Long-term outcomes of malignant phyllodes tumors patients: an institutional experience

Malignant phyllodes tumors are an extremely rare breast tumor. Prognostic features and overall survival data have not been consistent across studies. Retrospectively, we examined the clinicopathologic features of 27 breast cancer patients treated for malignant phyllodes tumors from 1995 to 2004 and...

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Bibliographic Details
Published in:	The American journal of surgery Vol. 192; no. 4; pp. 492 - 495
Main Authors:	Fou, Adora, Schnabel, Freya R., Hamele-Bena, Diane, Wei, Xiao-Jun, Cheng, Bin, El Tamer, Mahmoud, Klein, Laura, Joseph, Kathie Ann
Format:	Journal Article Conference Proceeding
Language:	English
Published:	New York, NY Elsevier Inc 01-10-2006 Elsevier Elsevier Limited
Subjects:	Adolescent Adult Age Biological and medical sciences Breast cancer Breast Neoplasms - mortality Breast Neoplasms - pathology Breast Neoplasms - therapy Cystosarcoma phyllodes Cysts Ethnicity Female Follow-Up Studies General aspects Gynecology. Andrology. Obstetrics Histology Humans Hyperplasia Malignant phyllodes tumors Mammary gland diseases Mastectomy Medical sciences Metastasis Middle Aged Mitotic Index Mortality Neoplasm Invasiveness Phyllodes Tumor - mortality Phyllodes Tumor - secondary Phyllodes Tumor - therapy Phyllodes tumors Retrospective Studies Surgery Survival Rate Treatment Outcome Tumors Malignant phyllodes tumors Cystosarcoma phyllodes Breast cancer Phyllodes tumors Human Prognosis Patient Institution Malignant tumor Long term Medicine Mammary gland diseases Treatment Surgery Evolution Mammary gland Phyllode tumor
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Summary:	Malignant phyllodes tumors are an extremely rare breast tumor. Prognostic features and overall survival data have not been consistent across studies. Retrospectively, we examined the clinicopathologic features of 27 breast cancer patients treated for malignant phyllodes tumors from 1995 to 2004 and analyzed their recurrence and survival outcomes using contingency tables, a logistic regression model, or a proportional hazard model. The mortality rate was 12% (n = 3) of the cohort and 75% of the group with distant metastases. The median follow-up period was 51 months (range, 12–192 mo). A mitotic index greater than 10 per high-powered field, the presence of stromal overgrowth, mastectomy at initial surgery, and larger tumor size were associated with an increased incidence of distant metastases. Larger tumor size also was associated with an increased incidence of death. Most patients with malignant phyllodes tumors will enjoy significant long-term survival if treated appropriately with local excision with clear margins.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-9610 1879-1883
DOI:	10.1016/j.amjsurg.2006.06.017