Search Results - "Forty, Ellen"

The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis by Woodcock, Hannah V., Eley, Jessica D., Guillotin, Delphine, Platé, Manuela, Nanthakumar, Carmel B., Martufi, Matteo, Peace, Simon, Joberty, Gerard, Poeckel, Daniel, Good, Robert B., Taylor, Adam R., Zinn, Nico, Redding, Matthew, Forty, Ellen J., Hynds, Robert E., Swanton, Charles, Karsdal, Morten, Maher, Toby M., Fisher, Andrew, Bergamini, Giovanna, Marshall, Richard P., Blanchard, Andy D., Mercer, Paul F., Chambers, Rachel C.

“…Myofibroblasts are the key effector cells responsible for excessive extracellular matrix deposition in multiple fibrotic conditions, including idiopathic…”
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mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β 1 -induced collagen biosynthesis by Selvarajah, Brintha, Azuelos, Ilan, Platé, Manuela, Guillotin, Delphine, Forty, Ellen J, Contento, Greg, Woodcock, Hannah V, Redding, Matthew, Taylor, Adam, Brunori, Gino, Durrenberger, Pascal F, Ronzoni, Riccardo, Blanchard, Andy D, Mercer, Paul F, Anastasiou, Dimitrios, Chambers, Rachel C

“…The differentiation of fibroblasts into a transient population of highly activated, extracellular matrix (ECM)-producing myofibroblasts at sites of tissue…”
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The urotensin system is up-regulated in the pre-hypertensive spontaneously hypertensive rat by Forty, Ellen J, Ashton, Nick

“…Urotensin II (UII) concentrations are raised both in humans with hypertension and in spontaneously hypertensive rats (SHR). Since the urotensin system acts to…”
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Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis by John, Alison E., Graves, Rebecca H., Pun, K. Tao, Vitulli, Giovanni, Forty, Ellen J., Mercer, Paul F., Morrell, Josie L., Barrett, John W., Rogers, Rebecca F., Hafeji, Maryam, Bibby, Lloyd I., Gower, Elaine, Morrison, Valerie S., Man, Yim, Roper, James A., Luckett, Jeni C., Borthwick, Lee A., Barksby, Ben S., Burgoyne, Rachel A., Barnes, Rory, Le, Joelle, Flint, David J., Pyne, Susan, Habgood, Anthony, Organ, Louise A., Joseph, Chitra, Edwards-Pritchard, Rochelle C., Maher, Toby M., Fisher, Andrew J., Gudmann, Natasja Stæhr, Leeming, Diana J., Chambers, Rachel C., Lukey, Pauline T., Marshall, Richard P., Macdonald, Simon J. F., Jenkins, R. Gisli, Slack, Robert J.

“…The αvβ6 integrin plays a key role in the activation of transforming growth factor-β (TGFβ), a pro-fibrotic mediator that is pivotal to the development of…”
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Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation by SCOTTON, Chris J, HAYES, Brian, ALEXANDER, Robert, DATTA, Arnab, FORTY, Ellen J, MERCER, Paul F, BLANCHARD, Andy, CHAMBERS, Rachel C

“…Research into the pathogenesis underlying the development of idiopathic pulmonary fibrosis is hampered by a repertoire of animal models that fail to…”
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Author Correction: The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis by Woodcock, Hannah V., Eley, Jessica D., Guillotin, Delphine, Platé, Manuela, Nanthakumar, Carmel B., Martufi, Matteo, Peace, Simon, Joberty, Gerard, Poeckel, Daniel, Good, Robert B., Taylor, Adam R., Zinn, Nico, Redding, Matthew, Forty, Ellen J., Hynds, Robert E., Swanton, Charles, Karsdal, Morten, Maher, Toby M., Fisher, Andrew, Bergamini, Giovanna, Marshall, Richard P., Blanchard, Andy D., Mercer, Paul F., Chambers, Rachel C.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Suprafamilial relationships among Rodentia and the phylogenetic effect of removing fast-evolving nucleotides in mitochondrial, exon and intron fragments by Montgelard, Claudine, Forty, Ellen, Arnal, Véronique, Matthee, Conrad A

“…The number of rodent clades identified above the family level is contentious, and to date, no consensus has been reached on the basal evolutionary…”
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Ontogeny of the renal urotensin II system in the rat by Forty, Ellen J., Ashton, Nick

“…Urotensin II (UII), a peptide hormone which influences glomerular filtration rate and urine concentration, and its receptor, UT, are expressed in the adult rat…”
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Renal haemodynamic and tubular actions of urotensin II in the rat by Abdel-Razik, Alaa E S, Forty, Ellen J, Balment, Richard J, Ashton, Nick

“…Urotensin II (UTS) is a potent vasoactive peptide that was originally identified in teleost fish. Mammalian orthologues of UTS and its receptor (UTSR) have…”
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Endogenous renal urotensin II and its role in sodium and water handling in the young rat by Forty, Ellen, Ashton, Nicholas

“…Urotensin II (UII) is a vasoactive peptide which has been implicated in human cardiovascular and renal disease. We have demonstrated a role for the urotensin…”
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LSC - 2017 - Targeting glucose metabolism in experimental lung injury and fibrosis by Ellen Forty, Ilan Azuelos, Tammy Kalber, Gendron, Thibault, May Zaw-Thin, Giovanni Vitulli, John Barrett, Dimitrios Anastasiou, Paul Mercer, Andy Blanchard, Rachel Chambers

“…Introduction:Akin to many cancers, enhanced18F-FDG-PET signal has been associated with fibrotic lesions in pulmonary fibrosis. In tumors, elevated glucose…”
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