Search Results - "Fortuna, Patrick R. J."

Advances in reprogramming to pluripotency by Alateeq, Suad, Fortuna, Patrick R J, Wolvetang, Ernst

“…Pluripotent stem cells (PSCs) derived from somatic cells represent a powerful experimental tool for investigating the molecular mechanisms underlying the…”
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Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis by Rashidieh, Behnam, Shohayeb, Belal, Bain, Amanda Louise, Fortuna, Patrick R. J, Sinha, Debottam, Burgess, Andrew, Mills, Richard, Adams, Rachael C, Lopez, J. Alejandro, Blumbergs, Peter, Finnie, John, Kalimutho, Murugan, Piper, Michael, Hudson, James Edward, Ng, Dominic C. H, Khanna, Kum Kum

“…Homozygous nonsense mutations in CEP55 are associated with several congenital malformations that lead to perinatal lethality suggesting that it plays a…”
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Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression by Pierson Smela, Merrick D, Kramme, Christian C, Fortuna, Patrick R J, Adams, Jessica L, Su, Rui, Dong, Edward, Kobayashi, Mutsumi, Brixi, Garyk, Kavirayuni, Venkata Srikar, Tysinger, Emma, Kohman, Richie E, Shioda, Toshi, Chatterjee, Pranam, Church, George M

“…An in vitro model of human ovarian follicles would greatly benefit the study of female reproduction. Ovarian development requires the combination of germ cells…”
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Correction: Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression by Pierson Smela, Merrick D, Kramme, Christian C, Fortuna, Patrick R J, Adams, Jessica L, Su, Alina Rui, Dong, Edward, Kobayashi, Mutsumi, Brixi, Garyk, Kavirayuni, Venkata Srikar, Tysinger, Emma, Kohman, Richie E, Shioda, Toshi, Chatterjee, Pranam, Church, George M

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Progress and limitations in engineering cellular adhesion for research and therapeutics by Chao, George, Zukin, Stefan, Fortuna, Patrick R.J., Boettner, Benjamin, Church, George M.

“…The ability to direct cell–cell interactions through engineered cell adhesion molecules (CAMs) represents an emerging frontier in studying cell biology and in…”
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Human-induced pluripotent stem cell-derived ovarian support cell co-culture improves oocyte maturation in vitro after abbreviated gonadotropin stimulation by Piechota, Sabrina, Marchante, Maria, Giovannini, Alexa, Paulsen, Bruna, Potts, Kathryn S, Rockwell, Graham, Aschenberger, Caroline, Noblett, Alexander D, Figueroa, Alexandra B, Sanchez, Marta, Barrachina, Ferran, Wiemer, Klaus, Guzman, Luis, Belchin, Pedro, Pierson Smela, Merrick, Fortuna, Patrick R J, Chatterjee, Pranam, Tran, Nam D, Kelk, Dawn A, Forti, Marcy, Marcinyshyn, Shelby, Smith, Trozalla, McCulloh, David H, Fernandez-Gonzalez, Marta-Julia, Abittan, Baruch, Ortiz, Silvia, Klein, Joshua U, Klatsky, Peter, Ordonez-Perez, Daniel, Kramme, Christian C

“…Abstract STUDY QUESTION Can in vitro maturation (IVM) and developmental competence of human oocytes be improved by co-culture with ovarian support cells (OSCs)…”
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Vascular cells improve functionality of human cardiac organoids by Voges, Holly K., Foster, Simon R., Reynolds, Liam, Parker, Benjamin L., Devilée, Lynn, Quaife-Ryan, Gregory A., Fortuna, Patrick R.J., Mathieson, Ellen, Fitzsimmons, Rebecca, Lor, Mary, Batho, Christopher, Reid, Janice, Pocock, Mark, Friedman, Clayton E., Mizikovsky, Dalia, Francois, Mathias, Palpant, Nathan J., Needham, Elise J., Peralta, Marina, Monte-Nieto, Gonzalo del, Jones, Lynelle K., Smyth, Ian M., Mehdiabadi, Neda R., Bolk, Francesca, Janbandhu, Vaibhao, Yao, Ernestene, Harvey, Richard P., Chong, James J.H., Elliott, David A., Stanley, Edouard G., Wiszniak, Sophie, Schwarz, Quenten, James, David E., Mills, Richard J., Porrello, Enzo R., Hudson, James E.

“…Crosstalk between cardiac cells is critical for heart performance. Here we show that vascular cells within human cardiac organoids (hCOs) enhance their…”
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The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states by Barry, Guy, Briggs, James A., Hwang, Do Won, Nayler, Sam P., Fortuna, Patrick R. J., Jonkhout, Nicky, Dachet, Fabien, Maag, Jesper L. V., Mestdagh, Pieter, Singh, Erin M., Avesson, Lotta, Kaczorowski, Dominik C., Ozturk, Ezgi, Jones, Nigel C., Vetter, Irina, Arriola-Martinez, Luis, Hu, Jianfei, Franco, Gloria R., Warn, Victoria M., Gong, Andrew, Dinger, Marcel E., Rigo, Frank, Lipovich, Leonard, Morris, Margaret J., O’Brien, Terence J., Lee, Dong Soo, Loeb, Jeffrey A., Blackshaw, Seth, Mattick, John S., Wolvetang, Ernst J.

“…Despite their abundance, the molecular functions of long non-coding RNAs in mammalian nervous systems remain poorly understood. Here we show that the long…”
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Dynamic Methylation of an L1 Transduction Family during Reprogramming and Neurodifferentiation by Salvador-Palomeque, Carmen, Sanchez-Luque, Francisco J., Fortuna, Patrick R. J., Ewing, Adam D., Wolvetang, Ernst J., Richardson, Sandra R., Faulkner, Geoffrey J.

“…The retrotransposon LINE-1 (L1) is a significant source of endogenous mutagenesis in humans. In each individual genome, a few retrotransposition-competent L1s…”
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Rescue in vitro maturation using ovarian support cells of human oocytes from conventional stimulation cycles yields oocytes with improved nuclear maturation and transcriptomic resemblance to in vivo matured oocytes by Paulsen, Bruna, Piechota, Sabrina, Barrachina, Ferran, Giovannini, Alexa, Kats, Simone, Potts, Kathryn S., Rockwell, Graham, Marchante, Maria, Estevez, Samantha L., Noblett, Alexander D., Figueroa, Alexandra B., Aschenberger, Caroline, Kelk, Dawn A., Forti, Marcy, Marcinyshyn, Shelby, Wiemer, Klaus, Sanchez, Marta, Belchin, Pedro, Lee, Joseph A., Buyuk, Erkan, Slifkin, Rick E., Smela, Merrick Pierson, Fortuna, Patrick R. J., Chatterjee, Pranam, McCulloh, David H., Copperman, Alan B., Ordonez-Perez, Daniel, Klein, Joshua U., Kramme, Christian C.

“…Purpose Determine if the gene expression profiles of ovarian support cells (OSCs) and cumulus-free oocytes are bidirectionally influenced by co-culture during…”
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Generation and characterization of leukemia inhibitory factor-dependent equine induced pluripotent stem cells from adult dermal fibroblasts by Whitworth, Deanne J, Ovchinnikov, Dmitry A, Sun, Jane, Fortuna, Patrick R J, Wolvetang, Ernst J

“…In this study we have reprogrammed dermal fibroblasts from an adult female horse into equine induced pluripotent stem cells (equiPSCs). These equiPSCs are…”
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Transgenic human ES and iPS reporter cell lines for identification and selection of pluripotent stem cells in vitro by Ovchinnikov, Dmitry A., Titmarsh, Drew M., Fortuna, Patrick R.J., Hidalgo, Alejandro, Alharbi, Samah, Whitworth, Deanne J., Cooper-White, Justin J., Wolvetang, Ernst J.

“…Optimization of pluripotent stem cell expansion and differentiation is facilitated by biological tools that permit non-invasive and dynamic monitoring of…”
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BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection by Mills, Richard J., Humphrey, Sean J., Fortuna, Patrick R.J., Lor, Mary, Foster, Simon R., Quaife-Ryan, Gregory A., Johnston, Rebecca L., Dumenil, Troy, Bishop, Cameron, Rudraraju, Rajeev, Rawle, Daniel J., Le, Thuy, Zhao, Wei, Lee, Leo, Mackenzie-Kludas, Charley, Mehdiabadi, Neda R., Halliday, Christopher, Gilham, Dean, Fu, Li, Nicholls, Stephen J., Johansson, Jan, Sweeney, Michael, Wong, Norman C.W., Kulikowski, Ewelina, Sokolowski, Kamil A., Tse, Brian W.C., Devilée, Lynn, Voges, Holly K., Reynolds, Liam T., Krumeich, Sophie, Mathieson, Ellen, Abu-Bonsrah, Dad, Karavendzas, Kathy, Griffen, Brendan, Titmarsh, Drew, Elliott, David A., McMahon, James, Suhrbier, Andreas, Subbarao, Kanta, Porrello, Enzo R., Smyth, Mark J., Engwerda, Christian R., MacDonald, Kelli P.A., Bald, Tobias, James, David E., Hudson, James E.

“…Cardiac injury and dysfunction occur in COVID-19 patients and increase the risk of mortality. Causes are ill defined but could be through direct cardiac…”
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Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis by Behnam Rashidieh, Belal Shohayeb, Amanda Louise Bain, Patrick R J Fortuna, Debottam Sinha, Andrew Burgess, Richard Mills, Rachael C Adams, J Alejandro Lopez, Peter Blumbergs, John Finnie, Murugan Kalimutho, Michael Piper, James Edward Hudson, Dominic C H Ng, Kum Kum Khanna

“…Homozygous nonsense mutations in CEP55 are associated with several congenital malformations that lead to perinatal lethality suggesting that it plays a…”
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