Search Results - "Foster, John G"

Inhibition of PI3K signaling spurs new therapeutic opportunities in inflammatory/autoimmune diseases and hematological malignancies by Foster, John G, Blunt, Matthew D, Carter, Edward, Ward, Stephen G

“…The phosphoinositide 3-kinase/mammalian target of rapamycin/protein kinase B (PI3K/mTOR/Akt) signaling pathway is central to a plethora of cellular mechanisms…”
Get full text

Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins by Bridge, Katherine S., Shah, Kunal M., Li, Yigen, Foxler, Daniel E., Wong, Sybil C.K., Miller, Duncan C., Davidson, Kathryn M., Foster, John G., Rose, Ruth, Hodgkinson, Michael R., Ribeiro, Paulo S., Aboobaker, A. Aziz, Yashiro, Kenta, Wang, Xiaozhong, Graves, Paul R., Plevin, Michael J., Lagos, Dimitris, Sharp, Tyson V.

“…As core components of the microRNA-induced silencing complex (miRISC), Argonaute (AGO) proteins interact with TNRC6 proteins, recruiting other effectors of…”
Get full text

The hypoxic tumor microenvironment: driving the tumorigenesis of non-small-cell lung cancer by Foster, John G, Wong, Sybil C K, Sharp, Tyson V

“…Since the application of molecular biology in cancer biology, lung cancer research has classically focused on molecular drivers of disease. One such pathway,…”
Get more information

FOXA1 regulates alternative splicing in prostate cancer by Del Giudice, Marco, Foster, John G., Peirone, Serena, Rissone, Alberto, Caizzi, Livia, Gaudino, Federica, Parlato, Caterina, Anselmi, Francesca, Arkell, Rebecca, Guarrera, Simonetta, Oliviero, Salvatore, Basso, Giuseppe, Rajan, Prabhakar, Cereda, Matteo

“…Dysregulation of alternative splicing in prostate cancer is linked to transcriptional programs activated by AR, ERG, FOXA1, and MYC. Here, we show that FOXA1…”
Get full text

Mitochondrial superoxide generation enhances P2X7R-mediated loss of cell surface CD62L on naive human CD4+ T lymphocytes by Foster, John G, Carter, Edward, Kilty, Iain, MacKenzie, Amanda B, Ward, Stephen G

“…Migration of naive CD4(+) T lymphocytes into lymphoid tissue is essential for their activation and subsequent roles in adaptive immunity. The adhesion molecule…”
Get full text

A HIF–LIMD1 negative feedback mechanism mitigates the pro‐tumorigenic effects of hypoxia by Foxler, Daniel E, Bridge, Katherine S, Foster, John G, Grevitt, Paul, Curry, Sean, Shah, Kunal M, Davidson, Kathryn M, Nagano, Ai, Gadaleta, Emanuela, Rhys, Hefin I, Kennedy, Paul T, Hermida, Miguel A, Chang, Ting‐Yu, Shaw, Peter E, Reynolds, Louise E, McKay, Tristan R, Wang, Hsei‐Wei, Ribeiro, Paulo S, Plevin, Michael J, Lagos, Dimitris, Lemoine, Nicholas R, Rajan, Prabhakar, Graham, Trevor A, Chelala, Claude, Hodivala‐Dilke, Kairbaan M, Spendlove, Ian, Sharp, Tyson V

“…The adaptive cellular response to low oxygen tensions is mediated by the hypoxia‐inducible factors (HIFs), a family of heterodimeric transcription factors…”
Get full text

Evidence that the lipid phosphatase SHIP-1 regulates T lymphocyte morphology and motility by Harris, Stephanie J, Parry, Richard V, Foster, John G, Blunt, Matthew D, Wang, Amu, Marelli-Berg, Federica, Westwick, John, Ward, Stephen G

“…SHIP-1 negatively regulates the PI3K pathway in hematopoietic cells and has an emerging role in T lymphocyte biology. PI3K and SHIP can regulate cell migration…”
Get full text

PI3K isoforms as drug targets in inflammatory diseases: lessons from pharmacological and genetic strategies by Harris, Stephanie J, Foster, John G, Ward, Stephen G

“…Inflammation protects the body against infection and injury, but it is a process that can become dysregulated with deleterious consequences, including the…”
Get more information

Mitochondrial Superoxide Generation Enhances P2X7R-mediated Loss of Cell Surface CD62L on Naïve Human CD4+ T Lymphocytes1 by Foster, John G., Carter, Edward, Kilty, Iain, MacKenzie, Amanda B., Ward, Stephen G.

“…Migration of naïve CD4 + T lymphocytes into lymphoid tissue is essential for their activation and subsequent roles in adaptive immunity. The adhesion molecule…”
Get full text

A HIF – LIMD 1 negative feedback mechanism mitigates the pro‐tumorigenic effects of hypoxia by Foxler, Daniel E, Bridge, Katherine S, Foster, John G, Grevitt, Paul, Curry, Sean, Shah, Kunal M, Davidson, Kathryn M, Nagano, Ai, Gadaleta, Emanuela, Rhys, Hefin I, Kennedy, Paul T, Hermida, Miguel A, Chang, Ting‐Yu, Shaw, Peter E, Reynolds, Louise E, McKay, Tristan R, Wang, Hsei‐Wei, Ribeiro, Paulo S, Plevin, Michael J, Lagos, Dimitris, Lemoine, Nicholas R, Rajan, Prabhakar, Graham, Trevor A, Chelala, Claude, Hodivala‐Dilke, Kairbaan M, Spendlove, Ian, Sharp, Tyson V

“…The adaptive cellular response to low oxygen tensions is mediated by the hypoxia‐inducible factors (HIFs), a family of heterodimeric transcription factors…”
Get full text

The role of phosphatidylinositol 3-kinase in P2X7R gated signalling in T lymphocytes by Foster, John G

“…Background: The role of P2X7R in the immune response has been investigated and this receptor clearly has important roles in inflammation. However, the…”
Get full text

Variations in lower thermosphere dynamics at midlatitudes during intense geomagnetic storms by Goncharenko, Larisa P., Salah, Joseph E., Foster, John C., Huang, Chaosong

“…High‐resolution observations of the dynamics of the ionospheric E region (100–150 km) at midlatitudes have been made with the incoherent scatter radar at…”
Get full text

NOVA SCOTIA. Compulsory vaccination in Halifax by Foster, John G.

Get full text

GERMANY. Arrival at Halifax, of steamship Pisa, from Hamburg, with 3 cases of smallpox on board by Cridler, Thos. W., Foster, John G., Moore, J. B.

Get full text

How the War Transformed England by Sir John Foster Fraser F R G S

Get full text