Search Results - "Foster, Daniel J"

Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders by Foster, Daniel J., Conn, P. Jeffrey

“…G-protein-coupled receptors (GPCRs) play critical roles in regulating brain function. Recent advances have greatly expanded our understanding of these…”
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Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release by Foster, Daniel J., Wilson, Jermaine M., Remke, Daniel H., Mahmood, M. Suhaib, Uddin, M. Jashim, Wess, Jürgen, Patel, Sachin, Marnett, Lawrence J., Niswender, Colleen M., Jones, Carrie K., Xiang, Zixiu, Lindsley, Craig W., Rook, Jerri M., Conn, P. Jeffrey

“…Muscarinic receptors represent a promising therapeutic target for schizophrenia, but the mechanisms underlying the antipsychotic efficacy of muscarinic…”
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Cannabinoid type-2 receptors: An emerging target for regulating schizophrenia-relevant brain circuits by Ferranti, Anthony S., Foster, Daniel J.

“…Although the cannabinoid type-2 receptor (CB2) is highly expressed in the immune system, emerging evidence points to CB2 playing a key role in regulating…”
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Indirect detector for ultra‐high‐speed X‐ray micro‐imaging with increased sensitivity to near‐ultraviolet scintillator emission by Lukić, Bratislav, Rack, Alexander, Helfen, Lukas, Foster, Daniel J., Ershov, Alexey, Welss, Richard, François, Stéphane, Rochet, Xavier

“…Ultra‐high‐speed synchrotron‐based hard X‐ray (i.e. above 10 keV) imaging is gaining a growing interest in a number of scientific domains for tracking…”
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Genome-wide CRISPR interference screen identifies long non-coding RNA loci required for differentiation and pluripotency by Haswell, Jeffrey R, Mattioli, Kaia, Gerhardinger, Chiara, Maass, Philipp G, Foster, Daniel J, Peinado, Paola, Wang, Xiaofeng, Medina, Pedro P, Rinn, John L, Slack, Frank J

“…Although many long non-coding RNAs (lncRNAs) exhibit lineage-specific expression, the vast majority remain functionally uncharacterized in the context of…”
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Bile diversion, a bariatric surgery, and bile acid signaling reduce central cocaine reward by Reddy, India A, Smith, Nicholas K, Erreger, Kevin, Ghose, Dipanwita, Saunders, Christine, Foster, Daniel J, Turner, Brandon, Poe, Amanda, Albaugh, Vance L, McGuinness, Owen, Hackett, Troy A, Grueter, Brad A, Abumrad, Naji N, Flynn, Charles Robb, Galli, Aurelio

“…The gut-to-brain axis exhibits significant control over motivated behavior. However, mechanisms supporting this communication are poorly understood. We reveal…”
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A retrospective observational study of patient analgesia outcomes when regional anaesthesia procedures are performed by consultants versus supervised trainees by Chin, Adrian, Foster, Daniel J, Pelecanos, Anita M, Eley, Victoria A

“…At teaching hospitals, consultants must provide effective supervision, including appropriate selection of teaching cases, such that the outcomes achieved by…”
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Allosteric activation of M₄ muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice by Pancani, Tristano, Foster, Daniel J., Moehle, Mark S., Bichell, Terry Jo, Bradley, Emma, Bridges, Thomas M., Klar, Rebecca, Poslusney, Mike, Rook, Jerri M., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Wood, Michael R., Bowman, Aaron B., Lindsley, Craig W., Xiang, Zixiu, Conn, P. Jeffrey

“…Mutations that lead to Huntington’s disease (HD) result in increased transmission at glutamatergic corticostriatal synapses at early presymptomatic stages that…”
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lin-4 and the NRDE pathway are required to activate a transgenic lin-4 reporter but not the endogenous lin-4 locus in C. elegans by Jiao, Alan L, Foster, Daniel J, Dixon, Julia, Slack, Frank J

“…As the founding member of the microRNA (miRNA) gene family, insights into lin-4 regulation and function have laid a conceptual foundation for countless…”
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Muscarinic receptors: from clinic to bench to clinic by Foster, Daniel J.

“…Efforts to target muscarinic acetylcholine receptors in the brain have been hampered by dose-limiting side effects. In a tour de force of team science, Brown…”
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Receptor regulation of osmolyte homeostasis in neural cells by Fisher, Stephen K., Heacock, Anne M., Keep, Richard F., Foster, Daniel J.

“…The capacity of cells to correct their volume in response to hyposmotic stress via the efflux of inorganic and organic osmolytes is well documented. However,…”
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Targeting muscarinic receptors to treat schizophrenia by Foster, Daniel J., Bryant, Zoey K., Conn, P. Jeffrey

“…Schizophrenia is a severe neuropsychiatric disorder characterized by a diverse range of symptoms that can have profound impacts on the lives of patients…”
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Targeting the Actions of Muscarinic Receptors on Dopamine Systems: New Strategies for Treating Neuropsychiatric Disorders by Nunes, Eric J, Addy, Nii A, Conn, P. Jeffrey, Foster, Daniel J

“…Cholinergic regulation of dopamine (DA) signaling has significant implications for numerous disorders, including schizophrenia, substance use disorders, and…”
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Activation of Metabotropic Glutamate Receptor 3 Modulates Thalamo-accumbal Transmission and Rescues Schizophrenia-Like Physiological and Behavioral Deficits by Dogra, Shalini, Aguayo, Caleb, Xiang, Zixiu, Putnam, Jason, Smith, Joshua, Johnston, Curran, Foster, Daniel J., Lindsley, Craig W., Niswender, Colleen M., Conn, P. Jeffrey

“…Polymorphisms in the gene encoding for metabotropic glutamate receptor 3 (mGlu3) are associated with an increased likelihood of schizophrenia diagnosis and can…”
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Discovery of Potent, Orally Bioavailable Sphingosine-1-Phosphate Transporter (Spns2) Inhibitors by Foster, Daniel J., Dunnavant, Kyle, Shrader, Christopher W., LoPresti, Marion, Seay, Sarah, Kharel, Yugesh, Brown, Anne M., Huang, Tao, Lynch, Kevin R., Santos, Webster L.

“…Targeting the S1P pathway has resulted in the development of S1P1 receptor modulators for the treatment of multiple sclerosis and ulcerative colitis. We…”
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Activity in LIP, But not V4, Matches Performance When Attention is Spread by Arcizet, Fabrice, Mirpour, Koorosh, Foster, Daniel J, Bisley, James W

“…Abstract The enhancement of neuronal responses in many visual areas while animals perform spatial attention tasks has widely been thought to be the neural…”
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Ventral Tegmental Area M5 Muscarinic Receptors Mediate Effort-Choice Responding and Nucleus Accumbens Dopamine in a Sex-Specific Manner by Nunes, Eric J, Kebede, Nardos, Haight, Joshua L, Foster, Daniel J, Lindsley, Craig W, Conn, P Jeffrey, Addy, Nii A

“…Optimization of effort-related choices is impaired in depressive disorders. Acetylcholine (ACh) and dopamine (DA) are linked to depressive disorders, and…”
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Examining the role of muscarinic M5 receptors in VTA cholinergic modulation of depressive-like and anxiety-related behaviors in rats by Nunes, Eric J., Rupprecht, Laura E., Foster, Daniel J., Lindsley, Craig W., Conn, P. Jeffrey, Addy, Nii A.

“…Acetylcholine is implicated in mood disorders including depression and anxiety. Increased cholinergic tone in humans and rodents produces pro-depressive and…”
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Activation of the mGlu1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M4 muscarinic receptor allosteric modulators by Yohn, Samantha E., Foster, Daniel J., Covey, Dan P., Moehle, Mark S., Galbraith, Jordan, Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Bubser, Michael, Blobaum, Anna L., Joffe, Max E., Cheer, Joseph F., Jones, Carrie K., Lindsley, Craig W., Conn, P. Jeffrey

“…Recent clinical and preclinical studies suggest that selective activators of the M 4 muscarinic acetylcholine receptor have potential as a novel treatment for…”
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mGlu1-mediated restoration of prefrontal cortex inhibitory signaling reverses social and cognitive deficits in an NMDA hypofunction model in mice by Luessen, Deborah J., Gallinger, Isabel M., Ferranti, Anthony S., Foster, Daniel J., Melancon, Bruce J., Lindsley, Craig W., Niswender, Colleen M., Conn, P. Jeffrey

“…Extensive evidence supports the hypothesis that deficits in inhibitory GABA transmission in the prefrontal cortex (PFC) may drive pathophysiological changes…”
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