Search Results - "Foucault‐Bertaud, Alexandrine"

Therapeutic targeting of soluble CD146/MCAM with the M2J‐1 monoclonal antibody prevents metastasis development and procoagulant activity in CD146‐positive invasive tumors by Stalin, Jimmy, Traboulsi, Wael, Vivancos‐Stalin, Lucie, Nollet, Marie, Joshkon, Ahmad, Bachelier, Richard, Guillet, Benjamin, Lacroix, Romaric, Foucault‐Bertaud, Alexandrine, Leroyer, Aurélie S., Dignat‐George, Françoise, Bardin, Nathalie, Blot‐Chabaud, Marcel

“…Initially discovered in human melanoma, CD146/MCAM is expressed on many tumors and is correlated with cancer progression and metastasis. However, targeting…”
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Involvement of Multiple Variants of Soluble CD146 in Systemic Sclerosis: Identification of a Novel Profibrotic Factor by Nollet, Marie, Bachelier, Richard, Joshkon, Ahmad, Traboulsi, Waël, Mahieux, Amandine, Moyon, Anais, Muller, Alexandre, Somasundaram, Indumathi, Simoncini, Stéphanie, Peiretti, Franck, Leroyer, Aurélie S., Guillet, Benjamin, Granel, Brigitte, Dignat‐George, Françoise, Bardin, Nathalie, Foucault‐Bertaud, Alexandrine, Blot‐Chabaud, Marcel

“…Objective Systemic sclerosis (SSc) is an autoimmune disorder characterized by excessive fibrosis, immune dysfunction, and vascular damage, in which the…”
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Soluble CD146 as a Potential Target for Preventing Triple Negative Breast Cancer MDA-MB-231 Cell Growth and Dissemination by Sharma, Akshita, Joshkon, Ahmad, Ladjimi, Aymen, Traboulsi, Waël, Bachelier, Richard, Robert, Stéphane, Foucault-Bertaud, Alexandrine, Leroyer, Aurélie S, Bardin, Nathalie, Somasundaram, Indumathi, Blot-Chabaud, Marcel

“…Triple Negative Breast Cancers (TNBC) are the most aggressive breast cancers and lead to poor prognoses. This is due to a high resistance to therapies, mainly…”
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Role of CD146 (MCAM) in Physiological and Pathological Angiogenesis-Contribution of New Antibodies for Therapy by Joshkon, Ahmad, Heim, Xavier, Dubrou, Cléa, Bachelier, Richard, Traboulsi, Wael, Stalin, Jimmy, Fayyad-Kazan, Hussein, Badran, Bassam, Foucault-Bertaud, Alexandrine, Leroyer, Aurelie S, Bardin, Nathalie, Blot-Chabaud, Marcel

“…The fundamental role of cell adhesion molecules in mediating various biological processes as angiogenesis has been well-documented. CD146, an adhesion molecule…”
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Transplanted Late Outgrowth Endothelial Progenitor Cells as Cell Therapy Product for Stroke by Moubarik, Chahrazad, Guillet, Benjamin, Youssef, Bennis, Codaccioni, Jean-Laurent, Piercecchi, Marie-Dominique, Sabatier, Florence, Lionel, Pellegrini, Dou, Laetitia, Foucault-Bertaud, Alexandrine, Velly, Lionel, Dignat-George, Françoise, Pisano, Pascale

“…Endothelial progenitor cells (EPCs) seem to be a promising option to treat patients with ischemic diseases. Here, we investigated the effects of late outgrowth…”
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Identification of CD146 as a novel molecular actor involved in systemic sclerosis by Kaspi, Elise, PharmD, PhD, Heim, Xavier, Granel, Brigitte, MD, PhD, Guillet, Benjamin, PharmD, PhD, Stalin, Jimmy, PhD, Nollet, Marie, Bertaud-Foucault, Alexandrine, PhD, Robaglia-Schlupp, Andrée, MD, Roll, Patrice, MD, PhD, Cau, Pierre, MD, PhD, Leroyer, Aurélie, PhD, Bachelier, Richard, PhD, Benyamine, Audrey, MD, PhD, Dignat-George, Françoise, PharmD, PhD, Blot-Chabaud, Marcel, PhD, Bardin, Nathalie, PharmD, PhD

“…Interestingly, injection of sCD146 in bleomycin-treated CD146KO mice showed a significant reduction in dermal and epidermal thickness as compared with…”
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Soluble CD146, a biomarker and a target for preventing resistance to anti-angiogenic therapy in glioblastoma by Joshkon, Ahmad, Tabouret, Emeline, Traboulsi, Wael, Bachelier, Richard, Simoncini, Stéphanie, Roffino, Sandrine, Jiguet-Jiglaire, Carine, Badran, Bassam, Guillet, Benjamin, Foucault-Bertaud, Alexandrine, Leroyer, Aurelie S, Dignat-George, Françoise, Chinot, Olivier, Fayyad-Kazan, Hussein, Bardin, Nathalie, Blot-Chabaud, Marcel

“…Glioblastoma multiforme (GBM) is a primary brain tumor with poor prognosis. The U.S. food and drug administration approved the use of the anti-VEGF antibody…”
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Soluble CD146 displays angiogenic properties and promotes neovascularization in experimental hind-limb ischemia by Harhouri, Karim, Kebir, Abdeldjalil, Guillet, Benjamin, Foucault-Bertaud, Alexandrine, Voytenko, Serge, Piercecchi-Marti, Marie-Dominique, Berenguer, Caroline, Lamy, Edouard, Vely, Frédéric, Pisano, Pascale, Ouafik, L'Houcine, Sabatier, Florence, Sampol, José, Bardin, Nathalie, Dignat-George, Françoise, Blot-Chabaud, Marcel

“…CD146, an endothelial molecule involved in permeability and monocyte transmigration, has recently been reported to promote vessel growth. As CD146 is also…”
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CD146/sCD146 in the Pathogenesis and Monitoring of Angiogenic and Inflammatory Diseases by Heim, Xavier, Joshkon, Ahmad, Bermudez, Julien, Bachelier, Richard, Dubrou, Cléa, Boucraut, José, Foucault-Bertaud, Alexandrine, Leroyer, Aurélie S, Dignat-George, Francoise, Blot-Chabaud, Marcel, Bardin, Nathalie

“…CD146 is a cell adhesion molecule expressed on endothelial cells, as well as on other cells such as mesenchymal stem cells and Th17 lymphocytes. This protein…”
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CD146 Short Isoform Increases the Proangiogenic Potential of Endothelial Progenitor Cells In Vitro and In Vivo by Kebir, Abdeldjalil, Harhouri, Karim, Guillet, Benjamin, Liu, Jia Wei, Foucault-Bertaud, Alexandrine, Lamy, Edouard, Kaspi, Elise, Elganfoud, Nadia, Vely, Frédéric, Sabatier, Florence, Sampol, José, Pisano, Pascale, Kruithof, Egbert K.O, Bardin, Nathalie, Dignat-George, Françoise, Blot-Chabaud, Marcel

“…RATIONALE:CD146, a transmembrane immunoglobulin mainly expressed at the intercellular junction of endothelial cells, is involved in cell-cell cohesion,…”
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Fucoidan a sulfated polysaccharide from brown algae is a potent modulator of connective tissue proteolysis by Senni, Karim, Gueniche, Farida, Foucault-Bertaud, Alexandrine, Igondjo-Tchen, Sylvie, Fioretti, Florence, Colliec-Jouault, Sylvia, Durand, Patrick, Guezennec, Jean, Godeau, Gaston, Letourneur, Didier

“…Fucoidans are sulfated fucosylated polymers from brown algae cell wall that exhibit some heparin/heparan sulfate properties. We previously demonstrated that…”
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Changes in the physical structure and chain dynamics of elastin network in homocysteine-cultured arteries by Samouillan, Valérie, Lamy, Edouard, Dandurand, Jany, Foucault-Bertaud, Alexandrine, Chareyre, Corinne, Lacabanne, Colette, Charpiot, Philippe

“…The thermal and dielectric properties of the elastin network were investigated in arteries cultured with physiological and pathological concentrations of…”
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CD146 at the Interface between Oxidative Stress and the Wnt Signaling Pathway in Systemic Sclerosis by Heim, Xavier, Bermudez, Julien, Joshkon, Ahmad, Kaspi, Elise, Bachelier, Richard, Nollet, Marie, Vélier, Mélanie, Dou, Laetitia, Brodovitch, Alexandre, Foucault-Bertaud, Alexandrine, Leroyer, Aurelie S., Benyamine, Audrey, Daumas, Aurélie, Granel, Brigitte, Sabatier, Florence, Dignat-George, Françoise, Blot-Chabaud, Marcel, Bardin, Nathalie

“…CD146 involvement was recently described in skin fibrosis of systemic sclerosis through its regulation of the Wnt pathway. Because the interaction between Wnt…”
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Therapeutic targeting of soluble CD146/MCAM with the M2J‐1 monoclonal antibody prevents metastasis development and procoagulant activity in CD146‐positive invasive tumors by Leroyer, Aurelie, Stalin, Jimmy, Traboulsi, Wael, Vivancos‐stalin, Lucie, Nollet, Marie, Joshkon, Ahmad, Bachelier, Richard, Guillet, Benjamin, Lacroix, Romaric, Foucault‐bertaud, Alexandrine, Dignat‐george, Françoise, Bardin, Nathalie, Blot‐chabaud, Marcel

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Endothelial-Specific Deletion of CD146 Protects Against Experimental Glomerulonephritis in Mice by Abed, Ahmed, Leroyer, Aurélie S., Kavvadas, Panagiotis, Authier, Florence, Bachelier, Richard, Foucault-Bertaud, Alexandrine, Bardin, Nathalie, Cohen, Clemens D., Lindenmeyer, Maja T., Genest, Magali, Joshkon, Ahmad, Jourde-Chiche, Noémie, Burtey, Stéphane, Blot-Chabaud, Marcel, Dignat-George, Françoise, Chadjichristos, Christos E.

“…CD146 is an endothelial junctional adhesion molecule, which expression is increased in human glomerular diseases. However, the pathological significance of…”
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Targeting soluble CD146 with a neutralizing antibody inhibits vascularization, growth and survival of CD146-positive tumors by Stalin, J, Nollet, M, Garigue, P, Fernandez, S, Vivancos, L, Essaadi, A, Muller, A, Bachelier, R, Foucault-Bertaud, A, Fugazza, L, Leroyer, A S, Bardin, N, Guillet, B, Dignat-George, F, Blot-Chabaud, M

“…CD146 (MUC-18, MCAM) expression on cancer cells correlates with cancer progression and a bad prognosis in several tumors, including melanoma and pancreatic…”
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Soluble CD146 boosts therapeutic effect of endothelial progenitors through proteolytic processing of short CD146 isoform by Stalin, Jimmy, Harhouri, Karim, Hubert, Lucas, Garrigue, Philippe, Nollet, Marie, Essaadi, Amel, Muller, Alexandre, Foucault-Bertaud, Alexandrine, Bachelier, Richard, Sabatier, Florence, Pisano, Pascale, Peiretti, Franck, Leroyer, Aurélie S, Guillet, Benjamin, Bardin, Nathalie, Dignat-George, Françoise, Blot-Chabaud, Marcel

“…Endothelial colony-forming cells (ECFC) constitute an endothelial progenitor fraction with a promising interest for the treatment of ischaemic cardiovascular…”
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Negative impact of disuse and unloading on tendon enthesis structure and function by Roffino, S., Camy, C., Foucault-Bertaud, A., Lamy, E., Pithioux, M., Chopard, A.

“…Exposure to chronic skeletal muscle disuse and unloading that astronauts experience results in muscle deconditioning and bone remodeling. Tendons involved in…”
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CD146 deficiency promotes plaque formation in a mouse model of atherosclerosis by enhancing RANTES secretion and leukocyte recruitment by Blin, Muriel, Bachelier, Richard, Fallague, Karim, Moussouni, Karima, Aurrand-Lions, Michel, Fernandez, Samantha, Guillet, Benjamin, Robert, Stéphane, Foucault-Bertaud, Alexandrine, Bardin, Nathalie, Blot-Chabaud, Marcel, Dignat-George, Françoise, Leroyer, Aurelie

“…Aims: The progression of atherosclerosis is based on the continued recruitment of leukocytes in the vessel wall. The previously described role of CD146 in…”
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CD146 deficiency promotes plaque formation in a mouse model of atherosclerosis by enhancing RANTES secretion and leukocyte recruitment by Blin, Muriel G., Bachelier, Richard, Fallague, Karim, Moussouni, Karima, Aurrand-Lions, Michel, Fernandez, Samantha, Guillet, Benjamin, Robert, Stéphane, Foucault-Bertaud, Alexandrine, Bardin, Nathalie, Blot-Chabaud, Marcel, Dignat-George, Françoise, Leroyer, Aurélie S.

“…The progression of atherosclerosis is based on the continued recruitment of leukocytes in the vessel wall. The previously described role of CD146 in leukocyte…”
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