Search Results - "Foster, J. R"

Liver Hypertrophy: A Review of Adaptive (Adverse and Non-adverse) Changes—Conclusions from the 3rd International ESTP Expert Workshop by Hall, A. P., Elcombe, C. R., Foster, J. R., Harada, T., Kaufmann, W., Knippel, A., Küttler, K., Malarkey, D. E., Maronpot, R. R., Nishikawa, A., Nolte, T., Schulte, A., Strauss, V., York, M. J.

“…Preclinical toxicity studies have demonstrated that exposure of laboratory animals to liver enzyme inducers during preclinical safety assessment results in a…”
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Population In Vitro-In Vivo Correlation Model Linking Gastrointestinal Transit Time, pH, and Pharmacokinetics: Itraconazole as a Model Drug by Abuhelwa, Ahmad Y., Mudge, Stuart, Hayes, David, Upton, Richard N., Foster, David J. R.

“…Purpose To establish an in vitro-in vivo correlation (IVIVC) model for Sporanox and SUBA-itraconazole formulations and to understand the impact of…”
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Quantitative parametric MRI of articular cartilage: a review of progress and open challenges by Binks, D A, Hodgson, R J, Ries, M E, Foster, R J, Smye, S W, McGonagle, D, Radjenovic, A

“…With increasing life expectancies and the desire to maintain active lifestyles well into old age, the impact of the debilitating disease osteoarthritis (OA)…”
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Pharmacokinetics of caspofungin acetate to guide optimal dosing in cats by Leshinsky, Jana, McLachlan, Andrew, Foster, David J R, Norris, Ross, Barrs, Vanessa R

“…Cats are the most common mammal to develop invasive fungal rhinosinusitis caused by cryptic species in Aspergillus section Fumigati that are resistant to…”
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A Quantitative Review and Meta-Models of the Variability and Factors Affecting Oral Drug Absorption—Part I: Gastrointestinal pH by Abuhelwa, Ahmad Y., Foster, David J. R., Upton, Richard N.

“…This study aimed to conduct a quantitative meta-analysis for the values of, and variability in, gastrointestinal (GI) pH in the different GI segments;…”
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Pharmacokinetics and cardiovascular effects following a single oral administration of a nonaqueous pimobendan solution in healthy dogs by Yata, M., McLachlan, A. J., Foster, D. J. R., Page, S. W., Beijerink, N. J.

“…Pimobendan is an inodilator used in the treatment of canine congestive heart failure (CHF). The aim of this study was to investigate the pharmacokinetics and…”
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Seasonal and annual changes in soil respiration in relation to soil temperature, water potential and trenching by Lavigne, M B, Foster, R J, Goodine, G

“…Soil respiration (rs), soil temperature (Ts) and volumetric soil water content were measured in a balsam fir (Abies balsamea (L.) Mill.) ecosystem from 1998 to…”
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A Quantitative Review and Meta-models of the Variability and Factors Affecting Oral Drug Absorption—Part II: Gastrointestinal Transit Time by Abuhelwa, Ahmad Y., Foster, David J. R., Upton, Richard N.

“…This study aimed to conduct a quantitative meta-analysis for the values of, and variability in, gastrointestinal (GI) transit times of non-disintegrating…”
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Population pharmacokinetic modeling of itraconazole and hydroxyitraconazole for oral SUBA-itraconazole and sporanox capsule formulations in healthy subjects in fed and fasted states by Abuhelwa, Ahmad Y, Foster, David J R, Mudge, Stuart, Hayes, David, Upton, Richard N

“…Itraconazole is an orally active antifungal agent that has complex and highly variable absorption kinetics that is highly affected by food. This study aimed to…”
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A history of blood glucose meters and their role in self-monitoring of diabetes mellitus by Clarke, S. F., Foster, J. R.

“…Self-monitoring blood glucose (SMBG) systems have the potential to play an important role in the management of diabetes and in the reduction of risk of serious…”
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(R)‐ and (S)‐methadone and buprenorphine concentration ratios in maternal and umbilical cord plasma following chronic maintenance dosing in pregnancy by Gordon, Andrea L., Lopatko, Olga V., Somogyi, Andrew A., Foster, David J. R., White, Jason M.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Both methadone and buprenorphine cross the placenta during pregnancy which can result in neonatal abstinence syndrome…”
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Imaging of nuclear magnetic resonance spin–lattice relaxation activation energy in cartilage by Foster, R. J., Damion, R. A., Ries, M. E., Smye, S. W., McGonagle, D. G., Binks, D. A., Radjenovic, A.

“…Samples of human and bovine cartilage have been examined using magnetic resonance imaging to determine the proton nuclear magnetic resonance spin–lattice…”
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The anisotropic hydraulic permeability of human lumbar anulus fibrosus. Influence of age, degeneration, direction, and water content by GU, W. Y, MAO, X. G, FOSTER, R. J, WEIDENBAUM, M, MOW, V. C, RAWLINS, B. A

“…Experimental investigation to determine the effect of intervertebral disc degeneration on the kinetic behavior of fluid in human anulus fibrosus. To measure…”
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Pharmacokinetic–Pharmacodynamic Modelling of the Analgesic and Antihyperalgesic Effects of Morphine after Intravenous Infusion in Human Volunteers by Ravn, Pernille, Foster, David J.R., Kreilgaard, Mads, Christrup, Lona, Werner, Mads U., Secher, Erik L., Skram, Ulrik, Upton, Richard

“…Using a modelling approach, this study aimed to (i) examine whether the pharmacodynamics of the analgesic and antihyperalgesic effects of morphine differ; (ii)…”
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Pharmacokinetic/Pharmacodynamic Relationships of Transdermal Buprenorphine and Fentanyl in Experimental Human Pain Models by Andresen, Trine, Upton, Richard N., Foster, David J.R., Christrup, Lona L., Arendt‐Nielsen, Lars, Drewes, Asbjørn M.

“…:  Pharmacokinetic/pharmacodynamic (PK/PD) modelling can be used to characterize the relationship between dose regimen of opioids, plasma concentration and…”
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A Pharmacokinetic and Pharmacodynamic Study of Oral Oxycodone in a Human Experimental Pain Model of Hyperalgesia by Olesen, Anne E., Upton, Richard, Foster, David J. R., Staahl, Camilla, Christrup, Lona L., Arendt-Nielsen, Lars, Drewes, Asbjørn M.

“…Background and Objective Oxycodone is not as well characterized, with respect to its pharmacokinetic/ pharmacodynamic properties, as other opioids. Moreover,…”
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Pharmacokinetic-Pharmacodynamic Modeling of Morphine and Oxycodone Concentrations and Analgesic Effect in a Multimodal Experimental Pain Model by Staahl, Camilla, Upton, Richard, Foster, David J. R., Christrup, Lona Louring, Kristensen, Kim, Hansen, Steen Honoré, Arendt-Nielsen, Lars, Drewes, Asbjørn Mohr

“…Analgesia from most opioids is mediated by μ receptors located mainly in the central nervous system. Previous studies have shown a different pharmacological…”
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CYP2C19-guided design of a proton pump inhibitor dose regimen to avoid the need for pharmacogenetic individualisation in H. pylori eradication by Ward, Michael B., Foster, David J. R.

“…Objective It has been demonstrated that genetic variation in CYP2C19 has a significant influence upon H. pylori eradication rates. We have determined a dosage…”
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Methadone N‐demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4 by Foster, David J. R., Somogyi, Andrew A., Bochner, Felix

“…Aims To investigate the kinetics of CYP‐mediated N‐demethylation of methadone in human liver microsomes, and examine the role of stereoselectivity and CYP…”
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Acute paraumbilical vein recanalization: an unusual complication of acute pancreatitis by Foster, R J, Cowell, G W

“…Acute pancreatitis is associated with a number of well-known complications and imaging findings. Spontaneous recanalization of the paraumbilical veins as a…”
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