola, John R, Nabel, Gary J

“…Broadly neutralizing antibodies (bnAbs) can prevent lentiviral infection in nonhuman primates and may slow the spread of human immunodeficiency virus type 1…”
Get full text

Monocytes Acquire the Ability to Prime Tissue-Resident T Cells via IL-10-Mediated TGF-β Release by Thompson, Elizabeth A., Darrah, Patricia A., Foulds, Kathryn E., Hoffer, Elena, Caffrey-Carr, Alayna, Norenstedt, Sophie, Perbeck, Leif, Seder, Robert A., Kedl, Ross M., Loré, Karin

“…Using non-human primates (NHPs), mice, and human primary cells, we found a role for interleukin-10 (IL-10) in the upregulation of the tissue-resident memory…”
Get full text

Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in rhesus macaques coincides with anamnestic antibody response in the lung by Gagne, Matthew, Corbett, Kizzmekia S., Flynn, Barbara J., Foulds, Kathryn E., Wagner, Danielle A., Andrew, Shayne F., Todd, John-Paul M., Honeycutt, Christopher Cole, McCormick, Lauren, Nurmukhambetova, Saule T., Davis-Gardner, Meredith E., Pessaint, Laurent, Bock, Kevin W., Nagata, Bianca M., Minai, Mahnaz, Werner, Anne P., Moliva, Juan I., Tucker, Courtney, Lorang, Cynthia G., Zhao, Bingchun, McCarthy, Elizabeth, Cook, Anthony, Dodson, Alan, Teng, I-Ting, Mudvari, Prakriti, Roberts-Torres, Jesmine, Laboune, Farida, Wang, Lingshu, Goode, Adrienne, Kar, Swagata, Boyoglu-Barnum, Seyhan, Yang, Eun Sung, Shi, Wei, Ploquin, Aurélie, Doria-Rose, Nicole, Carfi, Andrea, Mascola, John R., Boritz, Eli A., Edwards, Darin K., Andersen, Hanne, Lewis, Mark G., Suthar, Mehul S., Graham, Barney S., Roederer, Mario, Moore, Ian N., Nason, Martha C., Sullivan, Nancy J., Douek, Daniel C., Seder, Robert A.

“…mRNA-1273 vaccine efficacy against SARS-CoV-2 Delta wanes over time; however, there are limited data on the impact of durability of immune responses on…”
Get full text

Interaction dynamics between innate and adaptive immune cells responding to SARS-CoV-2 vaccination in non-human primates by Schramm, Chaim A., Moon, Damee, Peyton, Lowrey, Lima, Noemia S., Wake, Christian, Boswell, Kristin L., Henry, Amy R., Laboune, Farida, Ambrozak, David, Darko, Samuel W., Teng, I-Ting, Foulds, Kathryn E., Carfi, Andrea, Edwards, Darin K., Kwong, Peter D., Koup, Richard A., Seder, Robert A., Douek, Daniel C.

“…As SARS-CoV-2 variants continue evolving, testing updated vaccines in non-human primates remains important for guiding human clinical practice. To date, such…”
Get full text

Imprinting of serum neutralizing antibodies by Wuhan-1 mRNA vaccines by Liang, Chieh-Yu, Raju, Saravanan, Liu, Zhuoming, Li, Yuhao, Asthagiri Arunkumar, Guha, Case, James Brett, Scheaffer, Suzanne M., Zost, Seth J., Acreman, Cory M., Gagne, Matthew, Andrew, Shayne F., Carvalho dos Anjos, Deborah Carolina, Foulds, Kathryn E., McLellan, Jason S., Crowe, James E., Douek, Daniel C., Whelan, Sean P. J., Elbashir, Sayda M., Edwards, Darin K., Diamond, Michael S.

“…Immune imprinting is a phenomenon in which prior antigenic experiences influence responses to subsequent infection or vaccination 1 , 2 . The effects of immune…”
Get full text

Vaccine nanodiscs plus polyICLC elicit robust CD8+ T cell responses in mice and non-human primates by Najafabadi, Alireza Hassani, Abadi, Zeynab Izadi Najaf, Aikins, Marisa E., Foulds, Kathryn E., Donaldson, Mitzi M., Yuan, Wenmin, Okeke, Emeka B., Nam, Jutaek, Xu, Yao, Weerappuli, Priyan, Hetrick, Taryn, Adams, David, Lester, Patrick A., Salazar, Andres M., Barouch, Dan H., Schwendeman, Anna, Seder, Robert A., Moon, James J.

“…Conventional cancer vaccines based on soluble vaccines and traditional adjuvants have produced suboptimal therapeutic efficacy in clinical trials. Thus, there…”
Get full text

Immune Activation Profiles Elicited by Distinct, Repeated TLR Agonist Infusions in Rhesus Macaques by King, Hannah A D, Pokkali, Supriya, Kim, Dohoon, Brammer, Daniel, Song, Kaimei, McCarthy, Elizabeth, Lehman, Chelsea, Todd, John-Paul, Foulds, Kathryn E, Darrah, Patricia A, Seder, Robert A, Bolton, Diane L, Roederer, Mario

“…TLR agonists are a promising class of immune system stimulants investigated for immunomodulatory applications in cancer immunotherapy and viral diseases. In…”
Get full text

Variant-proof high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airways by Gagne, Matthew, Flynn, Barbara J., Honeycutt, Christopher Cole, Flebbe, Dillon R., Andrew, Shayne F., Provost, Samantha J., McCormick, Lauren, Van Ry, Alex, McCarthy, Elizabeth, Todd, John-Paul M., Bao, Saran, Teng, I-Ting, Marciano, Shir, Rudich, Yinon, Li, Chunlin, Jain, Shilpi, Wali, Bushra, Pessaint, Laurent, Dodson, Alan, Cook, Anthony, Lewis, Mark G., Andersen, Hanne, Zahradník, Jiří, Suthar, Mehul S., Nason, Martha C., Foulds, Kathryn E., Kwong, Peter D., Roederer, Mario, Schreiber, Gideon, Seder, Robert A., Douek, Daniel C.

“…SARS-CoV-2 has the capacity to evolve mutations that escape vaccine- and infection-acquired immunity and antiviral drugs. A variant-agnostic therapeutic agent…”
Get full text

HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of SIVmac251 acquisition by Vaccari, Monica, Fourati, Slim, Gordon, Shari N., Brown, Dallas R., Bissa, Massimilano, Schifanella, Luca, Silva de Castro, Isabela, Doster, Melvin N., Galli, Veronica, Omsland, Maria, Fujikawa, Dai, Gorini, Giacomo, Liyanage, Namal P. M., Trinh, Hung V., McKinnon, Katherine M., Foulds, Kathryn E., Keele, Brandon F., Roederer, Mario, Koup, Richard A., Shen, Xiaoying, Tomaras, Georgia D., Wong, Marcus P., Munoz, Karissa J., Gach, Johannes S., Forthal, Donald N., Montefiori, David C., Venzon, David J., Felber, Barbara K., Rosati, Margherita, Pavlakis, George N., Rao, Mangala, Sekaly, Rafick-Pierre, Franchini, Genoveffa

“…Qualitative differences in the innate and adaptive responses elicited by different HIV vaccine candidates have not been thoroughly investigated. We tested the…”
Get full text

OMIP‐052: An 18‐Color Panel for Measuring Th1, Th2, Th17, and Tfh Responses in Rhesus Macaques by Donaldson, Mitzi M., Kao, Shing‐Fen, Foulds, Kathryn E.

Get full text

Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans by Ratnasiri, Kalani, Zheng, Hong, Toh, Jiaying, Yao, Zhiyuan, Duran, Veronica, Donato, Michele, Roederer, Mario, Kamath, Megha, Todd, John-Paul M., Gagne, Matthew, Foulds, Kathryn E., Francica, Joseph R., Corbett, Kizzmekia S., Douek, Daniel C., Seder, Robert A., Einav, Shirit, Blish, Catherine A., Khatri, Purvesh

“…Viral pandemics and epidemics pose a significant global threat. While macaque models of viral disease are routinely used, it remains unclear how conserved…”
Get full text

Protective antibodies elicited by SARS-CoV-2 spike protein vaccination are boosted in the lung after challenge in nonhuman primates by Francica, Joseph R, Flynn, Barbara J, Foulds, Kathryn E, Noe, Amy T, Werner, Anne P, Moore, Ian N, Gagne, Matthew, Johnston, Timothy S, Tucker, Courtney, Davis, Rachel L, Flach, Britta, O'Connell, Sarah, Andrew, Shayne F, Lamb, Evan, Flebbe, Dillon R, Nurmukhambetova, Saule T, Donaldson, Mitzi M, Todd, John-Paul M, Zhu, Alex Lee, Atyeo, Caroline, Fischinger, Stephanie, Gorman, Matthew J, Shin, Sally, Edara, Venkata Viswanadh, Floyd, Katharine, Lai, Lilin, Boyoglu-Barnum, Seyhan, Van De Wetering, Renee, Tylor, Alida, McCarthy, Elizabeth, Lecouturier, Valerie, Ruiz, Sophie, Berry, Catherine, Tibbitts, Timothy, Andersen, Hanne, Cook, Anthony, Dodson, Alan, Pessaint, Laurent, Van Ry, Alex, Koutsoukos, Marguerite, Gutzeit, Cindy, Teng, I-Ting, Zhou, Tongqing, Li, Dapeng, Haynes, Barton F, Kwong, Peter D, McDermott, Adrian, Lewis, Mark G, Fu, Tong Ming, Chicz, Roman, van der Most, Robbert, Corbett, Kizzmekia S, Suthar, Mehul S, Alter, Galit, Roederer, Mario, Sullivan, Nancy J, Douek, Daniel C, Graham, Barney S, Casimiro, Danilo, Seder, Robert A

“…Adjuvanted soluble protein vaccines have been used extensively in humans for protection against various viral infections based on their robust induction of…”
Get more information

Interprotomer disulfide-stabilized variants of the human metapneumovirus fusion glycoprotein induce high titer-neutralizing responses by Stewart-Jones, Guillaume B. E., Gorman, Jason, Ou, Li, Zhang, Baoshan, Joyce, M. Gordon, Yang, Lijuan, Cheng, Cheng, Chuang, Gwo-Yu, Foulds, Kathryn E., Kong, Wing-Pui, Olia, Adam S., Sastry, Mallika, Shen, Chen-Hsiang, Todd, John-Paul, Tsybovsky, Yaroslav, Verardi, Raffaello, Yang, Yongping, Collins, Peter L., Corti, Davide, Lanzavecchia, Antonio, Scorpio, Diana G., Mascola, John R., Buchholz, Ursula J., Kwong, Peter D.

“…Human metapneumovirus (HMPV) is a major cause of respiratory disease worldwide, particularly among children and the elderly. Although there is no licensed HMPV…”
Get full text

Rhesus macaque Bcl-6/Bcl-xL B cell immortalization: Discovery of HIV-1 neutralizing antibodies from lymph node by Samsel, Jakob, Boswell, Kristin L., Watkins, Timothy, Ambrozak, David R., Mason, Rosemarie, Yamamoto, Takuya, Ko, Sungyoul, Yang, Yongping, Zhou, Tongqing, Doria-Rose, Nicole A., Foulds, Kathryn E., Roederer, Mario, Mascola, John R., Kwong, Peter D., Gama, Lucio, Koup, Richard A.

“…Many HIV-1 vaccines are designed to elicit neutralizing antibodies, and pre-clinical testing is often carried out in rhesus macaques (RMs). We have therefore…”
Get full text

A single-shot ChAd3-MARV vaccine confers rapid and durable protection against Marburg virus in nonhuman primates by Hunegnaw, Ruth, Honko, Anna N, Wang, Lingshu, Carr, Derick, Murray, Tamar, Shi, Wei, Nguyen, Lam, Storm, Nadia, Dulan, Caitlyn N M, Foulds, Kathryn E, Agans, Krystle N, Cross, Robert W, Geisbert, Joan B, Cheng, Cheng, Ploquin, Aurélie, Stanley, Daphne A, Geisbert, Thomas W, Nabel, Gary J, Sullivan, Nancy J

“…Marburg virus (MARV) causes a severe hemorrhagic fever disease in primates with mortality rates in humans of up to 90%. MARV has been identified as a category…”
Get more information