Search Results - "Fortunak, Joseph M"

Cheminfomatic-based Drug Discovery of Human Tyrosine Kinase Inhibitors by Reid, Terry-Elinor, Fortunak, Joseph M, Wutoh, Anthony, Simon Wang, Xiang

“…Receptor Tyrosine Kinases (RTKs) are essential components for regulating cell-cell signaling and communication events in cell growth, proliferation,…”
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A survey of the syntheses of active pharmaceutical ingredients for antiretroviral drug combinations critical to access in emerging nations by Pinheiro, Eloan dos Santos, Antunes, Octavio Augusto Ceva, Fortunak, Joseph M.D.

“…It has been roughly 25 years since the threat posed by human immunodeficiency virus type 1 (HIV-1) became widely known. The cumulative death toll from HIV/AIDS…”
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An Efficient Chiral Moderator Prepared from Inexpensive (+)-3-Carene:  Synthesis of the HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor DPC 963 by Kauffman, Goss S, Harris, Gregory D, Dorow, Roberta L, Stone, Benjamin R. P, Parsons, Rodney L, Pesti, Jaan A, Magnus, Nicholas A, Fortunak, Joseph M, Confalone, Pat N, Nugent, William A

“…The β-amino alcohol 4β-morpholinocaran-3α-ol is prepared by addition of morpholine to α-3,4-epoxycarane utilizing anhydrous magnesium bromide as Lewis acid…”
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Structural and Rate Studies of the 1,2-Additions of Lithium Phenylacetylide to Lithiated Quinazolinones:  Influence of Mixed Aggregates on the Reaction Mechanism by Briggs, Timothy F, Winemiller, Mark D, Collum, David B, Parsons, Rodney L, Davulcu, Akin H, Harris, Gregory D, Fortunak, Joseph M, Confalone, Pat N

“…The 1,2-addition of lithium phenylacetylide (PhCCLi) to quinazolinones was investigated using a combination of structural and rate studies. 6Li, 13C, and 19F…”
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A Practical Preparation of Terminal Alkynes from Aldehydes by Wang, Zhe, Campagna, Silvio, Yang, Kaihong, Xu, Guoyou, Pierce, Michael E, Fortunak, Joseph. M, Confalone, Pat. N

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Eco-Friendly Synthesis of Fine Chemicals by Fortunak, Joseph M

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7-Chloro-4-(piperazin-1-yl)quinoline by Kulkarni, Amol A, King, Christopher L, Fortunak, Joseph M D, Butcher, Ray J

“…There are two mol-ecules in the asymmetric unit (Z' = 2) of the title compound, C(13)H(14)ClN(3), Each mol-ecule is linked by N-H⋯N hydrogen bonds to another…”
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In Situ Recycling of Chiral Ligand and Surplus Nucleophile for a Noncatalytic Reaction:  Amplification of Process Throughput in the Asymmetric Addition Step of Efavirenz (DMP 266) by Choudhury, Anusuya, Moore, James R, Pierce, Michael E, Fortunak, Joseph M, Valvis, Ioannis, Confalone, Pat N

“…The synthesis of efavirenz (DMP 266) involves a highly enantioselective asymmetric reaction of ketone 2a with lithium cyclopropylacetylide 3a in the presence…”
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A new and practical synthesis of vinyl dichlorides via a non-Wittig-type approach by Wang, Zhe, Campagna, Silvio, Xu, Guoyou, Pierce, Michael E, Fortunak, Joseph M, Confalone, Pat N

“…A practical approach for the conversion of aldehydes to vinyl dichlorides has been developed. These are three-step, one-pot reactions involving the formation…”
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Competition, Selectivity and Efficacy of Analogs of A-84543 for Nicotinic Acetylcholine Receptors with Repositioning of Pyridine Nitrogen by Ogunjirin, Adebowale E., Fortunak, Joseph M., Brown, LaVerne L., Xiao, Yingxian, Dávila-García, Martha I.

“…Nicotinic acetylcholine receptors (nAChRs) play a crucial role in a number of clinically relevant mental and neurological pathways, as well as autonomic and…”
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Current and future impact of green chemistry on the pharmaceutical industry by Fortunak, Joseph M

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Active pharmaceutical ingredients for antiretroviral treatment in low- and middle-income countries: a survey by Fortunak, Joseph M, de Souza, Rodrigo O M A, Kulkarni, Amol A, King, Christopher L, Ellison, Tiffany, Miranda, Leandro S M

“…Active pharmaceutical ingredients (APIs) are the molecular entities that exert the therapeutic effects of medicines. This article provides an overview of the…”
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An Alternative Approach for the Conversion of Aldehydes to Terminal Alkynes by Wang, Zhe, Yin, Jianguo, Campagna, Silvio, Pesti, Jaan A, Fortunak, Joseph M

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Stereoselective Process for a CCR3 Antagonist by Yue, Tai-Yuen, McLeod, Douglas D, Albertson, Kevin B, Beck, Steven R, Deerberg, Joerg, Fortunak, Joseph M, Nugent, William A, Radesca, Lilian A, Tang, Liya, Xiang, Cathie Dong

“…A convergent, multikilogram, stereoselective synthesis of 1 is described. A key fragment, (S)-3-(4-fluorobenzyl)piperidine (2) was synthesized from…”
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4,7-Dichloroquinoline by Kulkarni, Amol A., King, Christopher, Butcher, Ray J., Fortunak, Joseph M. D.

“…The two molecules in the asymmetric unit of the title compound, C9H5Cl2N, are both essentially planar (r.m.s. deviations for all non-H atoms = 0.014 and…”
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A New Regioselective Synthesis of 1,2,5-Trisubstituted 1H-Imidazoles and Its Application to the Development of Eprosartan by Shilcrat, Susan C, Mokhallalati, Mohamed K, Fortunak, Joseph M. D, Pridgen, Lendon N

“…A new method is presented for the preparation of 1,2-disubstitued-1H-imidazole-5-carboxaldehydes by the reaction of N-monosubstituted amidines with…”
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NMR Spectroscopic Investigations of Mixed Aggregates Underlying Highly Enantioselective 1,2-Additions of Lithium Cyclopropylacetylide to Quinazolinones by Parsons, Rodney L, Fortunak, Joseph M, Dorow, Roberta L, Harris, Gregory D, Kauffman, Goss S, Nugent, William A, Winemiller, Mark D, Briggs, Timothy F, Xiang, Bosong, Collum, David B

“…The solution structures of mixed aggregates derived from lithium alkoxides and lithium acetylides were investigated as part of a program to develop practical…”
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An Efficient, Green Chemical Synthesis of the Malaria Drug, Piperaquine by Fortunak, Joseph MD, Byrn, Stephen R, Dyson, Brandon, Ekeocha, Zita, Ellison, Tiffany, King, Christopher L, Kulkarni, Amol A, Lee, Mindy, Conrad, Chelsea, Thompson, Keeshaloy

“…Purpose: To provide a robust, efficient synthesis of the malaria drug piperaquine for potential use in resource-poor settings. Methods: We used in-process…”
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The isolation and identification of a toxic impurity in XP315 drug substance by Sigvardson, Kenneth W, Adams, Stephen P, Barnes, T.Bradford, Blom, Karl F, Fortunak, Joseph M, Haas, Michael J, Reilly, Kathleen L, Repta, Arnold J, Nemeth, Gregory A

“…In early safety assessment studies with the experimental anti-neoplastic drug XP315, a toxic reaction was observed in dogs immediately after intravenous (iv)…”
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Efficient Pyridinylmethyl Functionalization:  Synthesis of 10,10-Bis[(2-fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone (DMP 543), an Acetylcholine Release Enhancing Agent by Pesti, Jaan A, Huhn, George F, Yin, Jianguo, Xing, Yide, Fortunak, Joseph M, Earl, Richard A

“…2-Fluoro-4-methylpyridine (3) is efficiently functionalized by chlorination, hydrolysis and methanesulfonylation into the novel alkylating agent 7. This…”
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