Search Results - "Foss, Joseph"

An overview of the cannabinoid type 2 receptor system and its therapeutic potential by Bie, Bihua, Wu, Jiang, Foss, Joseph F, Naguib, Mohamed

“…This narrative review summarizes recent insights into the role of the cannabinoid type 2 (CB2) receptor as potential therapeutic target in neuropathic pain and…”
Get full text

Activation of mGluR1 Mediates C1q-Dependent Microglial Phagocytosis of Glutamatergic Synapses in Alzheimer’s Rodent Models by Bie, Bihua, Wu, Jiang, Foss, Joseph F., Naguib, Mohamed

“…Microglia and complements appear to be involved in the synaptic and cognitive deficits in Alzheimer’s disease (AD), though the mechanisms remain elusive. In…”
Get full text

Activation of CB2 receptor system restores cognitive capacity and hippocampal Sox2 expression in a transgenic mouse model of Alzheimer's disease by Wu, Jiang, Hocevar, Mark, Foss, Joseph F., Bie, Bihua, Naguib, Mohamed

“…Alzheimer's disease (AD) is a neurodegenerative disorder characterized by neuroinflammation, extensive deposits of amyloid-β aggregates, and loss of memory and…”
Get full text

Amyloid Fibril–Induced Astrocytic Glutamate Transporter Disruption Contributes to Complement C1q-Mediated Microglial Pruning of Glutamatergic Synapses by Wu, Jiang, Bie, Bihua, Foss, Joseph F., Naguib, Mohamed

“…The complement C1q plays a critical role in microglial phagocytosis of glutamatergic synapses and in the pathogenesis of neuroinflammation in Alzheimer’s…”
Get full text

Amyloid fibrils induce dysfunction of hippocampal glutamatergic silent synapses by Bie, Bihua, Wu, Jiang, Foss, Joseph F., Naguib, Mohamed

“…Silent glutamatergic synapses lacking functional AMPA (α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazoleproprionate) receptors exist in several brain regions including…”
Get full text

Medical Use of Marijuana: Truth in Evidence by Naguib, Mohamed, Foss, Joseph F.

Get full text

Activation of cannabinoid receptor 2 attenuates mechanical allodynia and neuroinflammatory responses in a chronic post-ischemic pain model of complex regional pain syndrome type I in rats by Xu, Jijun, Tang, Yuying, Xie, Mian, Bie, Bihua, Wu, Jiang, Yang, Hui, Foss, Joseph F., Yang, Bin, Rosenquist, Richard W., Naguib, Mohamed

“…Complex regional pain syndrome type 1 (CRPS‐I) remains one of the most clinically challenging neuropathic pain syndromes and its mechanism has not been fully…”
Get full text

A Multimodal Approach to Discover Biomarkers for Taxane-Induced Peripheral Neuropathy (TIPN): A Study Protocol by Sharma, Anukriti, Johnson, Ken B., Bie, Bihua, Rhoades, Emily E., Sen, Alper, Kida, Yuri, Hockings, Jennifer, Gatta, Alycia, Davenport, Jacqueline, Arcangelini, Connie, Ritzu, Jennifer, DeVecchio, Jennifer, Hughen, Ron, Wei, Mei, Thomas Budd, G., Lynn Henry, N., Eng, Charis, Foss, Joseph, Rotroff, Daniel M.

“…Introduction: Taxanes are a class of chemotherapeutics commonly used to treat various solid tumors, including breast and ovarian cancers. Taxane-induced…”
Get full text

Peripherally Acting Mu-Opioid Receptor Antagonists and Postoperative Ileus: Mechanisms of Action and Clinical Applicability by Viscusi, Eugene R., Gan, Tong J., Leslie, John B., Foss, Joseph F., Talon, Mark D., Du, Wei, Owens, Gay

“…Postoperative ileus (POI), a transient cessation of coordinated bowel function after surgery, is an important health care problem. The etiology of POI is…”
Get full text

Genetic variations that influence paclitaxel pharmacokinetics and intracellular effects that may contribute to chemotherapy-induced neuropathy: A narrative review by Johnson, Ken B, Sharma, Anukriti, Henry, N Lynn, Wei, Mei, Bie, Bihua, Hershberger, Courtney E, Rhoades, Emily E, Sen, Alper, Johnson, Ryan E, Steenblik, Jacob, Hockings, Jennifer, Budd, G Thomas, Eng, Charis, Foss, Joseph, Rotroff, Daniel M

“…Taxanes, particularly paclitaxel and docetaxel, are chemotherapeutic agents commonly used to treat breast cancers. A frequent side effect is…”
Get full text

A Review of the Potential Role of Methylnaltrexone in Opioid Bowel Dysfunction by Foss, Joseph F

“…Opioids are widely used analgesics in patients with advanced cancer. However, their effectiveness for pain relief is often limited by the most frequently…”
Get full text

Effects of subcutaneous methylnaltrexone on morphine-induced peripherally mediated side effects: a double-blind randomized placebo-controlled trial by Yuan, Chun-Su, Wei, Gang, Foss, Joseph F, O'Connor, Michael, Karrison, Theodore, Osinski, Joachim

“…Methylnaltrexone, the first peripheral opioid receptor antagonist, has the potential to prevent or reverse opioid-induced peripherally mediated side effects…”
Get more information

Comparing methods of clinical measurement : Reporting standards for Bland and Altman analysis by MANTHA, S, ROIZEN, M. F, FLEISHER, L. A, THISTED, R, FOSS, J

“…In this era of medical technology assessment and evidence-based medicine, evaluating new methods to measure physiologic variables is facilitated by…”
Get full text

Methylnaltrexone for Reversal of Constipation Due to Chronic Methadone Use: A Randomized Controlled Trial by Yuan, Chun-Su, Foss, Joseph F, O'Connor, Michael, Osinski, Joachim, Karrison, Theodore, Moss, Jonathan, Roizen, Michael F

“…CONTEXT Constipation is the most common chronic adverse effect of opioid pain medications in patients who require long-term opioid administration, such as…”
Get full text

Are Peripheral Opioid Antagonists the Solution to Opioid Side Effects? by Bates, John J., Foss, Joseph F., Murphy, Damian B.

“…Opioid medication is the mainstay of therapy for severe acute and chronic pain. Unfortunately, the side effects of these medications can affect patient comfort…”
Get full text

Use of the CTrach Laryngeal Mask Airway in adult patients: a retrospective review of 126 cases by Maurtua, Marco A., MD, Fernando, Michael, MD, Finnegan, Patrick S., NREMT-B, Mehta, Behram, MS4, Wu, Jiang, MD, Foss, Joseph, MD, Perilla, Mauricio, MD, Zura, Andrew, MD, Doyle, D. John, MD, PhD

“…Abstract Study Objective To evaluate the effectiveness of the CTrach Laryngeal Mask Airway (LMA) when used electively. Design Retrospective analysis. Setting…”
Get full text

Development and use of methylnaltrexone, a peripherally acting opioid antagonist, to treat side effects related to opioid use by Yuan, Chun-Su, Foss, Joseph F., Williams, Wade A., Moss, Jonathan

“…Opioid medications are used extensively as potent analgesics for treating moderate to severe pain. Although opioids offer reliable pain relief, their use is…”
Get full text

A phase I single ascending dose safety study of NTRX‐07 in normal volunteers by Foss, Joseph, Naguib, Mohamed, Giordano, Tony

“…Background NTRX‐07 is a selective cannabinoid receptor type 2 (CB2) agonist that has been shown in animal models to be effective for the treatment of…”
Get full text

A phase I single ascending dose safety study of NTRX‐07 in normal volunteers: Human/Human trials: Inflammation by Foss, Joseph, Naguib, Mohamed, Giordano, Tony

“…Abstract Background NTRX‐07 is a selective cannabinoid receptor type 2 (CB 2 ) agonist that has been shown in animal models to be effective for the treatment…”
Get full text

Effects of Low-Dose Morphine on Gastric Emptying in Healthy Volunteers by Yuan, Chun-Su, Foss, Joseph F., O'Connor, Michael, Roizen, Michael F., Moss, Jonathan

“…Appropriate preoperative pain therapy for patients undergoing surgery may be withheld due to the fear that opioids will inhibit gastric emptying and increase…”
Get full text